The effect of histamine on occlusion pressure and electrical activity of the diaphragm was studied in 5 conscious goats under conditions of changing respiratory drive by exposing the animals in separate trials to progressive hypercapnia produced by rebreathing technique. Both electrical activity of the diaphragm and occlusion pressure increased with hypercapnia. At any level of PCO2, occlusion pressure and diaphragm electrical activity were greater after histamine than in the control state at the same level of chemical stimulation. Both parameters changed proportionally, and a linear correlation was found between them (r > 0.9). These results in conscious unsedated animals indicate that (1) histamine causes an increase of inspiratory neuromuscle drive, and (2) occlusion pressure satisfactorily indicates changes in respiratory neuron motor output.

Keywords:
Histamine, Inspiratory neuromuscular drive, Occlusion pressure, Electrical activity of diaphragm, Progressive hypercapnia
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© 1983 S. Karger AG, Basel
1983
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