Abstract
Guidelines have recommended endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and endoscopic ultrasound-guided fine-needle aspiration biopsy as initial sampling approaches of mediastinal lymph nodes for lung cancer staging. However, the small sample volume might restrict the diagnostic utility of needle aspiration in certain mediastinal diseases. We have recently shown that transbronchial mediastinal cryobiopsy, which is capable of providing larger amounts of intact tissue, improves diagnostic yield in rare tumors and benign diseases compared to EBUS-TBNA. Here, we present a case of mediastinal nodular lymphocyte predominant Hodgkin lymphoma successfully diagnosed by endoscopic transesophageal cryobiopsy.
References
1.
Herth
FJ
, Rabe
KF
, Gasparini
S
, Annema
JT
. Transbronchial and transoesophageal (ultrasound-guided) needle aspirations for the analysis of mediastinal lesions
. Eur Respir J
. 2006
;28
(6
):1264
–75
. .2.
Gompelmann
D
, Herth
FJ
. Role of endobronchial and endoscopic ultrasound in pulmonary medicine
. Respiration
. 2014
;87
(1
):3
–8
. .3.
Cameron
SE
, Andrade
RS
, Pambuccian
SE
. Endobronchial ultrasound-guided transbronchial needle aspiration cytology: a state of the art review
. Cytopathology
. 2010
;21
(1
):6
–26
. .4.
Zhang
J
, Fu
WL
, Huang
ZS
, Guo
JR
, Li
Q
, Herth
FJF
, Primary mediastinal seminoma achieved by transbronchial mediastinal cryobiopsy
. Respiration
. 2020
;99
(5
):426
–30
. .5.
Zhang
J
, Guo
JR
, Huang
ZS
, Fu
WL
, Wu
XL
, Wu
N
, Transbronchial mediastinal cryobiopsy in the diagnosis of mediastinal lesions: a randomised trial
. Eur Respir J
. 2021
:2100055
. .6.
The American Thoracic Society and The European Respiratory Society
. Pretreatment evaluation of non-small-cell lung cancer. The American Thoracic Society and The European Respiratory Society
. Am J Respir Crit Care Med
. 1997
;156
:320
–32
. .7.
Detterbeck
FC
, Jantz
MA
, Wallace
M
, Vansteenkiste
J
, Silvestri
GA
; American College of Chest Physicians
. Invasive mediastinal staging of lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition)
. Chest
. 2007
;132
(3 Suppl
):202S
–20S
. .8.
Varela-Lema
L
, Fernández-Villar
A
, Ruano-Ravina
A
. Effectiveness and safety of endobronchial ultrasound-transbronchial needle aspiration: a systematic review
. Eur Respir J
. 2009
;33
(5
):1156
–64
. .9.
Hartmann
S
, Eichenauer
DA
. Nodular lymphocyte predominant Hodgkin lymphoma: pathology, clinical course and relation to T-cell/histiocyte rich large B-cell lymphoma
. Pathology
. 2020
;52
(1
):142
–53
. .10.
Bandyopadhyay
D
, Panchabhai
TS
, Mehta
AC
. EBUS-TBNA for the diagnosis of lymphoma. Still an achilles heel
. Ann Am Thorac Soc
. 2015
;12
(9
):1263
–4
. .11.
Dhooria
S
, Mehta
RM
, Madan
K
, Vishwanath
G
, Sehgal
IS
, Chhajed
PN
, A multicenter study on the utility of EBUS-TBNA and EUS-B-FNA in the diagnosis of mediastinal lymphoma
. J Bronchology Interv Pulmonol
. 2019
;26
(3
):199
–209
. .12.
Plönes
T
, Mardanzai
K
, Gafencu
D
, Viehof
J
, Hager
T
, Theegarten
D
, Cytology versus histology in the primary diagnosis of lymphoma located in the mediastinum
. Ann Thorac Surg
. 2019
;108
(1
):244
–8
. .13.
Wahidi
MM
, Herth
F
, Yasufuku
K
, Shepherd
RW
, Yarmus
L
, Chawla
M
, Technical aspects of endobronchial ultrasound-guided transbronchial needle aspiration: CHEST guideline and expert panel report
. Chest
. 2016
;149
(3
):816
–35
. .© 2021 S. Karger AG, Basel
2021
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.
