.... Cipriani A , Furukawa TA , Salanti G , Chaimani A , Atkinson LZ , Ogawa Y , . Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis . Lancet . 2018...

...Stefanie Kremer; Teresa Wiesinger; Tom Bschor; Christopher Baethge Introduction: Social functioning (SF) is the ability to fulfil one’s social obligations and a key outcome in treatment. Objective: The aim of the study was to estimate the effects of antidepressants on SF in patients with major...

... had they not been placed on a WL. The course of symptoms might also be influenced by use of antidepressant medication (ADM), an issue that remains unexplored in the literature. Objective: In a naturalistic setting, WL symptom change before inpatient psychotherapy (mean weeks of waiting = 22.6...

.... Acute treatment of psychotic unipolar depression generally involves the combination of an antidepressant and an antipsychotic drug or electroconvulsive therapy. There is inadequate information about maintenance treatment of unipolar psychotic depression and acute and chronic treatment of psychotic...

...Mark Zimmerman; Caroline Balling; Iwona Chelminski; Kristy Dalrymple Background: Antidepressants are amongst the most frequently prescribed medications. More than a decade ago, our clinical research group applied a prototypic set of inclusion/exclusion criteria used in an antidepressant efficacy...

...Renske C. Bosman; Ruth C. Waumans; Gabriel E. Jacobs; Richard C. Oude Voshaar; Anna D.T. Muntingh; Neeltje M. Batelaan; Anton J.L.M. van Balkom Background: Following remission of an anxiety disorder or a depressive disorder, antidepressants are frequently discontinued and in the case of symptom...

...Sherry L. Grace; Jose R. Medina-Inojosa; Randal J. Thomas; Heather Krause; Kristin S. Vickers-Douglas; Brian A. Palmer; Francisco Lopez-Jimenez Background: To assess use of antidepressants by class in relation to cardiology practice recommendations, and the association of antidepressant use...

...Markus Dold; Lucie Bartova; Rainer Rupprecht; Siegfried Kasper Background: As many patients with unipolar depression do not respond sufficiently to initial antidepressant monotherapy, a dose increase of the current administered antidepressant (dose escalation, high-dose treatment) is frequently...

...Cora Braun; Tom Bschor; Jeremy Franklin; Christopher Baethge Background: It is unclear whether antidepressants can prevent suicides or suicide attempts, particularly during long-term use. Methods: We carried out a comprehensive review of long-term studies of antidepressants (relapse prevention...

... 2007;115(suppl 433):50-57]; we here report their clinical features and antidepressant-related effects. Results: The most frequent MxD symptoms were: psychic agitation or inner tension (97%), absence of retardation (82%), dramatic description of suffering or weeping spells (53%), talkativeness (49...

...Emanuela Offidani; Giovanni A. Fava; Elena Tomba; Ross J. Baldessarini Background: The prevalence, characteristics and implications of excessive arousal-activation in children and adolescents treated with antidepressants for specific illnesses have not been systematically examined. Methods: We...

... from a ‘masked depression’ were compared to patients with organic pain and coexistent depression, patients with only organic pain, and patients with only depression, in a double-blind placebo-controlled therapeutic trial with mianserin. Although mianserin appeared to have effective antidepressant...

... in psychiatry. Different theoretical concepts are discussed. A closer look is taken at the use of QoL measurements in antidepressant trials. Methods: An analysis was performed on the use of QoL measurement in recent antidepressant trials of duloxetine and escitalopram. Results: QoL measurement was found to have...

.... Major depressive disorder Affective disorders Psychodynamic psychotherapy Psychological treatment Antidepressants There are several controlled studies on the efficacy of short-term psychodynamic psychotherapy (STPP) in psychiatric disorders [ 1,2,3,4 ], but only few of them focus...

...Svein Reseland; Joanna Le Noury; Graham Aldred; David Healy Background: Concerns about the risk-benefit ratio of treatment with antidepressants in the light of recent evidence pointing to a risk of suicide induction during the course of treatment with antidepressants. These concerns have led...

...Ramin Mojtabai Background: The rate of antidepressant treatment in the US has significantly increased in the past decade. There are, however, concerns about undertreatment among traditionally underserved groups and overtreatment in less severely ill individuals. This study examines trends...

... controllability of a panic disorder and the type of treatment provided predicted outcome. Methods: The differential effectiveness of cognitive therapy and antidepressant treatment (paroxetine or clomipramine) was investigated in a sample of 129 panic disorder patients in a 12-week, pretest posttest placebo...

... was undertaken in order to examine rates of reintroduction of antidepressants across pregnancy among a cohort of 54 euthymic pregnant women who had discontinued these medications around the time of conception. Reintroduction of antidepressants was used as a marker suggesting relapse of depression. Results: Forty...

...David Healy Background: There has been a long-standing controversy about the possibility that selective serotonin reuptake inhibitor (SSRI) antidepressants might induce suicidality in some patients. Methods: Starting from the clinical studies that gave rise to this issue, this paper reviews...

...-tolerated oral agent for the treatment of sexual dysfunction of various etiologies. There are no studies that have examined the efficacy of oral sildenafil in PTSD patients with sexual dysfunction. Objective: The current study evaluated the impact of sildenafil added to an ongoing antidepressive treatment...