In persons with healthy lungs and in patients with chronic pulmonary emphysema, the distribution of ventilation within the lung was assessed by the wash-out and wash-in technique. The evaluation process is designed to enable determination of relative values of ventilation in two functionally uniform lung compartments. A distinction of more than two compartments in the lung is not possible on the basis of wash-in and wash-out studies. Distribution of blood perfusion was estimated from these data and from O2 consumption and arterial O2 saturation. In some healthy subjects, the arterial O2 saturation predicted on the basis of wash-in studies and the assumption of even perfusion is identical with the measured value; in cases where the predicted O2 saturation differs with the measured value there, the less-ventilated alveoli must be underperfused with blood. The discrepancy in the predicted and observed arterial O2 saturation in some emphysema subjects could mean that the poorly ventilated alveoli are contrary relative overperfused with blood

Keywords:
Ventilation, Perfusion distribution in the lung
This content is only available via PDF.
© 1974 S. Karger AG, Basel
1974
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.