Fourteen cooperative patients with extrinsic asthma (positive history and skin tests with inhalation allergens, sputum eosinophilia, isoprenaline reactive bronchial obstruction) were treated during two weeks with lactose-isoprenaline-powder-inhalations, then during three weeks with DSCG-isoprenaline-powder-inhalations 4 times per day. Other kinds of treatments for asthma were continued; when there was long term steroid treatment, the daily dose remained constant two weeks before and during trial. The subjective symptoms were carefully scored every evening and every morning by the patients. At the end of the control and at the end of the DSCG periods, pulmonary function was investigated at rest, during light and during severe exercise. During the DSCG period, the subjective symptoms improved in statistically highly significant proportions. The following objective measurements did also improve significantly: Vital capacity, FEV1, arterial pO2 and oxygen saturation determined at rest and during light and severe exercise, and the minute ventilation and the physiological dead space measured during light exercise. A significant correlation could be observed between the improvement of the exercise dyspnea and the FEV1 and also between the improvement of the exercise dyspnea and the arterial oxygen saturation found during light exercise.

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© 1970 S. Karger AG, Basel
1970
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