A few reports have suggested the possible association between lung cancer and bullous disease. We report a surgical case of lung adenocarcinoma located in close proximity to pulmonary bullae. A 48-year-old nonsmoker, asymptomatic male was found to have a pulmonary tumor mass and giant bulla in the right lung. Thoracotomy identified a tumor arising from a firm, scarred and contracted area close to the bulla wall. Based on this report and review of other cases in the literature, we emphasize the need for physicians to be aware of the potential development of lung cancer in patients with pulmonary bulla.

Keywords:
Lung cancer, Pulmonary bulla
1.
Goldstein MJ, Snider GL, Liberson M, Poske RM: Bronchogenic carcinoma and giant bullous disease. Am Rev Respir Dis 1968;97:1062–1070.
2.
Svennevig JL, Bugge-Asperheim B, Boye NP: Carcinoma arising in a lung cyst. Scand J Thor Cardiovasc Surg 1979;13:153–155.
3.
Ayers JG, Pitcher DW, Rees PJ: Pneumothorax associated with primary carcinoma. Br J Dis Chest 1980;74:180–182.
4.
Aronberg DJ, Sagel SS, LeFrak S, Kuhn C, Susman H: Lung carcinoma associated with bullous lung disease in young men. AJR 1980;134:249–252.
5.
Korol E: The correlation of carcinoma and congenital cystic emphysema of the lungs: Report of ten cases. Dis Chest 1953;23:403–411.
6.
Ettman EK: Bullous disease of the lung and bronchogenic carcinoma. South Med J 1968;61:743–747.
7.
Scannel JG: ‘Bleb’ carcinoma of the lung. J Thorac Cardiovasc Surg 1980;80:904–908.
8.
Watts MA, Klayton RJ, Munzel TL: Bullous emphysema and carcinoma of the lung: Case report. Mil Med 1982;147:320–323.
9.
Sheffield EA, Addis BJ, Corrin B, McCabe MM: Epithelial hyperplasia and malignant change in congenital lung cysts. J Clin Pathol 1987;40:612–614.
10.
Allan BT, Day DL, Dehner LP: Primary pulmonary rhabdomyosarcoma of the lung in children: Report of two cases presenting with spontaneous pneumothorax. Cancer 1987;59:1005–1011.
11.
Konwaler BE, Reingold IM: Carcinoma arising in bronchiectatic cavities. Cancer 1952;5:525–529.
12.
Wallace RJJ, Cohen A, Awe RJ, Greenberg D, Hadlock F, Park SK: Carcinomatous lung abscess: Diagnosis by bronchoscopy and cytopathology. JAMA 1979;242:521–522.
13.
Yeung K-Y, Bonnet JD: Bronchogenic carcinoma presenting as spontaneous pneumothorax: Case reports with review of literature. Cancer 1977;39:2286–2289.
14.
Stoloff IL, Kanofsky P, Magilner L: The risk of lung cancer in males with bullous disease of the lung. Arch Environ Health 1971;22:163–167.
15.
Womack NA, Graham EA: Epithelial metaplasia in congenital cystic disease of the lung: Its possible relation to carcinoma of the bronchus. Am J Pathol 1941;17:645–654.
16.
Yokoo H, Suckow EE: Peripheral lung cancers arising in scars. Cancer 1961;14:1205–1215.
17.
Freant LJ, Joseph WL, Adkins PC: Scar carcinoma of the lung, fact or fantasy. Ann Thorac Surg 1974;17:531–537.
18.
Venuta F, Rendina EA, Pescarmona EO, De Giacomo T, Vizza D, Flaishman I, Ricci C: Occult lung cancer in patients with bullous emphysema. Thorax 1997;52:289–290.
19.
Zulueta JJ, Bloom SM, Rozansky MI, White AC: Lung cancer in patients with bullous disease. Am J Respir Crit Care Med 1996;154:519–522.
20.
Shirakusa T, Shigematsu N, Koga T, Yamagata Y: Giant cell carcinoma arising in a pulmonary bulla. Scand J Thorac Cardiovasc Surg 1980;14:307–309.
21.
Koike R, Sasaki M, Kuroda K: Lung cancer coexisting with bullae (in Japanese). Jpn J Surg 1989;19:459–461.
22.
Matsuzoe D, Iwasaki A, Yoneda S, Yoshinaga Y, Kawahara K, Shirakusa T: Lung cancer with rare invasion arising from bulla wall: A case report (in Japanese). Jpn J Surg 1995;35:597–601.
23.
Kanzaki M, Onuki T, Shioiri M, Sato K, Nishiuchi M, Tatebayashi T, Sasano S, Kaneyasu H, Murasugi M,Kei J, Nitta S: A case report of undifferentiated lung cancer difficult in diagnosis by hemoptysis (in Japanese). Jpn J Thorac Surg 1996;11:40–44.
24.
Matsuki H, Kaneko Y, Furuse F, Kurita Y: Primary lung cancer and emphysematous bulla presenting pneumothorax as an initial manifestation (in Japanese). Jpn J Thorac Dis 1996;55:108–111.
25.
Toyoda F, Ishihara Y, Kageyama Y, Kobayashi T, Suzuki K, Harada Y: Small intestinal metastasis from lung cancer with emphysematous bullae (in Japanese). Jpn J Thorac Dis 1996;55:477–481.
© 1999 S. Karger AG, Basel
1999
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