In vitro, la bronchomotricité humaine est influencée par l’activité du système adrénergique: l’excitation des récepteurs β relâche la musculature lisse des bronches, tandis que l’activation des récepteurs a s’avère spasmogène. Cette dernière ne se manifeste in vivo, chez les sujets indemnes d’affection allergique qu’à la faveur d’un blocage de l’activité β dont le role apparaît ainsi preponderant. Chez le sujet en état de mal asthmatique se manifeste un déséquilibre du système adrénergique au profit des récepteurs α. Le blocage de ces derniers par la phentolamine possède une action curative. In vitro, le DSCG, médication antiasthmatique, se comporte comme un inhibiteur de l’activité a adrénergique. II apparaît de plus doué d’un effet antagoniste du bronchospasme histaminique.

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© 1970 S. Karger AG, Basel
1970
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