Background: This systematic review aims to investigate the association between comorbid mental disorders and quality of life (QoL) in patients with chronic medical diseases. Methods: Studies investigating adults with diabetes mellitus, coronary artery disease, asthma, chronic back pain and colorectal cancer were included. Two reviewers independently extracted data and assessed methodological criteria. Effect sizes for QoL scores were analyzed in random-effects meta-analyses. Subgroup and sensitivity analyses were conducted. Results: The database search identified 7,291 references and 65 primary studies were included. Medically ill persons with comorbid mental disorders showed a significantly decreased overall (d = –1.10; 95% CI = –1.34 to –0.86), physical (d = –0.64; 95% CI = –0.74 to –0.53) and psychosocial (d = –1.18; 95% CI = –1.42 to –0.95) QoL compared to persons without mental disorders. Subgroup analyses did not reveal significant differences between the examined medical diseases or mental disorders. Conclusion: The review provides evidence of a substantially reduced psychosocial and physical QoL in medically ill patients with comorbid mental disorders. This patient-reported outcome highlights the importance of recognizing and treating comorbid mental disorders in the medically ill.

Baumeister H, Härter M: Mental disorders in patients with obesity in comparison with healthy probands. Int J Obes 2007;31:1155–1164.
Härter M, Baumeister H, Reuter K, Jacobi F, Hofler M, Bengel J, Wittchen HU: Increased 12-month prevalence rates of mental disorders in patients with chronic somatic diseases. Psychother Psychosom 2007;76:354–360.
Lin EHB, Von Korff M, Alonso J, Angermeyer MC, Anthony J, Bromet E, Bruffaerts R, Gasquet I, de Girolamo G, Gureje O, Haro JM, Karam E, Lara C, Lee S, Levinson D, Ormel JH, Posada-Villa J, Scott K, Watanabe M, Williams D: Mental disorders among persons with diabetes – Results from the World Mental Health Surveys. J Psychosom Res 2008;65:571–580.
Hutter N, Schnurr A, Baumeister H: Health care costs in persons with diabetes mellitus and comorbid mental disorders – A systematic review. Diabetologia 2010;53:2470–2479.
Baumeister H, Härter M: Auswirkungen komorbider psychischer Störungen bei chronischen körperlichen Erkrankungen.Med Psychol 2005;14:175–189.
Barth J, Schumacher M, Herrmann-Lingen C: Depression as a risk factor for mortality in patients with coronary heart disease: a meta-analysis. Psychosom Med 2004;66:802–813.
Rothwell PM: External validity of randomised controlled trials: ‘to whom do the results of this trial apply?’ Lancet 2005;365:82–93.
Morrow AM, Quine S, Loughlin EVO, Craig JC: Different priorities: a comparison of parents’ and health professionals’ perceptions of quality of life in quadriplegic cerebral palsy. Arch Dis Child 2008;93:119–125.
Rothwell PM, McDowell Z, Wong CK, Dorman PJ: Doctors and patients don’t agree: cross sectional study of patients’ and doctors’ perceptions and assessments of disability in multiple sclerosis. BMJ 1997;314:1580–1583.
Brown GC, Brown MM, Sharma S, Brown H, Gozum M, Denton P: Quality of life associated with diabetes mellitus in an adult population. J Diabetes Complications 2000;14:18–24.
Lewis EF, Johnson PA, Johnson W, C, Griffin L, Stevenson LW: Preferences for quality of life or survival expressed by patients with heart failure. J Heart Lung Transplant 2001;20:1016–1024.
Higginson IJ, Carr AJ: Measuring quality of life: using quality of life measures in the clinical setting. BMJ 2001;322:1297–1300.
Baumeister H, Bengel J: Psycho-social correlates of health and health behaviours: challenges and methodological pitfalls. Int J Public Health 2007;52:6–7.
Last JM: A Dictionary of Epidemiology, ed 4. New York, Oxford University Press, 2001.
Bowling A: Current state of the art in quality of life measurement; in Carr AJ, Higginson IJ, Robinson PG (eds): Quality of Life, ed 1. London, BMJ Books, 2003, pp 89–100.
Baumeister H, Balke K, Härter M: Psychiatric and somatic comorbidities are negatively associated with quality of life in physically ill patients. J Clin Epidemiol 2005;58:1090–1100.
Robinson PG, Carr AJ, Higginson IJ: How to choose a quality of life measure; in Carr AJ, Higginson IJ, Robinson PG (eds): Quality of Life, ed 1. London, BMJ Books, 2003, pp 89–100.
Carr AJ, Thompson PW, Kirwan JR: Quality of life measures. Br J Rheumatol 1996;35:275–281.
Wells G, Shea B, O’Connell D, Robertson J, Peterson J, Welch V, Losos M, Tugwell P: Newcastle-Ottawa assessment scale for assessing the quality of nonrandomized studies in meta-analysis. (accessed July 24, 2007).
Stata Statistical Software, Release 9.0. College Station, Stata Corporation, 2005.
Review Manager (RevMan), Version 5.0. Copenhagen, Cochrane Collaboration, 2008.
Ware JE: SF-36 health survey update. Spine 2000;25:3130–3139.
Rosenthal R, Rubin DB: Meta-analytic procedures for combining studies with multiple effect sizes. Psychol Bull 1986;99:400–406.
Ibrahim IA, Beich J, Sidorov J, Gabbay R, Yu L: Measuring outcomes of type 2 diabetes disease management program in an HMO setting. South Med J 2002;95:78–87.
Chia EM, Chia EM, Rochtchina E, Wang JJ, Mitchell P: Utility and validity of the self-administered SF-36: findings from an older population. Ann Acad Med Singapore 2006;35:461–467.
Brorsson B, Ifver J, Hays RD: The Swedish Health-Related Quality of Life Survey (SWED-QUAL). Qual Life Res 1993;2:33–45.
McColl E, Eccles MP, Rousseau NS, Steen IN, Parkin DW, Grimshaw JM: From the generic to the condition-specific?: instrument order effects in Quality of Life Assessment. Med Care 2003;41:777–790.
Garratt AM, Hutchinson A, Russell I, Network for Evidence-Based Practice in Northern and Yorkshire (NEBPINY): The UK version of the Seattle Angina Questionnaire (SAQ-UK): reliability, validity and responsiveness. J Clin Epidemiol 2001;54:907–915.
De Gucht V, Van Elderen T, van der Kamp L, Oldridge N: Quality of life after myocardial infarction: translation and validation of the MacNew Questionnaire for a Dutch population. Qual Life Res 2004;13:1483–1488.
Ribera A, Permanyer-Miralda G, Alonso J, Cascant P, Soriano N, Brotons C: Is psychometric scoring of the McNew Quality of Life after Myocardial Infarction questionnaire superior to the clinimetric scoring? A comparison of the two approaches. Qual Life Res 2006;15:357–365.
Brown N, Melville M, Gray D, Young T, Skene AM, Hampton JR: Comparison of the SF-36 health survey questionnaire with the Nottingham Health Profile in long-term survivors of a myocardial infarction. J Public Health Med 2000;22:167–175.
Hinz A, Klaiberg A, Schumacher J, Brahler E: The psychometric quality of the Nottingham Health Profile (NHP) in the general population. Psychother Psychosom Med Psychol 2003;53:353–358.
Aikens JE, Perkins DW, Piette JD, Lipton B: Association between depression and concurrent type 2 diabetes outcomes varies by diabetes regimen. Diabet Med 2008;25:1324–1329.
Awata S, Bech P, Yoshida S, Hirai M, Suzuki S, Yamashita M, Ohara A, Hinokio Y, Matsuoka H, Oka Y: Reliability and validity of the Japanese version of the World Health Organization-Five Well-Being Index in the context of detecting depression in diabetic patients. Psychiatry Clin Neurosci 2007;61:112–119.
Bell RA, Smith SL, Arcury TA, Snively BM, Stafford JM, Quandt SA: Prevalence and correlates of depressive symptoms among rural older African Americans, Native Americans, and whites with diabetes. Diabetes Care 2005;28:823–829.
Bowser DM, Utz S, Glick D, Harmon R, Rovnyak V: The relationship between diabetes mellitus, depression, and missed appointments in a low-income uninsured population. Diabetes Educ 2009;35:966–977.
Cerrelli F, Manini R, Forlani G, Baraldi L, Melchionda N, Marchesini G: Behavior affects quality of life in type 2 diabetes mellitus. Eat Weight Disord 2005;10:251–257.
Ciechanowski PS, Katon WJ, Russo JE: Depression and diabetes: impact of depressive symptoms on adherence, function, and costs. Arch Intern Med 2000;160:3278–3285.
Eren I, Erdi O, Sahin M: The effect of depression on quality of life of patients with type II diabetes mellitus. Depress Anxiety 2008;25:98–106.
Goldney RD, Phillips PJ, Fisher LJ, Wilson DH: Diabetes, depression, and quality of life: a population study. Diabetes Care 2004;27:1066–1070.
Hänninen JA, Takala JK, Keinänen-Kiukaanniemi SM: Depression in subjects with type 2 diabetes: predictive factors and relation to quality of life. Diabetes Care 1999;22:997–998.
Hutter N, Scheidt-Nave C, Baumeister H: Quality of life and health care utilization in individuals with diabetes mellitus and comorbid mental disorders. Gen Hosp Psychiatry 2009;31:33–35.
Jacobson AM, de GM, Samson JA: The effects of psychiatric disorders and symptoms on quality of life in patients with type I and type II diabetes mellitus. Qual Life Res 1997;6:11–20.
Kenardy J: Disordered eating behaviours in women with type 2 diabetes mellitus. Eat Behav 2001;2:183–192.
Kohen D, Burgess AP, Catalan J, Lant A: The role of anxiety and depression in quality of life and symptom reporting in people with diabetes mellitus. Qual Life Res 1998;7:197–204.
Lee HJ, Chapa D, Kao CW, Jones D, Kapustin J, Smith J, Krichten C, Donner T, Thomas SA, Friedmann E: Depression, quality of life, and glycemic control in individuals with type 2 diabetes. J Am Acad Nurse Pract 2009;21:214–224.
Ludman E, Katon W, Russo J, Simon G, Von Korff M, Lin E, Ciechanowski P, Kinder L: Panic episodes among patients with diabetes. Gen Hosp Psychiatry 2006;28:475–481.
Mannucci E, Ricca V, Bardini G, Rotella CM: Well-being enquiry for diabetics: a new measure of diabetes-related quality of life. Diabetes Nutr Metab 1996;9:89–102.
McCollum M, Ellis SL, Regensteiner JG, Zhang W, Sullivan PW: Minor depression and health status among US adults with diabetes mellitus. Am J Manag Care 2007;13:65–72.
McCollum M, Hansen LS, Lu L, Sullivan PW: Gender differences in diabetes mellitus and effects on self-care activity. Gend Med 2005;2:246–254.
Pibernik-Okanovic M, Peros K, Szabo S, Begic D, Metelko Z: Depression in Croatian type 2 diabetic patients: prevalence and risk factors. A Croatian survey from the European Depression in Diabetes (EDID) Research Consortium. Diabet Med 2005;22:942–945.
Sherbourne CD, Wells KB, Meredith LS, Jackson CA, Camp P: Comorbid anxiety disorder and the functioning and well-being of chronically ill patients of general medical providers. Arch Gen Psychiatry 1996;53:889–895.
Wändell PE: The health related quality of life of diabetic patients with psychiatric disorders. Pract Diabetes Int 1999;16:174–178.
Maddigan SL, Feeny DH, Majumdar SR, Farris KB, Johnson JA: Health Utilities Index mark 3 demonstrated construct validity in a population-based sample with type 2 diabetes. J Clin Epidemiol 2006;59:472–477.
Maddigan SL, Feeny DH, Majumdar SR, Farris KB, Johnson JA: Understanding the determinants of health for people with type 2 diabetes. Am J Public Health 2006;96:1649–1655.
Wexler DJ, Grant RW, Wittenberg E, Bosch JL, Cagliero E, Delahanty L, Blais MA, Meigs JB: Correlates of health-related quality of life in type 2 diabetes. Diabetologia 2006;49:1489–1497.
Burton HJ, Kline SA, Cooper BS, Rabinowitz A, Dodek A: Assessing risk for major depression on patients selected for percutaneous transluminal coronary angioplasty: is it a worthwhile venture? Gen Hosp Psychiatry 2003;25:200–208.
Christian AH, Cheema AF, Smith SC, Mosca L: Predictors of quality of life among women with coronary heart disease. Qual Life Res 2007;16:363–373.
Cohen BE, Marmar CR, Neylan TC, Schiller NB, Ali S, Whooley MA: Posttraumatic stress disorder and health-related quality of life in patients with coronary heart disease: findings from the Heart and Soul Study. Arch Gen Psychiatry 2009;66:1214–1220.
de Jonge P, Spijkerman TA, van den Brink RH, Ormel J: Depression after myocardial infarction is a risk factor for declining health related quality of life and increased disability and cardiac complaints at 12 months. Heart 2006;92:32–39.
Edell-Gustafsson UM, Hetta JE: Anxiety, depression and sleep in male patients undergoing coronary artery bypass surgery. Scand J Caring Sci 1999;13:137–143.
Ellis JJ, Eagle KA, Kline-Rogers EM, Erickson SR: Depressive symptoms and treatment after acute coronary syndrome. Int J Cardiol 2005;99:443–447.
Fauerbach JA, Bush DE, Thombs BD, McCann UD, Fogel J, Ziegelstein RC: Depression following acute myocardial infarction: a prospective relationship with ongoing health and function. Psychosomatics 2005;46:355–361.
Ginzburg K, Solomon Z, Koifman B, Keren G, Roth A, Kriwisky M, Kutz I, David D, Bleich A: Trajectories of posttraumatic stress disorder following myocardial infarction: a prospective study. J Clin Psychol 2003;64:1217–1223.
Grossi G, Perski A, Feleke E, Jakobson U: State anxiety predicts poor psychosocial outcome after coronary bypass surgery. Int J Behav Med 1998;5:1–16.
Lavie CJ, Milani RV, Cassidy MM, Gilliland YE: Effects of cardiac rehabilitation and exercise training programs in women with depression. Am J Cardiol 1999;83:1480–1483.
Lavie CJ, Milani RV: Prevalence of anxiety in coronary patients with improvement following cardiac rehabilitation and exercise training. Am J Cardiol 2004;93:336–339.
Leal A, Paiva C, Hofer S, Amado J, Gomes L, Oldridge N: Evaluative and discriminative properties of the Portuguese MacNew Heart Disease Health-related Quality of Life questionnaire. Qual Life Res 2005;14:2335–2341.
Mallik S, Krumholz HM, Lin ZQ, Kasl SV, Mattera JA, Roumains SA, Vaccarino V: Patients with depressive symptoms have lower health status benefits after coronary artery bypass surgery. Circulation 2005;111:271–277.
Mayou RA, Gill D, Thompson DR, Day A, Hicks N, Volmink J, Neil A: Depression and anxiety as predictors of outcome after myocardial infarction. Psychosom Med 2000;62:212–219.
Milani RV, Lavie CJ, Cassidy MM: Effects of cardiac rehabilitation and exercise training programs on depression in patients after major coronary events. Am Heart J 1996;132:726–732.
Mols F, Martens EJ, Denollet J: Type D personality and depressive symptoms are independent predictors of impaired health status following acute myocardial infarction. Heart 2010;96:30–35.
Parashar S, Rumsfeld JS, Spertus JA, Reid KJ, Wenger NK, Krumholz HM, Amin A, Weintraub WS, Lichtman J, Dawood N, Vaccarino V: Time course of depression and outcome of myocardial infarction. Arch Intern Med 2006;166:2035–2043.
Pedersen SS, Denollet J, Spindler H, Ong ATL, Serruys PW, Erdman RAM, van Domburg RT: Anxiety enhances the detrimental effect of depressive symptoms on health status following percutaneous coronary intervention. J Psychosom Res 2006;61:783–789.
Rumsfeld JS, Magid DJ, Plomondon ME, O’Brien MM, Spertus JA, Every NR, Sales AE: Predictors of quality of life following acute coronary syndromes. Am J Cardiol 2001;88:781–784.
Rumsfeld JS, Magid DJ, Plomondon ME, Sales AE, Grunwald GK, Every NR, Spertus JA: History of depression, angina, and quality of life after acute coronary syndromes. Am Heart J 2003;145:493–499.
Rumsfeld JS, Ho PM, Magid D, McCarthy M, Shroyer AL, MaWhinney S, Grover FL, Hammermeister KE: Predictors of health-related quality of life after coronary artery bypass surgery. Ann Thorac Surg 2004;77:1508–1513.
Ruo B, Rumsfeld JS, Hlatky MA, Liu H, Browner WS, Whooley MA: Depressive symptoms and health-related quality of life: the Heart and Soul Study. JAMA 2003;290:215–221.
Serber ER, Todaro JF, Tilkemeier PL, Niaura R: Prevalence and characteristics of multiple psychiatric disorders in cardiac rehabilitation patients. J Cardiopulm Rehabil Prev 2009;29:161–168.
Soto M, Failde I, Marquez S, Benitez E, Ramos I, Barba A, Lopez F: Physical and mental component summaries score of the SF-36 in coronary patients. Qual Life Res 2005;14:759–768.
Spertus JA, McDonell M, Woodman CL, Fihn SD: Association between depression and worse disease-specific functional status in outpatients with coronary artery disease. Am Heart J 2000;140:105–110.
Steele A, Wade TD: The contribution of optimism and quality of life to depression in an acute coronary syndrome population. Eur J Cardiovasc Nurs 2004;3:231–237.
Thombs BD, Ziegelstein RC, Stewart DE, Abbey SE, Parakh K, Grace SL: Usefulness of persistent symptoms of depression to predict physical health status 12 months after an acute coronary syndrome. Am J Cardiol 2008;101:15–19.
Adams RJ, Wilson DH, Taylor AW, Daly A, Tursan d’Espaignet E, Dal Grande E, Ruffin RE: Psychological factors and asthma quality of life: a population based study. Thorax 2004;59:930–935.
Afari N, Schmaling KB, Barnhart S, Buchwald D: Psychiatric comorbidity and functional status in adult patients with asthma. J Clin Psychol Med Settings 2001;8:245–252.
Deshmukh VM, Toelle BG, Usherwood T, O’Grady B, Jenkins CR: The association of comorbid anxiety and depression with asthma-related quality of life and symptom perception in adults. Respirology 2008;13:695–702.
Eisner MD, Katz PP, Lactao G, Iribarren C: Impact of depressive symptoms on adult asthma outcomes. Ann Allergy Asthma Immunol 2005;94:566–574.
Feldman JM, Lehrer PM, Borson S, Hallstrand TS, Siddique MI: Health care use and quality of life among patients with asthma and panic disorder. J Asthma 2005;42:179–184.
Goethe JW, Maljanian R, Wolf S, Hernandez P, Cabrera Y: The impact of depressive symptoms on the functional status of inner-city patients with asthma. Ann Allergy Asthma Immunol 2001;87:205–210.
Lavoie KL, Cartier A, Labrecque M, Bacon SL, Lemiere C, Malo JL, Lacoste G, Barone S, Verrier P, Ditto B: Are psychiatric disorders associated with worse asthma control and quality of life in asthma patients? Curr Respir Med Rev 2005;99:1249–1257.
Lavoie KL, Bacon SL, Barone S, Cartier A, Ditto B, Labrecque M: What is worse for asthma control and quality of life: depressive disorders, anxiety disorders, or both? Chest 2006;130:1039–1047.
Mancuso CA, Peterson MG, Charlson ME: Effects of depressive symptoms on health-related quality of life in asthma patients. J Gen Intern Med 2000;15:301–110.
Schneider A, Lowe B, Meyer FJ, Biessecker K, Joos S, Szecsenyi J: Depression and panic disorder as predictors of health outcomes for patients with asthma in primary care. Respir Med 2008;102:359–366.
Strine TW, Ford ES, Balluz L, Chapman DP, Mokdad AH: Risk behaviors and health-related quality of life among adults with asthma: the role of mental health status. Chest 2004;126:1849–1854.
Strine TW, Mokdad AH, Balluz LS, Berry JT, Gonzalez O: Impact of depression and anxiety on quality of life, health behaviors, and asthma control among adults in the United States with asthma, 2006. J Asthma 2008;45:123–133.
Wisnivesky JP, Leventhal H, Halm EA: Predictors of asthma-related health care utilization and quality of life among inner-city patients with asthma. J Allergy Clin Immunol 2005;116:636–642.
Yellowlees PM, Ruffin RE: Psychological defenses and coping styles in patients following a life-threatening attack of asthma. Chest 1989;95:1298–1303.
Herr KA, Mobily PR, Smith C: Depression and the experience of chronic back pain: a study of related variables and age differences. Clin J Pain 1993;9:104–114.
LaCaille RA, DeBerard MS, Masters KS, Colledge AL, Bacon W: Presurgical biopsychosocial factors predict multidimensional patient: outcomes of interbody cage lumbar fusion. Spine J 2005;5:71–78.
Sinikallio S, Aalto T, Airaksinen O, Herno A, Kroumler H, Savolainen S, Turunen V, Viinamamlki H: Depression and associated factors in patients with lumbar spinal stenosis. Disabil Rehabil 2006;28:415–422.
Cohen J: A power primer. Psychol Bull 1992;112:155–159.
Baumeister H, Hahn D, Bengel J, Härter M: Lebensqualität von Patienten mit einer chronischen somatischen Erkrankung; in Maurischat C, Morfeld M, Kohlmann T, Bullinger M (eds): Lebensqualität: Nützlichkeit und Psychometrie des Health Survey SF-36/SF-12 in der medizinischen Rehabilitation. Lengerich, Pabst, 2004, pp 151–163.
Fung CH, Hays RD: Prospects and challenges in using patient-reported outcomes in clinical practice. Qual Life Res 2008;17:1297–1302.
Baumeister H, Parker G: A second thought on subtyping major depression. Psychother Psychosom 2010;79:388–389.
Lichtenberg P, Belmaker RH: Subtyping major depressive disorder. Psychother Psychosom 2010;79:131–135.
Bech P: Struggle for subtypes in primary and secondary depression and their mode-specific treatment or healing. Psychother Psychosom 2010;79:331–338.
Pohle K, Domschke K, Roehrs T, Arolt V, Baune BT: Medical comorbidity affects antidepressant treatment response in patients with melancholic depression. Psychother Psychosom 2009;78:359–363.
Baumeister H, Kufner K: It is time to adjust the adjustment disorder category. Cur Opin Psychiatry 2009;22:409–412.
Baumeister H, Maercker A, Casey P: Adjustment disorders with depressed mood: a critique of its DSM-IV and ICD-10 conceptualization and recommendations for the future. Psychopathology 2009;42:139–147.
Lamers F, Jonkers CC, Bosma H, Kempen GI, Meijer JA, Pennix BW, Knottnerus JA, van Eijk JT: A minimal psychological intervention in chronically ill elderly patients with depression: a randomized trial. Psychother Psychosom 2010;79:217–226.
Katon W, Lin EH, Kroenke K: The association of depression and anxiety with medical symptom burden in patients with chronic medical illness. Gen Hosp Psychiatry 2007;29:147–155.
Baune BT, Caniato RN, Arolt V, Berger K: The effects of dysthymic disorder on health-related quality of life and disability days in persons with comorbid medical conditions in the general population. Psychother Psychosom 2009;78:161–166.
Dempster M, Donnelly M, Fitzsimons D: Generic, disease-specific and individualized approaches to measuring health related quality of life among people with heart disease – A comparative analysis. Psychol Health 2002;17:447–457.
De Fruyt J, Demyttenaere K: Quality of life measurement in antidepressant trials. Is there an added value? Psychother Psychosom 2009;78:212–219.
Fava GA, Sonino N: Psychosomatic assessment. Psychother Psychosom 2009;78:333–341.
Wise TN: Diagnostic criteria for psychosomatic research are necessary for DSM V. Psychother Psychosom 2009;78:330–332.
Porcelli P, Bellomo A, Quartesan R, Altamura M, Iuso S, Ciannameo I, Piselli M, Elisei S: Psychosocial functioning in consultation-liaison psychiatry patients: influence of psychosomatic syndromes, psychopathology and somatization. Psychother Psychosom 2009;78:352–358.
Cockram CA, Doros G, de Figueiredo JM: Diagnosis and measurement of subjective incompetence: the clinical hallmark of demoralization. Psychother Psychosom 2009;78:342–345.
Balon R: Cognitive-behavioral therapy, psychotherapy and psychosocial interventions in the medically ill. Psychother Psychosom 2009;78:261–264.
Detmar SB, Muller MJ, Schornagel JH, Wever LD, Aaronson NK: Health-related quality-of-life assessments and patient-physician communication: a randomized controlled trial. JAMA 2002;288:3027–3034.
Mitchell AJ, Rao S, Vaze A: Do primary care physicians have particular difficulty identifying late-life depression? A meta-analysis stratefied by age. Psychother Psychosom 2010;79:285–294.
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