Background: There is growing evidence that chronic exercise is a promising intervention for combating feelings of low energy and fatigue. Although groups with well-defined medical conditions (for example cancer and heart disease) or unexplained fatigue syndromes consistently have reported improved feelings of energy and fatigue after chronic exercise, relatively few exercise training studies have been conducted with people who report persistent fatigue yet neither have a medical condition nor reach diagnostic criteria for an unexplained fatigue syndrome. The purpose of this investigation was to use a randomized controlled design to examine the effects of 6 weeks of chronic exercise training on feelings of energy and fatigue in sedentary, healthy young adults reporting persistent fatigue. Methods: Thirty-six healthy, young adults who reported persistent feelings of fatigue were randomly assigned to a moderate-intensity exercise, low-intensity exercise or no treatment control group. Participants in each condition then visited the exercise laboratory on 18 occasions over a 6-week period. Exercise laboratory visits occurred 3 days per week. Vigor and fatigue mood state scores were obtained at the beginning of the third exercise session each week for 6 weeks. Aerobic fitness was measured before and after intervention. Results: The effect of 6 weeks of exercise training on feelings of fatigue was dependent on exercise intensity; however, the effect on feelings of energy was similar for both the low- and moderate-intensity conditions. The changes in feelings of energy and fatigue were independent of changes in aerobic fitness. Conclusions: Six weeks of low and moderate exercise training performed by sedentary adults without a well-defined medical condition or an unexplained fatigue syndrome but reporting persistent feelings of fatigue resulted in similarly beneficial effects on feelings of energy. The effects for symptoms of fatigue were moderated by exercise intensity, and the more favorable outcome was realized with low-intensity exercise. Changes in feelings of energy and fatigue following exercise training were unrelated to changes in aerobic fitness.

Wessely S, Hotopf M, Sharpe M: Chronic Fatigue and Its Syndromes. Oxford, Oxford University Press, 1998.
Puetz TW: Physical activity and feelings of energy and fatigue: a review of epidemiological evidence. Sports Med 2006;36:767–780.
Puetz TW, Beasman KM, O’Connor PJ: The effect of cardiac rehabilitation exercise programmes on feelings of energy and fatigue: a meta-analysis from 1945–2005. Eur J Cardiovasc Prev Rehabil 2006;13:886–893.
Puetz TW, O’Connor PJ, Dishman RK: The effects of chronic exercise on feelings of energy and fatigue: a quantitative synthesis. Psych Bull 2006;132:866–876.
Schmitz KH, Holtzman J, Courneya KS, Masse LC, Duval S, Kane R: Controlled physical activity trials in cancer survivors: a systematic review and meta-analysis. Cancer Epidemiol Biomarkers Prev 2005;14:1588–1595.
Stevinson C, Lawlor DA, Fox KR: Exercise interventions for cancer patients: systematic review of controlled trials. Cancer Causes Control 2004;15:1035–1056.
Annesi JJ: Relation of rated fatigue and changes in energy after exercise and over 14 weeks in previously sedentary women exercisers. Percept Mot Skills 2002;95:719–727.
Annesi JJ, Gann S, Westcott WW: Preliminary evaluation of a 10-wk. resistance and cardiovascular exercise protocol on physiological and psychological measures for a sample of older women. Percept Mot Skills 2004;98:163–170.
Atlantis E, Chow CM, Kirby A, Fiatarone SM: An effective exercise-based intervention for improving mental health and quality of life measures: a randomized controlled trial. Prev Med 2004;39:424–434.
DiLorenzo TM, Bargman EP, Stucky-Ropp R, Brassington GS, Frensch PA, LaFontaine T: Long-term effects of aerobic exercise on psychological outcomes. Prev Med 1999;28:75–85.
Leppamaki S, Partonen T, Lonnqvist J: Bright-light exposure combined with physical exercise elevates mood. J Affect Disord 2002;72:139–144.
Partonen T, Leppamaki S, Hurme J, Lonnqvist J: Randomized trial of physical exercise alone or combined with bright light on mood and health-related quality of life. Psychol Med 1998;28:1359–1364.
Pronk SJ, Pronk NP, Sisco A, Ingalls DS, Ochoa C: Impact of a daily 10-minute strength and flexibility program in a manufacturing plant. Am J Health Promot 1995;9:175–178.
Joyce J, Hotopf M, Wessely S: The prognosis of chronic fatigue and chronic fatigue syndrome: a systematic review. QJM 1997;90:223–233.
Bazelmans E, Bleijenberg G, Van Der Meer JW, Folgering H: Is physical deconditioning a perpetuating factor in chronic fatigue syndrome? A controlled study on maximal exercise performance and relations with fatigue, impairment and physical activity. Psychol Med 2001;31:107–114.
O’Connor PJ, Puetz TW: Chronic physical activity and feelings of energy and fatigue. Med Sci Sports Exerc 2005;37:299–305.
Moss-Morris R, Sharon C, Tobin R, Baldi JC: A randomized controlled graded exercise trial for chronic fatigue syndrome: outcomes and mechanisms of change. J Health Psychol 2005;10:245–259.
Petajan JH, Gappmaier E, White AT, Spencer MK: Impact of aerobic training on fitness and quality of life in multiple sclerosis. Ann Neurol 1996;39:432–441.
Snell CR, Van Ness JM, Stevens SR: Exercise therapy; in Jason L, Fennell P, Taylor R (eds): Handbook of Chronic Fatigue Syndrome. New York, John Wiley & Sons, 2003, pp 561–579.
Edmonds M, McGuire H, Price J: Exercise therapy for chronic fatigue syndrome. Cochrane Database Syst Rev 2004;3:CD003200.
Blumenthal JA, Williams RS, Needels TL, Wallace AG: Psychological changes accompany aerobic exercise in healthy middle-aged adults. Psychosom Med 1982;44:529–536.
D’Amico EJ, Neilands TB, Zambarano R: Power analysis for multivariate and repeated measures designs: a flexible approach using the SPSS MANOVA procedure. Behav Res Methods Instrum Comput 2001;33:479–484.
Ware JE: SF-36 Health Survey Manual and Interpretation Guide. Lincoln, Quality Metric, 2000.
American College of Sports Medicine: ACSM’s Guidelines for Exercise Testing and Prescription, ed 6. Baltimore, Lippincott Williams & Wilkins, 2000.
Blair SN, Haskell WL, Ho P, Paffenbarger RS, Vranizan KM, Farquhar JW, Wood PD: Assessment of habitual physical activity by a seven-day recall in a community survey and controlled experiments. Am J Epidemiol 1985;122:794–804.
Dishman RK, Steinhardt M: Reliability and concurrent validity for a 7-d re-call of physical activity in college students. Med Sci Sports Exerc 1988;20:14–25.
Zimmerman M, Mattia JI: A self-report scale to help make psychiatric diagnoses: the Psychiatric Diagnostic Screening Questionnaire. Arch Gen Psychiatry 2001;58:787–794.
Zimmerman M, Mattia JI: The Psychiatric Diagnostic Screening Questionnaire: development, reliability and validity. Compr Psychiatry 2001;42:175–189.
Steinhardt MA, Dishman RK: Reliability and validity of expected outcomes and barriers for habitual physical activity. J Occup Med 1989;31:536–546.
Cook DG, O’Connor PJ, Eubanks SA, Smith JC, Lee M: Naturally occurring muscle pain during exercise: assessment and experimental evidence. Med Sci Sports Exerc 1997;29:999–1012.
Borg G: Borg’s Perceived Exertion and Pain Scales. Champaign, Human Kinetics, 1998.
Storer TW, Davis JA, Caiozzo VJ: Accurate prediction of VO2max in cycle ergometry. Med Sci Sports Exerc 1990;22:704–712.
McNair D, Lorr M, Droppleman L: Profile of Mood States Questionnaire. San Diego, EDITS, 1992.
O’Connor P: Evaluation of four highly cited energy and fatigue mood measures. J Psychosom Res 2004;57:435–441.
Kesaniemi YK, Danforth E, Jensen MD, Kopelman PG, Lefebvre P, Reeder BA: Dose-response issues concerning physical activity and health: an evidence-based symposium. Med Sci Sport Exerc 2001;33:S351–358.
Dunn AL, Trivedi MH, O’Neal HA: Physical activity dose-response effects on outcomes of depression and anxiety. Med Sci Sports Exerc 2001;33:S587–S597.
Schwartz AL, Meek PM, Nail LM, Fargo J, Lundquist M, Donofrio M, Grainger M, Throckmorton T, Mateo M: Measurement of fatigue: determining minimally important clinical differences. J Clin Epidemiol 2002;55:239–244.
Fulcher KY, White PD: Randomized controlled trial of graded exercise in patients with the chronic fatigue syndrome. Br Med J 1997;314:1647–1652.
Johnson SK, DeLuca J: Chronic fatigue syndrome and the brain; in DeLuca J (ed): Fatigue as a Window to the Brain. Cambridge, MIT Press, 2005, pp 137–156.
Norcross JC, Guadagnoli E, Prochaska JO: Factor structure of the Profile of Mood States (POMS): two partial replications. J Clin Psychol 1984;40:1270–1277.
Dollins AB, Lynch HJ, Wurtman RJ, Deng MH, Kischka KU, Gleason RE, Lieberman HR: Effect of pharmacological daytime doses of melatonin on human mood and performance. Psychopharmacology 1993;112:490–496.
O’Connor PJ, Morgan WP, Raglin JS: Psychobiologic effects of 3 d of increased training female and male swimmers. Med Sci Sports Exerc 1991;23:1055–1061.
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