The histamine inhalation provocation test (HIP) was followed during 5 weeks. This test was performed four (1 patient) or five times under standardized conditions in a group of 21 asthmatic patients. The HIP was performed with increasing concentrations of histamine phosphate produced by a ‘Wiesbadener Doppelinhalator’. The HIP was called positive if there was a drop of 15% of the initial FEV1. 12 out of 21 patients (57%) showed a sufficient reproducibility. For the whole group of patients there hardly was a variability of the mean absolute concentration of histamine to produce a positive test, but individual patients showed a wide spread. Furthermore, the correlation between the initial value of the FEV1 and the bronchial response seemed to be highly significant (p < 0.0001). It is concluded that the HIP is not always reproducible within a short period and that the hyperreactivity of the airways is correlated to the initial value of the FEV1.

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