A study of the platelet count in rats exposed to normobaric hypoxia for 4 weeks revealed that hypoxia alone, without any change in barometric pressure, considerably reduced the number of thrombocytes. In order to elucidate the mechanism of hypoxic thrombocytopenia, the survival and recovery of 51Cr-labelled platelets were tested. The survival and recovery of platelets from hypoxic rats injected into normoxic recipients were normal. However, when 51Cr-labelled platelets from normoxic rats were injected into a hypoxic recipient, the survival was found to be normal but the recovery of those platelets was lower than in the normal rat. This finding suggests that the reduction of platelet counts in normobaric hypoxia may be due to the platelets’ partial sequestration.

Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.