Responsiveness to anticholinergic bronchodilators was assessed in 19 atopic and in 36 non-atopic asthmatics of comparable mean age and basal FEV1. Atopic subjects had a significantly lower degree of responsiveness (p < 0.01).When the 19 atopic subjects were matched for FEV1 and age with 19 non-atopic subjects (selected from the group of 36) the difference in responsiveness to anticholinergic drugs was still evident (p < 0.01). Atopic status thus appears to have a significant effect on bronchial reactivity to inhaled anticholinergic drugs.

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