Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread worldwide since December 2019, causing the COVID-19 pandemic. Several measures have taken place in many countries to avoid further spread of the virus and to manage infected people according to disease severity. Notably, telemedicine (TM) was successfully used to manage less severe patients. Our aim was to assess the impact and the edges of using TM in home-isolated or hospitalized patients affected by SARS-CoV-2 infection and its further application. Methods: We performed a systematic review according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines, focusing on randomized controlled trials (RCTs) published in English and available on PubMed database. Full texts were blindly reviewed and then assessed according to PICO model. Results: Our research identified a total of 1,959 records, of which 24 were potentially eligible through the articles full-text review. Six papers were included for data extraction and 18 articles were excluded: 10 articles were not RCTs and 8 articles did not involve SARS-CoV-2 patients. The TM application showed an improvement in psychological stress, mental disorders, and a significant reduction of general stress in patients affected by SARS-CoV-2 infection. The effectiveness of using TM in rehabilitative respiratory programs has been also reported. Furthermore, the benefits of TM application in tailored monitoring of vital parameters in home-isolated patients helped clinicians to early identify a deterioration of clinical conditions. Conclusion: The use of TM during COVID-19 pandemic represented a novel, intriguing, versatile, and useful tool to support clinical practice. This evidence suggests considering TM in a wider range of clinical applications.

Since December 2019, a new respiratory virus, called SARS-CoV-2, has spread worldwide. The subsequent disease, namely COVID-19, caused a wide range of clinical manifestations. Given the great disproportion between the number of cases and healthcare systems’ resources, many countries used telemedicine to manage less severe patients. Telemedicine (TM) is the result of several technologies which allow to remotely collect vital parameters, test results, and provide medical consultation, hesitating in a drastic reduction of direct contacts, a particularly important aspect during a pandemic. By this way, TM helped healthcare professionals in both monitoring patients and taking the most appropriate clinical decisions in a wide range of situations. Furthermore, TM offered the intriguing possibility to adjuvate rehabilitation and provide psychological support. A systematic review focuses on a research question and synthesizes high-quality evidence on the matter. The objective should be to reach a conclusion based on evidence using specific methods. In this systematic review, we assessed the impact of using telemedicine in home-isolated or hospitalized patients affected by COVID-19 and its further potential applications.

1.
Da Rosa Mesquita
R
,
Francelino Silva Junior
LC
,
Santos Santana
FM
,
Farias de Oliveira
T
,
Campos Alcântara
R
,
Monteiro Arnozo
G
.
Clinical manifestations of COVID-19 in the general population: systematic review
.
Wien Klin Wochenschr
.
2021 Apr
133
7–8
377
82
.
2.
Karampitsakos
T
,
Papaioannou
O
,
Tsiri
P
,
Katsaras
M
,
Katsimpris
A
,
Kalogeropoulos
AP
.
Tocilizumab versus baricitinib in hospitalized patients with severe COVID-19: an open-label, randomized controlled trial
.
Clin Microbiol Infect
.
2023 Mar
29
3
372
8
.
3.
Hollander
JE
,
Carr
BG
.
Virtually perfect? Telemedicine for covid-19
.
N Engl J Med
.
2020 Apr 30
382
18
1679
81
.
4.
Black
JRM
,
Bailey
C
,
Przewrocka
J
,
Dijkstra
KK
,
Swanton
C
.
COVID-19: the case for health-care worker screening to prevent hospital transmission
.
Lancet
.
2020 May 2
395
10234
1418
20
. Erratum in: Lancet. 2020 Apr 17.
5.
Portnoy
J
,
Waller
M
,
Elliott
T
.
Telemedicine in the era of COVID-19
.
J Allergy Clin Immunol Pract
.
2020 May
8
5
1489
91
.
6.
Page
MJ
,
McKenzie
JE
,
Bossuyt
PM
,
Boutron
I
,
Hoffmann
TC
,
Mulrow
CD
.
The PRISMA 2020 statement: An updated guideline for reporting systematic reviews
.
BMJ
.
2021 May
71
.
7.
Assessing risk of bias in included studies
. [Internet]. [cited 2023 Jul 10]. Available from: https://handbook-51.cochrane.org/chapter_8/8_assessing_risk_of_bias_in_included_studies.htm.
8.
Wei
N
,
Huang
BC
,
Lu
SJ
,
Hu
JB
,
Zhou
XY
,
Hu
CC
.
Efficacy of internet-based integrated intervention on depression and anxiety symptoms in patients with COVID-19
.
J Zhejiang Univ Sci B
.
2020 May
21
5
400
4
.
9.
Spitzer
RL
,
Kroenke
K
,
Williams
JBW
,
Löwe
B
.
A brief measure for assessing generalized anxiety disorder: the GAD-7
.
Arch Intern Med
.
2006 May
166
10
1092
7
.
10.
Kroenke
K
,
Spitzer
RL
,
Williams
JBW
.
The PHQ-9: validity of a brief depression severity measure
.
J Gen Intern Med
.
2001
;
16
(
9
):
606
13
.
11.
Hamilton
M
.
Development of a rating scale for primary depressive illness
.
Br J Soc Clin Psychol
.
1967 Sep
6
4
278
96
.
12.
Hamilton
M
.
The assessment of anxiety states by rating
.
Br J Med Psychol
.
1959 Mar
32
1
50
5
.
13.
Shaygan
M
,
Yazdani
Z
,
Valibeygi
A
.
The effect of online multimedia psychoeducational interventions on the resilience and perceived stress of hospitalized patients with COVID-19: a pilot cluster randomized parallel-controlled trial
.
BMC Psychiatry
.
2021 Dec
21
1
93
.
14.
Lu
L
,
Anderson
B
,
Ha
R
,
D’Agostino
A
,
Rudman
SL
,
Ouyang
D
.
A language-matching model to improve equity and efficiency of COVID-19 contact tracing
.
Proc Natl Acad Sci USA
.
2021 Oct
118
43
e2109443118
.
15.
Gonzalez-Gerez
JJ
,
Saavedra-Hernandez
M
,
Anarte-Lazo
E
,
Bernal-Utrera
C
,
Perez-Ale
M
,
Rodriguez-Blanco
C
.
Short-term effects of a respiratory telerehabilitation program in confined COVID-19 patients in the acute phase: a pilot study
.
IJERPH
.
2021 Jul
18
14
7511
.
16.
Rodríguez-Blanco
C
,
Bernal-Utrera
C
,
Anarte-Lazo
E
,
Saavedra-Hernandez
M
,
De-La-Barrera- Aranda
E
,
Serrera-Figallo
MA
.
Breathing exercises versus strength exercises through telerehabilitation in coronavirus disease 2019 patients in the acute phase: a randomized controlled trial
.
Clin Rehabil
.
2022 Apr
36
4
486
97
.
17.
Beck
JG
,
Grant
DM
,
Read
JP
,
Clapp
JD
,
Coffey
SF
,
Miller
LM
.
The Impact of Event Scale- Revised: psychometric properties in a sample of motor vehicle accident survivors
.
J Anxiety Disord
.
2008 Jan
22
2
187
98
.
18.
Adly
AS
,
Adly
MS
,
Adly
AS
.
Telemanagement of home-isolated COVID-19 patients using oxygen therapy with noninvasive positive pressure ventilation and physical therapy techniques: randomized clinical trial
.
J Med Internet Res
.
2021 Apr
23
4
e23446
.
19.
Sethi
BA
,
Sethi
A
,
Ali
S
,
Aamir
HS
Impact of Coronavirus disease (COVID-19) pandemic on health professionals: impact of COVID-19 on health professionals
Pak J Med Sci
[Internet]. 2020
May
[citato 2022 Sept 26];36(COVID19-S4). Available from: https://www.pjms.org.pk/index.php/pjms/article/view/2779.
20.
Snoswell
CL
,
Chelberg
G
,
De Guzman
KR
,
Haydon
HH
,
Thomas
EE
,
Caffery
LJ
.
The clinical effectiveness of telehealth: a systematic review of meta-analyses from 2010 to 2019
.
J Telemed Telecare
.
2021 Jun
1357633X2110229
.
21.
Beck
AT
,
Ward
CH
,
Mendelson
M
,
Mock
J
,
Erbaugh
J
.
An inventory for measuring depression
.
Arch Gen Psychiatry
.
1961 Jun
4
6
561
71
.
22.
Julian
LJ
.
Measures of anxiety: state-trait anxiety inventory (STAI), Beck anxiety inventory (BAI), and hospital anxiety and depression scale-anxiety (HADS-A)
.
Arthritis Care Res
.
2011
63 Suppl 11
0 11
S467
72
.
23.
Goodman
WK
,
Price
LH
,
Rasmussen
SA
,
Mazure
C
,
Fleischmann
RL
,
Hill
CL
.
The Yale-Brown obsessive compulsive scale: I. Development, use, and reliability
.
Arch Gen Psychiatry
.
1989 Nov
46
11
1006
11
.
24.
Mahmoud
IAM
Usability of telemedicine in physical therapy rehabilitation: systematic review
JMIR Rehabil Assist Technol
2021 Jun
. Online ahead of print.
25.
Tilahun
B
,
Gashu
KD
,
Mekonnen
ZA
,
Endehabtu
BF
,
Angaw
DA
.
Mapping the role of digital health Technologies in prevention and control of COVID-19 pandemic: review of the literature
.
Yearb Med Inform
.
2021 Aug
30
1
026
37
.
26.
Wijsenbeek
MS
,
Moor
CC
,
Johannson
KA
,
Jackson
PD
,
Khor
YH
,
Kondoh
Y
.
Home monitoring in interstitial lung diseases
.
Lancet Respir Med
.
2023 Jan
11
1
97
110
.
27.
Karampitsakos
T
,
Kalogeropoulou
C
,
Tzilas
V
,
Papaioannou
O
,
Kazantzi
A
,
Koukaki
E
.
Safety and effectiveness of mycophenolate mofetil in interstitial lung diseases: insights from a machine learning radiographic model
.
Respiration
.
2022
;
101
(
3
):
262
71
.
28.
Walsh
SLF
,
Calandriello
L
,
Silva
M
,
Sverzellati
N
.
Deep learning for classifying fibrotic lung disease on high-resolution computed tomography: a case-cohort study
.
Lancet Respir Med
.
2018 Nov
6
11
837
45
.
29.
Malouff
TD
,
TerKonda
SP
,
Knight
D
,
Abu Dabrh
AM
,
Perlman
AI
,
Munipalli
B
.
Physician satisfaction with telemedicine during the COVID-19 pandemic: the mayo clinic Florida experience
.
Mayo Clin Proc Innov Qual Outcomes
.
2021 Aug
5
4
771
82
.
You do not currently have access to this content.