The Diagnostic and Statistical Manual of Mental Disorders’ (5th Edition) Alternative Model of Personality Disorders includes a dimensional trait model to describe individual differences in the manifestation of personality pathology. Empirically derived quantitative trait models of psychopathology address many of the structural problems of classical diagnostic schemes (e.g., nonbinary distributions, excessive comorbidity, and diagnostic heterogeneity). However, they are largely based on the structure of individual differences in the manifestation of psychopathology. In contrast, clinical theories of personality disorder, which are the foundation of intervention efforts, are based on the function of maladaptive behavior. This distinction is akin to the difference between morphology and physiology in the broader biological sciences. A structure-function divide in the focus of empirical and clinical work contributes to a lack of integration and difficulties with translation. Here we discuss this tension and argue for the need to bridge this divide and adopt research efforts that integrate structure and function of personality traits. Specifically, we suggest that between-person structure identifies the principal domains of functioning, but to understand dysfunction personality must be conceptualized and studied as an ensemble of contextualized dynamic processes.

1.
American Psychiatric Association
.
Diagnostic and statistical manual of mental disorders
. 5th ed.
Washington (DC)
:
Author
;
2013
.
2.
Krueger
RF
,
Skodol
AE
,
Livesley
WJ
,
Shrout
PE
,
Huang
Y
.
Synthesizing dimensional and categorical approaches to personality disorders: refining the research agenda for DSM-V Axis II
.
Int J Methods Psychiatr Res
.
2007
;
16
(
S1
Suppl 1
):
S65
73
.
[PubMed]
1049-8931
3.
Zachar
P
,
Krueger
RF
,
Kendler
KS
.
Personality disorder in DSM-5: an oral history
.
Psychol Med
.
2016
Jan
;
46
(
1
):
1
10
.
[PubMed]
0033-2917
4.
Lenzenweger
MF
,
Clarkin
JF
,
Yeomans
FE
,
Kernberg
OF
,
Levy
KN
.
Refining the borderline personality disorder phenotype through finite mixture modeling: implications for classification
.
J Pers Disord
.
2008
Aug
;
22
(
4
):
313
31
.
[PubMed]
0885-579X
5.
Wright
AG
,
Hallquist
MN
,
Morse
JQ
,
Scott
LN
,
Stepp
SD
,
Nolf
KA
, et al.
Clarifying interpersonal heterogeneity in borderline personality disorder using latent mixture modeling
.
J Pers Disord
.
2013
Apr
;
27
(
2
):
125
43
.
[PubMed]
0885-579X
6.
Lilienfeld
SO
,
Waldman
ID
,
Israel
AC
.
A critical examination of the use of the term and concept of comorbidity in psychopathology research
.
Clin Psychol Sci Pract
.
1994
;
1
(
1
):
71
83
. 0969-5893
7.
Verheul
R
,
Widiger
TA
.
A meta-analysis of the prevalence and usage of the personality disorder not otherwise specified (PDNOS) diagnosis
.
J Pers Disord
.
2004
Aug
;
18
(
4
):
309
19
.
[PubMed]
0885-579X
8.
Zachar
P
.
A Metaphysics of Psychopathology
.
Cambridge (MA)
:
The MIT Press
;
2014
.
9.
Zimmerman
M
,
Chelminski
I
,
Young
D
,
Dalrymple
K
,
Martinez
J
.
Does the presence of one feature of borderline personality disorder have clinical significance? Implications for dimensional ratings of personality disorders
.
J Clin Psychiatry
.
2012
Jan
;
73
(
1
):
8
12
.
[PubMed]
0160-6689
10.
Clark
LA
.
Assessment and diagnosis of personality disorder: perennial issues and an emerging reconceptualization
.
Annu Rev Psychol
.
2007
;
58
(
1
):
227
57
.
[PubMed]
0066-4308
11.
Widiger
TA
,
Trull
TJ
.
Plate tectonics in the classification of personality disorder: shifting to a dimensional model
.
Am Psychol
.
2007
Feb-Mar
;
62
(
2
):
71
83
.
[PubMed]
0003-066X
12.
Hopwood
CJ
,
Kotov
R
,
Krueger
RF
,
Watson
D
,
Widiger
TA
,
Althoff
RR
, et al.
The time has come for dimensional personality disorder diagnosis
.
Pers Ment Health
.
2018
Feb
;
12
(
1
):
82
6
.
[PubMed]
1932-8621
13.
Wright
AG
. Factor analytic support for the five-factor model. In:
Widiger
TA
, editor
.
Oxford handbook of the five-factor model
.
Oxford, UK
:
Oxford University Press
;
2017
. pp.
217
42
.
14.
Wright
AG
.
The current state and future of factor analysis in personality disorder research
.
Pers Disord
.
2017
Jan
;
8
(
1
):
14
25
.
[PubMed]
1949-2715
15.
Wright
AG
,
Zimmermann
J
. At the nexus of science and practice: Answering basic clinical questions in personality disorder assessment and diagnosis with quantitative modeling techniques. In:
Huprich
S
, editor
.
Personality disorders: Toward theoretical and empirical integration in diagnosis and assessment
.
Washington (DC)
:
American Psychological Association
;
2015
. pp.
109
44
.
16.
Markon
KE
,
Krueger
RF
,
Watson
D
.
Delineating the structure of normal and abnormal personality: an integrative hierarchical approach
.
J Pers Soc Psychol
.
2005
Jan
;
88
(
1
):
139
57
.
[PubMed]
0022-3514
17.
Krueger
RF
,
Derringer
J
,
Markon
KE
,
Watson
D
,
Skodol
AE
.
Initial construction of a maladaptive personality trait model and inventory for DSM-5
.
Psychol Med
.
2012
Sep
;
42
(
9
):
1879
90
.
[PubMed]
0033-2917
18.
Morey
LC
,
Krueger
RF
,
Skodol
AE
.
The hierarchical structure of clinician ratings of proposed DSM-5 pathological personality traits
.
J Abnorm Psychol
.
2013
Aug
;
122
(
3
):
836
41
.
[PubMed]
0021-843X
19.
Al-Dajani
N
,
Gralnick
TM
,
Bagby
RM
.
A psychometric review of the Personality Inventory for DSM–5 (PID–5): current status and future directions
.
J Pers Assess
.
2016
;
98
(
1
):
62
81
.
[PubMed]
0022-3891
20.
Krueger
RF
,
Markon
KE
.
The role of the DSM-5 personality trait model in moving toward a quantitative and empirically based approach to classifying personality and psychopathology
.
Annu Rev Clin Psychol
.
2014
;
10
(
1
):
477
501
.
[PubMed]
1548-5943
21.
Waugh
MH
,
Hopwood
CJ
,
Krueger
RF
,
Morey
LC
,
Pincus
AL
,
Wright
AG
.
Psychological assessment with the DSM-5 Alternative Model for personality disorders: tradition and innovation
.
Prof Psychol Res Pr
.
2017
Apr
;
48
(
2
):
79
89
.
[PubMed]
0735-7028
22.
World Health Organization
. (
2019
).
International statistical classification of diseases and related health problems
(11th ed.). https://icd.who.int/
23.
Aslinger
EN
,
Manuck
SB
,
Pilkonis
PA
,
Simms
LJ
,
Wright
AG
.
Narcissist or narcissistic? Evaluation of the latent structure of narcissistic personality disorder
.
J Abnorm Psychol
.
2018
Jul
;
127
(
5
):
496
502
.
[PubMed]
0021-843X
24.
Haslam
N
,
Holland
E
,
Kuppens
P
.
Categories versus dimensions in personality and psychopathology: a quantitative review of taxometric research
.
Psychol Med
.
2012
May
;
42
(
5
):
903
20
.
[PubMed]
0033-2917
25.
Wendt
LP
,
Wright
AG
,
Pilkonis
PA
,
Nolte
T
,
Fonagy
P
,
Montague
PR
, et al.
The latent structure of interpersonal problems: validity of dimensional, categorical, and hybrid models
.
J Abnorm Psychol
.
2019
Nov
;
128
(
8
):
823
39
.
[PubMed]
0021-843X
26.
Wright
AG
,
Krueger
RF
,
Hobbs
MJ
,
Markon
KE
,
Eaton
NR
,
Slade
T
.
The structure of psychopathology: toward an expanded quantitative empirical model
.
J Abnorm Psychol
.
2013
Feb
;
122
(
1
):
281
94
.
[PubMed]
0021-843X
27.
Wright
AG
,
Thomas
KM
,
Hopwood
CJ
,
Markon
KE
,
Pincus
AL
,
Krueger
RF
.
The hierarchical structure of DSM-5 pathological personality traits
.
J Abnorm Psychol
.
2012
Nov
;
121
(
4
):
951
7
.
[PubMed]
0021-843X
28.
Wright
AG
,
Simms
LJ
.
On the structure of personality disorder traits: conjoint analyses of the CAT-PD, PID-5, and NEO-PI-3 trait models
.
Pers Disord
.
2014
Jan
;
5
(
1
):
43
54
.
[PubMed]
1949-2715
29.
Kotov
R
,
Krueger
RF
,
Watson
D
,
Achenbach
TM
,
Althoff
RR
,
Bagby
RM
, et al.
The Hierarchical Taxonomy of Psychopathology (HiTOP): A dimensional alternative to traditional nosologies
.
J Abnorm Psychol
.
2017
May
;
126
(
4
):
454
77
.
[PubMed]
0021-843X
30.
Wright
AG
,
Simms
LJ
.
A metastructural model of mental disorders and pathological personality traits
.
Psychol Med
.
2015
Aug
;
45
(
11
):
2309
19
.
[PubMed]
0033-2917
31.
Gunderson
JG
.
Commentary on “Personality traits and the classification of mental disorders: toward a more complete integration in DSM-5 and an empirical model of psychopathology”
.
Pers Disord
.
2010
Apr
;
1
(
2
):
119
22
.
[PubMed]
1949-2715
32.
Meehan
,
K. B.
, &
Clarkin
,
J. F.
(
2015
).
A critical evaluation of moving toward a trait system for personality disorder assessment.
Personality disorders: Toward theoretical and empirical integration in diagnosis and assessment, 85-106.
33.
McWilliams
N
.
Beyond traits: personality as intersubjective themes
.
J Pers Assess
.
2012
;
94
(
6
):
563
70
.
[PubMed]
0022-3891
34.
Herpertz
SC
,
Huprich
SK
,
Bohus
M
,
Chanen
A
,
Goodman
M
,
Mehlum
L
, et al.
The challenge of transforming the diagnostic system of personality disorders
.
J Pers Disord
.
2017
Oct
;
31
(
5
):
577
89
.
[PubMed]
0885-579X
35.
Weinberger
DR
,
Glick
ID
,
Klein
DF
.
Whither Research Domain Criteria (RDoC)?: the good, the bad, and the ugly
.
JAMA Psychiatry
.
2015
Dec
;
72
(
12
):
1161
2
.
[PubMed]
2168-622X
36.
Glover
NG
,
Crego
C
,
Widiger
TA
.
The clinical utility of the Five Factor Model of personality disorder
.
Pers Disord
.
2012
Apr
;
3
(
2
):
176
84
.
[PubMed]
1949-2715
37.
Lowe
JR
,
Widiger
TA
.
Clinicians’ judgments of clinical utility: a comparison of the DSM-IV with dimensional models of general personality
.
J Pers Disord
.
2009
Jun
;
23
(
3
):
211
29
.
[PubMed]
0885-579X
38.
Morey
LC
,
Skodol
AE
,
Oldham
JM
.
Clinician judgments of clinical utility: A comparison of DSM-IV-TR personality disorders and the alternative model for DSM-5 personality disorders
.
J Abnorm Psychol
.
2014
May
;
123
(
2
):
398
405
.
[PubMed]
0021-843X
39.
Samuel
DB
,
Widiger
TA
.
Clinicians’ judgments of clinical utility: a comparison of the DSM-IV and five-factor models
.
J Abnorm Psychol
.
2006
May
;
115
(
2
):
298
308
.
[PubMed]
0021-843X
40.
Samuel
DB
,
Widiger
TA
.
Clinicians’ use of personality disorder models within a particular treatment setting: A longitudinal comparison of temporal consistency and clinical utility
.
Pers Ment Health
.
2011
Feb
;
5
(
1
):
12
28
.
[PubMed]
1932-8621
41.
Chassan
JB
.
On the development of clincial statistical systems for psychiatry
.
Biometrics
.
1959
;
15
(
3
):
396
404
. 0006-341X
42.
Ringwald
WR
,
Sharpe
BM
,
Woods
WC
,
Edershile
EA
,
Wright
AG
. Psychopathology and personality functioning. In:
Rauthmann
JF
, editor
.
Handbook of Personality Dynamics and Processes
.
New York (NY)
:
Elsevier
; [in press].
43.
Titchener
EB
.
The postulates of a structural psychology
.
Philos Rev
.
1898
;
7
(
5
):
449
65
. 0031-8108
44.
Hopwood
CJ
.
Interpersonal dynamics in personality and personality disorders
.
Eur J Pers
.
2018
;
32
(
5
):
499
524
. 0890-2070
45.
Hopwood
CJ
,
Zimmermann
J
,
Pincus
AL
,
Krueger
RF
.
Connecting personality structure and dynamics: towards a more evidence-based and clinically useful diagnostic scheme
.
J Pers Disord
.
2015
Aug
;
29
(
4
):
431
48
.
[PubMed]
0885-579X
46.
Hopwood
CJ
,
Pincus
AL
,
Wright
AG
. The interpersonal situation: Integrating clinical assessment, formulation, and intervention. In:
Samuel
D
,
Lynam
D
, editors
.
Using basic personality research to inform personality pathology
.
New York (NY)
:
Oxford University Press
;
2019
. pp.
94
121
.
47.
Pincus
AL
,
Hopwood
CJ
,
Wright
AG
. The interpersonal situation: An integrative framework for the study of personality, psychopathology, and psychotherapy. In:
Funder
D
,
Rauthmann
JF
,
Sherman
R
, editors
.
Oxford handbook of Psychological Situations. New York
.
Oxford
; [in press].
48.
Williams
TF
,
Simms
LJ
. Th conceptual foundations of descriptive psychopathology. In:
Wright
AG
,
Hallquist
MN
, editors
.
Cambridge handbook of research methods in clinical psychology
.
New York (NY)
:
Cambridge University Press
;
2020
. pp.
33
44
.
49.
Gore
WL
,
Widiger
TA
.
The DSM-5 dimensional trait model and five-factor models of general personality
.
J Abnorm Psychol
.
2013
Aug
;
122
(
3
):
816
21
.
[PubMed]
0021-843X
50.
Thomas
KM
,
Yalch
MM
,
Krueger
RF
,
Wright
AG
,
Markon
KE
,
Hopwood
CJ
.
The convergent structure of DSM-5 personality trait facets and five-factor model trait domains
.
Assessment
.
2013
Jun
;
20
(
3
):
308
11
.
[PubMed]
1073-1911
51.
Wiggins
J
.
A psychological taxonomy of trait-descriptive terms: the interpersonal domain
.
J Pers Soc Psychol
.
1979
;
37
(
3
):
395
412
. 0022-3514
52.
Conway
CC
,
Forbes
MK
,
Forbush
KT
,
Fried
EI
,
Hallquist
MN
,
Kotov
R
, et al.
A hierarchical taxonomy of psychopathology can transform mental health research
.
Perspect Psychol Sci
.
2019
May
;
14
(
3
):
419
36
.
[PubMed]
1745-6916
53.
Widiger
,
T.A.
,
Bach
,
B.
,
Chmielewski
,
M.
,
Clark
,
L.A.
,
DeYoung
,
C.G.
,
Hopwood
,
C.J.
,
Kotov
,
R.
,
Krueger
,
R.F.
,
Miller
,
J.D.
,
Morey
,
L.C.
,
Mullins-Sweatt
,
S.N.
,
Patrick
,
C.J.
,
Pincus
,
A.L.
,
Samuel
,
D.B.
,
Sellbom
,
M.
,
South
,
S.C.
,
Tackett
,
J.L.
,
Watson
,
D.
,
Waugh
,
M.H.
,
Wright
,
A.G.C.
,
Zimmermann
,
J.
,
Bagby
,
R.M.
,
Cicero
,
D.C.
,
Conway
,
C.
,
De Clerq
,
B.
,
Docherty
,
A.R.
,
Eaton
,
N.R.
,
Forbush
,
K.T.
,
Haltigan
,
J.D.
,
Ivanova
,
M.Y.
,
Latzman
,
R.D.
,
Lynam
,
D.R.
,
Markon
,
K.E.
,
Reininghaus
,
U.
, &
Thomas
,
K.M.
(in press).
Criterion A of the AMPD in HiTOP.
Journal of Personality Assessment, 101(4), 345-355.
54.
Pincus
AL
,
Lukowitsky
MR
,
Wright
AG
,
Eichler
WC
.
The interpersonal nexus of persons, situations, and psychopathology
.
J Res Pers
.
2009
;
43
(
2
):
264
5
. 0092-6566
55.
Fleeson
W
.
Toward a structure- and process-integrated view of personality: traits as density distribution of states
.
J Pers Soc Psychol
.
2001
Jun
;
80
(
6
):
1011
27
.
[PubMed]
0022-3514
56.
Fleeson
W
,
Gallagher
P
.
The implications of Big Five standing for the distribution of trait manifestation in behavior: fifteen experience-sampling studies and a meta-analysis
.
J Pers Soc Psychol
.
2009
Dec
;
97
(
6
):
1097
114
.
[PubMed]
0022-3514
57.
Baumert
A
,
Schmitt
M
,
Perugini
M
,
Johnson
W
,
Blum
G
,
Borkenau
P
, et al.
Integrating personality structure, personality process, and personality development
.
Eur J Pers
.
2017
;
31
(
5
):
503
28
. 0890-2070
58.
DeYoung
CG
.
Cybernetic big five theory
.
J Res Pers
.
2015
;
56
:
33
58
. 0092-6566
59.
Fleeson
W
,
Jayawickreme
E
.
Whole trait theory
.
J Res Pers
.
2015
Jun
;
56
:
82
92
.
[PubMed]
0092-6566
60.
Allport
GW
.
Personality: A psychological interpretation
.
Holt
;
1937
.
61.
Moskowitz
D
,
Russell
J
,
Sadikaj
G
,
Sutton
R
.
Measuring People Intensively
.
Can Psychol
.
2009
;
50
(
3
):
131
40
. 0708-5591
62.
Trull
TJ
,
Ebner-Priemer
U
.
Ambulatory assessment
.
Annu Rev Clin Psychol
.
2013
;
9
(
1
):
151
76
.
[PubMed]
1548-5943
63.
Wright
AG
,
Zimmermann
J
.
Applied ambulatory assessment: integrating idiographic and nomothetic principles of measurement
.
Psychol Assess
.
2019
Dec
;
31
(
12
):
1467
80
.
[PubMed]
1040-3590
64.
Trull
TJ
,
Ebner-Priemer
UW
.
Ambulatory assessment in psychopathology research: A review of recommended reporting guidelines and current practices
.
J Abnorm Psychol
.
2020
Jan
;
129
(
1
):
56
63
.
[PubMed]
0021-843X
65.
Wright
AG
,
Simms
LJ
.
Stability and fluctuation of personality disorder features in daily life
.
J Abnorm Psychol
.
2016
Jul
;
125
(
5
):
641
56
.
[PubMed]
0021-843X
66.
Russell
JJ
,
Moskowitz
DS
,
Zuroff
DC
,
Sookman
D
,
Paris
J
.
Stability and variability of affective experience and interpersonal behavior in borderline personality disorder
.
J Abnorm Psychol
.
2007
Aug
;
116
(
3
):
578
88
.
[PubMed]
0021-843X
67.
Trull
TJ
,
Solhan
MB
,
Tragesser
SL
,
Jahng
S
,
Wood
PK
,
Piasecki
TM
, et al.
Affective instability: measuring a core feature of borderline personality disorder with ecological momentary assessment
.
J Abnorm Psychol
.
2008
Aug
;
117
(
3
):
647
61
.
[PubMed]
0021-843X
68.
Sadikaj
G
,
Moskowitz
DS
,
Russell
JJ
,
Zuroff
DC
,
Paris
J
.
Quarrelsome behavior in borderline personality disorder: influence of behavioral and affective reactivity to perceptions of others
.
J Abnorm Psychol
.
2013
Feb
;
122
(
1
):
195
207
.
[PubMed]
0021-843X
69.
Kaurin
,
A.
,
Beeney
,
J.
e.,
Stepp
,
S.D.
,
Scott
,
L.N.
,
Woods
,
W.C.
,
Pilkonis
,
P.A.
, &
Wright
,
A.G.C.
(
2019
). Attachment and borderline personality disorder: Differential effects on daily socio-affective processes. Manuscript submitted for publication.
70.
Wright
AG
,
Stepp
SD
,
Scott
LN
,
Hallquist
MN
,
Beeney
JE
,
Lazarus
SA
, et al.
The effect of pathological narcissism on interpersonal and affective processes in social interactions
.
J Abnorm Psychol
.
2017
Oct
;
126
(
7
):
898
910
.
[PubMed]
0021-843X
71.
Wright
AG
,
Beltz
AM
,
Gates
KM
,
Molenaar
PC
,
Simms
LJ
.
Examining the dynamic structure of daily internalizing and externalizing behavior at multiple levels of analysis
.
Front Psychol
.
2015
Dec
;
6
:
1914
.
[PubMed]
1664-1078
72.
Wright
AG
. (
2019
). Moving from structure to function: Assessing a hierarchy of psychopathology in daily life. Paper presented as part of the symposium Novel approaches to explicating the structure and utility of empirically derived structural models of psychopathology (A. Watts. Chair) at the annual meeting for the Society for Research in Psychopathology, Buffalo, NY.
73.
Insel
T
,
Cuthbert
B
,
Garvey
M
,
Heinssen
R
,
Pine
DS
,
Quinn
K
, et al.
Research domain criteria (RDoC): toward a new classification framework for research on mental disorders
.
Am J Psychiatry
.
2010
Jul
;
167
(
7
):
748
51
.
[PubMed]
0002-953X
74.
Harkness
AR
,
Reynolds
SM
,
Lilienfeld
SO
.
A review of systems for psychology and psychiatry: adaptive systems, personality psychopathology five (PSY-5), and the DSM-5
.
J Pers Assess
.
2014
;
96
(
2
):
121
39
.
[PubMed]
0022-3891
75.
DeYoung
CG
,
Krueger
RF
.
A cybernetic theory of psychopathology
.
Psychol Inq
.
2018
;
29
(
3
):
117
38
. 1047-840X
76.
Depue
RA
,
Lenzenweger
MF
. A neurobehavioral dimensional model. In:
Livesley
WJ
, editor
.
Handbook of personality disorders: Theory, research, and treatment
.
Guilford Press
;
2001
. pp.
136
76
.
77.
Depue
,
R. A.
, &
Lenzenweger
,
M. F.
(
2005
).
A neurobehavioral dimensional model of personality disturbance.
Major theories of personality disorder, 2, 391-453.
78.
Rosoff
PM
.
Healthcare rationing cutoffs and Sorites indeterminacy
.
J Med Philos
.
2019
Jul
;
44
(
4
):
479
506
.
[PubMed]
0360-5310
79.
Zachar
P
,
McNally
RJ
. Vagueness, the sorites paradox, and posttraumatic stress disorder. Vagueness in psychiatry, 169-188. In:
Keil
G
,
Keuck
L
,
Hauswald
R
, editors
.
Vagueness in psychiatry. Oxford University Press, 2017
.
2017
.
80.
Markon
KE
.
How things fall apart: understanding the nature of internalizing through its relationship with impairment
.
J Abnorm Psychol
.
2010
Aug
;
119
(
3
):
447
58
.
[PubMed]
0021-843X
81.
Romanyshyn
AT
. (
2019
, July).
Ontological Classifications and Human Rationality in Bioethics.
In The Journal of Medicine and Philosophy: A Forum for Bioethics and Philosophy of Medicine (Vol. 44, No. 4, pp. 391-402). US: Oxford University Press.
82.
Zachar
P
.
Psychiatric disorders: natural kinds made by the world or practical kinds made by us?
World Psychiatry
.
2015
Oct
;
14
(
3
):
288
90
.
[PubMed]
1723-8617
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.