...Taeho Greg Rhee; Sung Ryul Shim; Kevin J. Manning; Howard A. Tennen; Tyler S. Kaster; Giacomo d’Andrea; Brent P. Forester; Andrew A. Nierenberg; Roger S. McIntyre; David C. Steffens Introduction: Cognitive dysfunction or deficits are common in patients with major depressive disorder (MDD...

... disorders are cases in point, and another example is depression. Furukawa and co-authors, in a long-term study of 44 patients with major depression [ 2 ] (major depressive disorder; MDD) found a marked drop in the Social Adjustment Scale score 6 months after illness onset, without recovery during 10 years...

... of psychotherapy are effective for treating major depressive disorder across groups yet show large within-group differences. Patient personality style is considered a potentially useful variable for treatment matching. Objective: This study is the first experimental test of the interaction between therapeutic...

...Amanda M. Legemaat; Huibert Burger; Gert J. Geurtsen; Marlies Brouwer; Philip Spinhoven; Damiaan Denys; Claudi L. Bockting Introduction: Major depressive disorder (MDD) is common, and recurrence rates are high. Preventive Cognitive Therapy (PCT), has been shown to prolong time to recurrence...

... prescribed dose. Objective: This meta-analysis aimed to find evidence of a dose-response relationship or to the contrary in direct comparisons of different SNRI doses in patients with major depressive disorder. Methods: A systematic literature search for RCTs comparing at least two doses of SNRIs was carried...

...Ta-Wei Guu; David Mischoulon; Jerome Sarris; Joseph Hibbeln; Robert K. McNamara; Kei Hamazaki; Marlene P. Freeman; Michael Maes; Yutaka J. Matsuoka; R.H. Belmaker; Felice Jacka; Carmine Pariante; Michael Berk; Wolfgang Marx; Kuan-Pin Su Major depressive disorder (MDD) is a complex mental illness...

... the emotional processes. Here, we assessed the effect of ω–3 PUFAs on EC levels, which may be the novel targets for the ω–3 PUFAs’ antidepressive effects. Methods: We conducted a 12-week double-blind, nonplacebo, randomized controlled trial. Eighty-eight major depressive disorder (MDD) participants were...

...Sahar Mohamed El-Haggar; Mai AbdelRaouf Eissa; Tarek Mohammed Mostafa; Khaled Sabry El-Attar; Mahmoud Samy Abdallah Background: There is evidence for an association between major depressive disorder (MDD) and both inflammatory and phosphodiesterase (PDE) pathways. This study aimed to evaluate...

... be able to engage more meaningfully in CBT shortly following exposure to ketamine, given the drug's purported cognitive-enhancing effects. Hence we investigated the effects of ketamine on cognitive performance as a secondary aim. Subjects aged 18-65 years with major depressive disorder were...

...André F. Carvalho; Cristiano A. Köhler; André R. Brunoni; Kamilla W. Miskowiak; Nathan Herrmann; Krista L. Lanctôt; Thomas N. Hyphantis; João Quevedo; Brisa S. Fernandes; Michael Berk Background: To aid in the differentiation of individuals with major depressive disorder (MDD) from healthy controls...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Cognitive therapy Depression Major depressive disorder Mindfulness meditation Mindfulness-based psychotherapy...

...Christian Brettschneider; Helei Djadran; Martin Härter; Bernd Löwe; Steffi Riedel-Heller; Hans-Helmut König Background: Major depressive disorder (MDD) causes a massive disease burden worldwide. Cognitive behavioural therapy (CBT) is an important treatment approach for depression. Cost-utility...

...Lynn Boschloo; Robert A. Schoevers; Aartjan T.F. Beekman; Johannes H. Smit; Albert M. van Hemert; Brenda W.J.H. Penninx Background: Much is still unclear about the mechanisms underlying the course of major depressive disorder (MDD). This study aimed to identify risk factors that predict a poor...

... disorder, and is frequently associated with antidepressant use. If replicated, this view of MxD could be considered a valid alternative to the DSM-5 criteria for depression with mixed features. Antidepressants Bipolar disorder Clinical predictors Major depressive disorder Mixed depression...

... (effectiveness) might be diminished by the design of RCTs. The STAR*D trial approached daily practice as much as possible, but still has some properties of an RCT. In this study, we compare results from treatment of major depressive disorder (MDD) in routine clinical practice to those of RCTs and STAR*D. Methods...

...), we predicted that anxious depressed patients would respond as well to CT as nonanxious depressed patients. Method: Adults (n = 523) with recurrent major depressive disorder received 12–14 weeks of CT as part of the Continuation Phase Cognitive Therapy Relapse Prevention Trial. Anxious depressed...

...Maurizio Fava; David Mischoulon; Dan Iosifescu; Janet Witte; Michael Pencina; Martina Flynn; Linda Harper; Michael Levy; Karl Rickels; Mark Pollack Background: We assessed the efficacy of low-dose aripiprazole added to antidepressant therapy (ADT) in major depressive disorder (MDD) patients...

... examined how psychotherapy coupled with pharmacotherapy could produce a long-term protective effect by improving the psychobiological stress response. Methods: The researchers recruited 63 subjects with major depressive disorder (MDD) in an outpatient department of psychiatry at a general hospital...

... by sociodemographic or clinical characteristics of the patient. Clinician-rated Montgomery Åsberg Depressive Rating Scale scores and both patient- and therapist-rated Helping Alliance Questionnaire (HAQ-I) scores were obtained from 567 outpatients with major depressive disorder who received 6 months of combined...

... demonstrated the efficacy of supplemental BDT among patients with major depressive disorders (MDD). The objective of the present study was to explore the efficacy of BDT combined with pharmacotherapy in comparison with pharmacotherapy alone in the treatment of OCD with concurrent MDD. Methods: A 12-month...