... each included RCT. The quality was also measured by determining whether studies reported critical methodological aspects such as (1) concealment of treatment allocation; (2) blinding of outcome assessment, and (3) use of intent-to-treat data analyses [ 16 ]. Three judges (B.R.R., J.R.S. and S.P.R...

... methodologies [e.g. 1 , 2 , 3 , 4 , 5 ]. The major focus of most studies of unblinding has been the occurrence of side-effects in the active drug arm, which frequently leads patients and physicians to correctly guess the allocation group [ 1, 2, 3, 4, 5 ]. The frequency with which blinding is unsuccessful...