Two methods for the efficacy evaluation of the respiratory tract clearance by cough, measuring the time of expectoration (Texp) of sputum mixed with hem-containing indicators after their inhalation were used in patients with bronchial obstruction. In the first method, the patients studied inhaled their own hemoglobin (Hb) and in the second one they inhaled a finely pulverized powder of hem-containing substances which were obtained from donor erythrocyte mass. 195 subjects were examined: 44 with intrinsic bronchial asthma (BA), 71 with obstructive bronchitis (OB) and 22 with purulent obstructive bronchitis (POB). Patients expectorating not less than 30 ml/day of sputum were selected. The control group consisted of 18 patients with non-obstructive bronchitis (NOB) and 40 healthy volunteers, nonsmokers. The sputum for analysis after the inhalation of the indicator in healthy persons was collected during coughing stimulated by inhaling a hypertonic solution (15% NaCl + 1% NaHCO3). It was found that Texp depends on the form of illness (means ± SEM): (1) with Hb technique, BA: 41.5 ± 3.4 h; OB: 59.3 ± 5.7 h and POB: 128.8 ± 15.3 h and (2) with the powdered indicator technique, BA: 53.4 ± 7.6 h; OB: 68.8 ± 6.6 h and POB: 101.1 ± 11.8 h. Control group: in patients with NOB, Texp measured with the Hb technique was 31.4 ± 4.3 h and with the powdered indicator 30.0 ± 10.3 h. In healthy volunteers, the presence of hem-containing substances in sputum after 36 h was not found. Correlation analysis of our data revealed the presence of a direct relationship between the pulmonary function impairment and the value of Texp only in the group of patients suffering from OB. A comparison of the efficacy of peroral and inhalation expectorants as shown by their influence on initial values of Texp was carried out. Expectoration efficacy amounted to (mean ± SEM): (1) peroral drugs: ambroxol 41.2 ± 5.1%, bromhexine 37.9 ± 8.6%, S-carboxymethylcysteine 30.4 ± 7.6%, and (2) inhalation drugs: n-acetylcys-teine 55.3 ± 5.3%, 2% solution of sodium bicarbonate 58.4 ± 3.8% and sodium bicarbonate in a dry aerosol form 52.5 ± 9.7%. The choice of the drug and the route of administration (peroral or inhalation) are determined by the degree of expectoration disturbances: first degree (Texp 36–48 h) can be compensated by peroral drugs; second degree (Texp 54–66 h) by inhalation drugs, and third degree (Texp 72 h and more) are decompensated and require the use of active bronchial toilet methods, such as bronchoscopy, or an increased number of daily drug inhalations

This content is only available via PDF.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.