A 65-year-old female smoker was admitted due to haemoptysis and a pulmonary infiltrate in the right lower lung lobe. Tumour was suspected, but there was also a history of 2 years spent in Arizona, known to be endemic for the dimorphic fungus Coccidioides immitis. IgG antibodies and airway culture for C. immitis were negative, and surgery was performed for suspected lung cancer. No malignancy was detected at histopathological investigation, but typical coccidioidal spherulae were observed by silver stain. Coccidioidoma may be a differential diagnosis to malignant tumour in individuals visiting endemic areas.

Keywords:
Coccidioidomycosis, Coccidioidoma, Lung cancer
1.
Rippon JW: Coccidioidomycosis; in Rippon JW (ed): Medical Mycology, ed 3. Philadelphia, Saunders, 1988, pp 389–427.
2.
Coccidioidomycosis in travelers returning from Mexico – Pennsylvania, 2000. MMWR Morb Mortal Wkly Rep 2000;49:1004–1006.
3.
Salfelder K: Atlas of Fungal Histopathology. Dordrecht, Kluwer Academic Publishers, 1990.
4.
Cox AJ, Smith CE: Arrested pulmonary coccidioidomycosis granuloma. Arch Pathol 1939:27:717–734.
5.
Rosenstein NE, Emery KW, Werner SB, Kao A, Johnson R, et al: Risk factors for severe pulmonary and disseminated coccidioidomycosis: Kern County, California, 1995–1996. Clin Infect Dis 2001;32:708–715.
6.
Arsura EL, Kilgore WB: Miliary coccidioidomycosis in the immunocompetent. Chest 2000;117:404–409.
7.
Polesky A, Kirsch CM, Snyder LS, LoBue P, Kagawa FT, et al: Airway coccidioidomycosis – Report of cases and review. Clin Infect Dis 1999;28:1273–1280.
8.
Galgiani JN, Ampel NM, Catanzaro A, Johnson RH, Stevens DA, Williams PL: Practice guidelines for the treatment of coccidioidomycosis. Clin Infect Dis 2000;30:658–661.
9.
Li RK, Ciblak MA, Nordoff N, Pasarell L, Warnock DW, McGinnis MR: In vitro activities of voriconazole, itraconazole, and amphotericin B against Blastomyces dermatitidis, Coccidioides immitis, and Histoplasma capsulatum. Antimicrob Agents Chemother 2000;44:1734–1736.
© 2003 S. Karger AG, Basel
2004
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