Background: In idiopathic pulmonary fibrosis (IPF), some physiological parameters measured during a 6-min walk test (6-MWT) impart reliable prognostic information. Sit-to-stand tests (STSTs) are field exercise tests that are easier to implement than the 6-MWT in daily practice. Objectives: The aims of the study were to test the reproducibility and compare 2 STSTs (the 1-min STST [1-STST] and the semi-paced 3-min chair rise test [3-CRT]) in IPF, and to determine if selected physiological parameters (speed of displacement and changes in pulse oxygen saturation [SpO2]) are interchangeable between the STSTs and the 6-MWT. Methods: Thirty-three patients with stable IPF were studied in 3 French expert centers. To test reproducibility, intra-class correlations (ICCs) of parameters measured during tests performed 7–14 days apart were calculated. To test interchangeability, the agreement and correlation of physiological responses measured during STSTs and during 6-MWT were studied. Results: Vertical displacements and changes in SpO2 during both STSTs were reproducible, with ICCs ranging from 0.78 [0.63–0.87] to 0.95 [0.92–0.97]. Vertical displacements during 1-STST and 3-CRT were correlated with 6-MWT distance (correlation coefficients (r) of 0.72 and 0.77, respectively; p < 0.001). Similarly, correlations were found between changes in SpO2 measured during the 2 STSTs and the 6-MWT, with coefficients ranging from 0.73 to 0.91 (p < 0.001). Distance walked and SpO2 during 6-MWT were well estimated from vertical displacement and SpO2 during the 2 STSTs, respectively. Conclusion: The correlations found between the 2 STSTs and the 6-MWT suggest that STSTs may be of interest to assess displacement and exercise-induced changes in SpO2 in IPF patients.

1.
Wijsenbeek
M
,
Cottin
V
.
Spectrum of fibrotic lung diseases
.
N Engl J Med
.
2020 Sept 3
;
383
(
10
):
958
68
. .
2.
Cottin
V
,
Hirani
NA
,
Hotchkin
DL
,
Nambiar
AM
,
Ogura
T
,
Otaola
M
, et al
Presentation, diagnosis and clinical course of the spectrum of progressive-fibrosing interstitial lung diseases
.
Eur Respir Rev
.
2018 Dec 31
;
27
(
150
):
180076
. .
3.
Raghu
G
,
Collard
HR
,
Egan
JJ
,
Martinez
FJ
,
Behr
J
,
Brown
KK
, et al
An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management
.
Am J Respir Crit Care Med
.
2011 Mar 15
;
183
(
6
):
788
824
. .
4.
Ley
B
,
Bradford
WZ
,
Weycker
D
,
Vittinghoff
E
,
du Bois
RM
,
Collard
HR
.
Unified baseline and longitudinal mortality prediction in idiopathic pulmonary fibrosis
.
Eur Respir J
.
2015 May
;
45
(
5
):
1374
81
. .
5.
Bahmer
T
,
Kirsten
AM
,
Waschki
B
,
Rabe
KF
,
Magnussen
H
,
Kirsten
D
, et al
Clinical correlates of reduced physical activity in idiopathic pulmonary fibrosis
.
Respiration
.
2016
;
91
(
6
):
497
502
. .
6.
Sharp
C
,
Adamali
HI
,
Millar
AB
.
A comparison of published multidimensional indices to predict outcome in idiopathic pulmonary fibrosis
.
ERJ Open Res
.
2017 Mar 14
;
3
(
1
). .
7.
Serajeddini
H
,
Rogliani
P
,
Mura
M
.
Multi-dimensional assessment of IPF across a wide range of disease severity
.
Lung
.
2018 Dec
;
196
(
6
):
707
13
.
8.
Nathan
SD
,
du Bois
RM
,
Albera
C
,
Bradford
WZ
,
Costabel
U
,
Kartashov
A
, et al
Validation of test performance characteristics and minimal clinically important difference of the 6-minute walk test in patients with idiopathic pulmonary fibrosis
.
Respir Med
.
2015 Jul
;
109
(
7
):
914
22
. .
9.
Brown
AW
,
Nathan
SD
.
The value and application of the 6-minute-walk test in idiopathic pulmonary fibrosis
.
Ann Am Thorac Soc
.
2018 Jan
;
15
(
1
):
3
10
. .
10.
Flaherty
KR
,
Andrei
AC
,
Murray
S
,
Fraley
C
,
Colby
TV
,
Travis
WD
, et al
Idiopathic pulmonary fibrosis: prognostic value of changes in physiology and six-minute-walk test
.
Am J Respir Crit Care Med
.
2006 Oct 1
;
174
(
7
):
803
9
. .
11.
Singh
SJ
,
Puhan
MA
,
Andrianopoulos
V
,
Hernandes
NA
,
Mitchell
KE
,
Hill
CJ
, et al
An official systematic review of the European Respiratory Society/American Thoracic Society: measurement properties of field walking tests in chronic respiratory disease
.
Eur Respir J
.
2014 Dec
;
44
(
6
):
1447
78
. .
12.
Aguilaniu
B
,
Roth
H
,
Gonzalez-Bermejo
J
,
Jondot
M
,
Maitre
J
,
Denis
F
, et al
A simple semipaced 3-minute chair rise test for routine exercise tolerance testing in COPD
.
Int J Chron Obstruct Pulmon Dis
.
2014
;
9
:
1009
19
. .
13.
Jones
SE
,
Kon
SS
,
Canavan
JL
,
Patel
MS
,
Clark
AL
,
Nolan
CM
, et al
The five-repetition sit-to-stand test as a functional outcome measure in COPD
.
Thorax
.
2013 Nov
;
68
(
11
):
1015
20
. .
14.
Labrecque
PT
,
Harvey
J
,
Nadreau
E
,
Maltais
F
,
Dion
G
,
Saey
D
.
Validation and cardiorespiratory response of the 1-min sit-to-stand test in interstitial lung disease
.
Med Sci Sports Exerc
.
2020 Dec
;
52
(
12
):
2508
14
.
15.
Quanjer
PH
,
Stanojevic
S
,
Cole
TJ
,
Baur
X
,
Hall
GL
,
Culver
BH
, et al
Multi-ethnic reference values for spirometry for the 3-95-yr age range: the global lung function 2012 equations
.
Eur Respir J
.
2012 Dec
;
40
(
6
):
1324
43
. .
16.
Stanojevic
S
,
Graham
BL
,
Cooper
BG
,
Thompson
BR
,
Carter
KW
,
Francis
RW
, et al
Official ERS technical standards: global lung function initiative reference values for the carbon monoxide transfer factor for Caucasians
.
Eur Respir J
.
2017 Sept
;
50
(
3
):
1700010
. .
17.
Degano
B
,
Sitbon
O
,
Savale
L
,
Garcia
G
,
O’Callaghan
DS
,
Jaïs
X
, et al
Characterization of pulmonary arterial hypertension patients walking more than 450 m in 6 min at diagnosis
.
Chest
.
2010 Jun
;
137
(
6
):
1297
303
. .
18.
Briand
J
,
Behal
H
,
Chenivesse
C
,
Wémeau-Stervinou
L
,
Wallaert
B
.
The 1-minute sit-to-stand test to detect exercise-induced oxygen desaturation in patients with interstitial lung disease
.
Ther Adv Respir Dis
.
2018 Jan–Dec
;
12
.1753466618793028. .
19.
Holland
AE
,
Hill
CJ
,
Dowman
L
,
Glaspole
I
,
Goh
N
,
Lee
AL
, et al
Short- and long-term reliability of the 6-minute walk test in people with idiopathic pulmonary fibrosis
.
Respir Care
.
2018 Aug
;
63
(
8
):
994
1001
. .
20.
Kocks
JW
,
Asijee
GM
,
Tsiligianni
IG
,
Kerstjens
HA
,
van der Molen
T
.
Functional status measurement in COPD: a review of available methods and their feasibility in primary care
.
Prim Care Respir J
.
2011 Sept
;
20
(
3
):
269
75
. .
21.
Holland
AE
,
Spruit
MA
,
Troosters
T
,
Puhan
MA
,
Pepin
V
,
Saey
D
, et al
An official European Respiratory Society/American Thoracic Society technical standard: field walking tests in chronic respiratory disease
.
Eur Respir J
.
2014 Dec
;
44
(
6
):
1428
46
. .
22.
Casanova
C
,
Celli
BR
,
Barria
P
,
Casas
A
,
Cote
C
,
de Torres
JP
, et al
The 6-min walk distance in healthy subjects: reference standards from seven countries
.
Eur Respir J
.
2011 Jan
;
37
(
1
):
150
6
. .
23.
Vaidya
T
,
Chambellan
A
,
de Bisschop
C
.
Sit-to-stand tests for COPD: a literature review
.
Respir Med
.
2017 Jul
;
128
:
70
7
. .
24.
Nolan
CM
,
Delogu
V
,
Maddocks
M
,
Patel
S
,
Barker
RE
,
Jones
SE
, et al
Validity, responsiveness and minimum clinically important difference of the incremental shuttle walk in idiopathic pulmonary fibrosis: a prospective study
.
Thorax
.
2018 July
;
73
(
7
):
680
2
. .
25.
Steffen
TM
,
Hacker
TA
,
Mollinger
L
.
Age- and gender-related test performance in community-dwelling elderly people: six-minute walk test, berg balance scale, timed up & go test, and gait speeds
.
Phys Ther
.
2002 Feb
;
82
(
2
):
128
37
.
26.
Nolan
CM
,
Maddocks
M
,
Maher
TM
,
Canavan
JL
,
Jones
SE
,
Barker
RE
, et al
Phenotypic characteristics associated with slow gait speed in idiopathic pulmonary fibrosis
.
Respirology
.
2018 May
;
23
(
5
):
498
506
. .
27.
Csuka
M
,
McCarty
DJ
.
Simple method for measurement of lower extremity muscle strength
.
Am J Med
.
1985 Jan
;
78
(
1
):
77
81
. .
28.
Lord
SR
,
Murray
SM
,
Chapman
K
,
Munro
B
,
Tiedemann
A
.
Sit-to-stand performance depends on sensation, speed, balance, and psychological status in addition to strength in older people
.
J Gerontol A Biol Sci Med Sci
.
2002 Aug
;
57
(
8
):
M539
43
. .
29.
Cottin
V
,
Brown
KK
.
Interstitial lung disease associated with systemic sclerosis (SSc-ILD)
.
Respir Res
.
2019 Jan 18
;
20
(
1
):
13
. .
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