This review summarizes the available knowledge on the phenomenology of posttraumatic dreams. Posttraumatic nightmares are reported by up to 70% of individuals suffering from posttraumatic stress disorder (PTSD). An extensive review of polysomnographic studies suggests that neither this high incidence nor the occurrence of posttraumatic nightmares throughout the sleep cycle can be explained by altered REM sleep parameters. The assumption that a reduction of dream recall may serve as a coping mechanism in PTSD patients is questionable. About 50% of posttraumatic dreams comprise exact replications of the traumatic events. Therefore dreams in PTSD do not have stereotypical content. Data characterizing non-replicative posttraumatic dreams and indicating a change in dream content over time must be considered preliminary. Occurrence of posttraumatic dreams is associated with psychopathological developments. Imagery Rehearsal Therapy has repeatedly been proven to be a valuable tool in treating patients suffering from posttraumatic dream disturbance. A deeper knowledge of posttraumatic dreams is essential for any theory of PTSD as well as for a better understanding of the overall function of dreaming.

1.
Ross RJ, Ball WA, Sullivan KA, Caroff SN: Sleep disturbance as the hallmark of posttraumatic stress disorder. Am J Psychiatry 1989;146:697–707.
2.
American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, ed 4. Washington, American Psychiatric Association, 1994.
3.
Sheikh JI, Woodward SH, Leskin GA: Sleep in post-traumatic stress disorder and panic: convergence and divergence. Depress Anxiety 2003;18:187–197.
4.
Harvey AG, Jones C, Schmidt DA: Sleep and posttraumatic stress disorder: a review. Clin Psychol Rev 2003;23:377–407.
5.
Borbely AA, Wittmann L: Sleep, not REM sleep, is the royal road to dreams. Behav Brain Sci 2000;23:911–912.
6.
Foulkes D: Dream research: 1953–1993. Sleep 1996;19:609–624.
7.
Kaminer H, Lavie P: Sleep and dreaming in Holocaust survivors. Dramatic decrease in dream recall in well-adjusted survivors. J Nerv Ment Dis 1991;179:664–669.
8.
Bixler EO, Kales A, Soldatos CR, Kales JD, Healey S: Prevalence of sleep disorders in the Los Angeles metropolitan area. Am J Psychiatry 1979;136:1257–1262.
9.
Cirignotta F, Zucconi M, Mondini S, Lenzi P, Lugaresi E: Enuresis, sleepwalking and nightmares: An epidemological survey in the Republic of San Marino; in Guilleminault C, Lugaresi E (eds): Sleep-Wake Disorders: Natural History, Epidemiology and Long-Term Evolution. New York, Raven Press, 1983:237–241.
10.
Janson C, Gislason T, De Backer W, Plaschke P, Bjornsson E, Hetta J, Kristbjarnason H, Vermeire P, Boman G: Prevalence of sleep disturbances among young adults in three European countries. Sleep 1995;18:589–597.
11.
Stepansky R, Holzinger B, Schmeiser-Rieder A, Saletu B, Kunze M, Zeitlhofer J: Austrian dream behavior: results of a representative population survey. Dreaming 1998;8:23–30.
12.
Kilpatrick DG, Resnick HS, Freedy JR, Pelcovitz D, Resick P, Roth S, van der Kolk B: Posttraumatic stress disorder field trial: evaluation of the PTSD construct – criteria A through E; in Widiger TA, Frances AJ (eds): DSM-IV Sourcebook. Washington, American Psychiatric Press, 1998, pp 803–844.
13.
Neylan TC, Marmar CR, Metzler TJ, Weiss DS, Zatzick DF, Delucchi KL, Wu RM, Schoenfeld FB: Sleep disturbances in the Vietnam generation: findings from a nationally representative sample of male Vietnam veterans. Am J Psychiatry 1998;155:929–933.
14.
Kessler RC, Sonnega A, Bromet E, Hughes M, Nelson CB: Posttraumatic stress disorder in the National Comorbidity Survey. Arch Gen Psychiatry 1995;52:1048–1060.
15.
Leskin GA, Woodward SH, Young HE, Sheikh JI: Effects of comorbid diagnoses on sleep disturbance in PTSD. J Psychiatr Res 2002;36:449–452.
16.
Ohayon MM, Shapiro CM: Sleep disturbances and psychiatric disorders associated with posttraumatic stress disorder in the general population. Compr Psychiatry 2000;41:469–478.
17.
Holen A: A long-term outcome study of survivors from a disaster. The Alexander L. Kielland disaster in perspective. PhD thesis, University of Oslo, 1990.
18.
Schreuder BJ, Kleijn WC, Rooijmans HG: Nocturnal re-experiencing more than forty years after war trauma. J Trauma Stress 2000;13:453–463.
19.
Bonnet M: The perception on sleep onset in insomniacs and normal sleepers; in Bootzin R, Kihlstrom J, Schacter D (eds): Sleep and Cognition. Washington, APA, 1990, pp 148–158.
20.
Germain A, Hall M, Shear K, Buysse D: An ecological valid study of sleep in PTSD. Sleep 2005;28:A310.
21.
Browman C, Cartwright R: The influence of evening activity and psychological state on dream life. J Psychiatr Treat Eval 1982;4:307–311.
22.
Breslau N, Roth T, Burduvali E, Kapke A, Schultz L, Roehrs T: Sleep in lifetime posttraumatic stress disorder: a community-based polysomnographic study. Arch Gen Psychiatry 2004;61:508–516.
23.
Dagan Y, Lavie P, Bleich A: Elevated awakening thresholds in sleep stage 3–4 in war-related post-traumatic stress disorder. Biol Psychiatry 1991;30:618–622.
24.
Dow BM, Kelsoe JR, Gillin JC: Sleep and dreams in Vietnam PTSD and depression. Biol Psychiatry 1996;39:42–50.
25.
Engdahl BE, Eberly RE, Hurwitz TD, Mahowald MW, Blake J: Sleep in a community sample of elderly war veterans with and without posttraumatic stress disorder. Biol Psychiatry 2000;47:520–525.
26.
Germain A, Nielsen TA: Sleep pathophysiology in posttraumatic stress disorder and idiopathic nightmare sufferers. Biol Psychiatry 2003;54:1092–1098.
27.
Glaubmann H, Mikulincer M, Porat A, Wasserman O, Birger M: Sleep of chronic post-traumatic patients. J Trauma Stress 1990;3:255–263.
28.
Greenberg R, Pearlman CA, Gampel D: War neuroses and the adaptive function of REM sleep. Br J Med Psychol 1972;45:27–33.
29.
Hefez A, Metz L, Lavie P: Long-term effects of extreme situational stress on sleep and dreaming. Am J Psychiatry 1987;144:344–347.
30.
Hulse Fuller K, Waters WF, Scott O: An investigation of slow-wave sleep processes in chronic PTSD patients. J Anxiety Disord 1994;8:227–236.
31.
Hurwitz TD, Mahowald MW, Kuskowski M, Engdahl BE: Polysomnographic sleep is not clinically impaired in Vietnam combat veterans with chronic posttraumatic stress disorder. Biol Psychiatry 1998;44:1066–1073.
32.
Klein E, Koren D, Arnon I, Lavie P: No evidence of sleep disturbance in post-traumatic stress disorder: a polysomnographic study in injured victims of traffic accidents. Isr J Psychiatry Relat Sci 2002;39:3–10.
33.
Kramer M, Kinney L: Sleep patterns in trauma victims with disturbed dreaming. Psychiatr J Univ Ott 1988;13:12–16.
34.
Lavie P, Katz N, Pillar G, Zinger Y: Elevated awaking thresholds during sleep: characteristics of chronic war-related posttraumatic stress disorder patients. Biol Psychiatry 1998;44:1060–1065.
35.
Mellman TA, Bustamante V, Fins AI, Pigeon WR, Nolan B: REM sleep and the early development of posttraumatic stress disorder. Am J Psychiatry 2002;159:1696–1701.
36.
Mellman TA, David D, Kulick-Bell R, Hebding J, Nolan B: Sleep disturbance and its relationship to psychiatric morbidity after Hurricane Andrew. Am J Psychiatry 1995;152:1659–1663.
37.
Mellman TA, Knorr BR, Pigeon WR, Leiter JC, Akay M: Heart rate variability during sleep and the early development of posttraumatic stress disorder. Biol Psychiatry 2004;55:953–956.
38.
Mellman TA, Kulick-Bell R, Ashlock LE, Nolan B: Sleep events among veterans with combat-related posttraumatic stress disorder. Am J Psychiatry 1995;152:110–115.
39.
Mellman TA, Kumar A, Kulick-Bell R, Kumar M, Nolan B: Nocturnal/daytime urine noradrenergic measures and sleep in combat-related PTSD. Biol Psychiatry 1995;38:174–179.
40.
Mellman TA, Nolan B, Hebding J, Kulick-Bell R, Dominguez R: A polysomnographic comparison of veterans with combat-related PTSD, depressed men, and non-ill controls. Sleep 1997;20:46–51.
41.
Neylan TC, Lenoci M, Maglione ML, Rosenlicht NZ, Metzler TJ, Otte C, Schoenfeld FB, Yehuda R, Marmar CR: Delta sleep response to metyrapone in post-traumatic stress disorder. Neuropsychopharmacology 2003;28:1666–1676.
42.
Reist C, Kauffmann CD, Haier RJ, Sangdahl C, DeMet EM, Chicz-DeMet A, Nelson JN: A controlled trial of desipramine in 18 men with posttraumatic stress disorder. Am J Psychiatry 1989;146:513–516.
43.
Ross RJ, Ball WA, Dinges DF, Kribbs NB, Morrison AR, Silver SM, Mulvaney FD: Rapid eye movement sleep disturbance in posttraumatic stress disorder. Biol Psychiatry 1994;35:195–202.
44.
Ross RJ, Ball WA, Dinges DF, Kribbs NB, Morrison AR, Silver SM, Mulvaney FD: Motor dysfunction during sleep in posttraumatic stress disorder. Sleep 1994;17:723–732.
45.
Ross RJ, Ball WA, Sanford LD, Morrison AR, Dinges DF, Silver SM, Kribbs NB, Mulvaney FD, Gehrman PR, McGinnis DE: Rapid eye movement sleep changes during the adaptation night in combat veterans with posttraumatic stress disorder. Biol Psychiatry 1999;45:938–941.
46.
Schlosberg A, Benjamin M: Sleep patterns in three acute combat fatigue cases. J Clin Psychiatry 1978;39:546–549.
47.
Vinent MH, Smith CT: REM sleep processes and dream content in posttraumatic stress disorder (abstract). Sleep 2000;23(suppl 2):101.
48.
Woodward SH, Arsenault NJ, Murray C, Bliwise DL: Laboratory sleep correlates of nightmare complaint in PTSD inpatients. Biol Psychiatry 2000;48:1081–1087.
49.
Woodward SH, Friedman MJ, Bliwise DL: Sleep and depression in combat-related PTSD inpatients. Biol Psychiatry 1996;39:182–192.
50.
Woodward SH, Leskin GA, Sheikh JI: Movement during sleep: associations with posttraumatic stress disorder, nightmares, and comorbid panic disorder. Sleep 2002;25:681–688.
51.
Woodward SH, Leskin GA, Sheikh JI: Sleep respiratory concomitants of comorbid panic and nightmare complaint in post-traumatic stress disorder. Depress Anxiety 2003;18:198–204.
52.
Blake DD, Weathers FW, Nagy LM, Kapoulek DG, Charney DS, Keane TM: Clinician-Administered PTSD Scale for DSM-IV, revised. Boston, National Center for Posttraumatic Stress Disorder, 1998.
53.
Spitzer RL, Williams JBW, Gibbon M, First MB: Instruction Manual for the Structured Clinical Interview for DSM-III-R (SCID 5/1/89 revision). New York, New York State Psychiatric Institute, 1989.
54.
Riemann D, Berger M, Voderholzer U: Sleep and depression – results from psychobiological studies: an overview. Biol Psychol 2001;57:67–103.
55.
Kramer M, Kinney L: Vigilance and avoidance during sleep in US Vietnam war veterans with posttraumatic stress disorder. J Nerv Ment Dis 2003;191:685–687.
56.
Gilbertson MW, Gurvits TV, Lasko NB, Orr SP, Pitman RK: Multivariate assessment of explicit memory function in combat veterans with posttraumatic stress disorder. J Trauma Stress 2001;14:413–432.
57.
Felmingham KL, Bryant RA, Kendall C, Gordon E: Event-related potential dysfunction in posttraumatic stress disorder: the role of numbing. Psychiatry Res 2002;109:171–179.
58.
Woodward SH, Arsenault NJ, Michel GE, Santerre CS, Groves WK, Stewart LP: Polysomnographic characteristics of trauma-related nightmares. Sleep 2000;23:356–357.
59.
Fisher C, Byrne J, Edwards A, Kahn E: A psychophysiological study of nightmares. J Am Psychoanal Assoc 1970;18:747–782.
60.
van der Kolk B, Blitz R, Burr W, Sherry S, Hartmann E: Nightmares and trauma: a comparison of nightmares after combat with lifelong nightmares in veterans. Am J Psychiatry 1984;141:187–190.
61.
Schredl M: Continuity between waking and dreaming: a proposal for a mathematical model. Sleep Hypn 2003;5:38–52.
62.
Baylor GW, Cavallero C: Memory sources associated with REM and NREM dream reports throughout the night: a new look at the data. Sleep 2001;24:165–170.
63.
Fosse MJ, Fosse R, Hobson JA, Stickgold RJ: Dreaming and episodic memory: a functional dissociation? J Cogn Neurosci 2003;15:1–9.
64.
Braun AR, Balkin TJ, Wesenten NJ, Carson RE, Varga M, Baldwin P, Selbie S, Belenky G, Herscovitch P: Regional cerebral blood flow throughout the sleep-wake cycle. An H2(15)O PET study. Brain 1997;120:1173–1197.
65.
Rechtschaffen A, Verdone P, Wheaton J: Reports of mental activity during sleep. Can Psychiatr Assoc J 1963;257:409–414.
66.
Brewin CR, Dalgleish T, Joseph S: A dual representation theory of posttraumatic stress disorder. Psychol Rev 1996;103:670–686.
67.
Caskardon MA, Rechtschaffen A: Monitoring and staging human sleep; in Kryger MH, Roth T, Dement WC (eds): Principles and practice of sleep medicine. Philadelphia, Saunders, 1994, pp 943–960.
68.
Lavie P, Kaminer H: Dreams that poison sleep: dreaming in Holocaust survivors. Dreaming 1991;1:11–21.
69.
Strauch I, Meier B: Den Träumen auf der Spur: Zugang zur modernen Traumforschung. Bern, Huber, 2004.
70.
Kahn E, Fisher C, Lieberman L: Dream recall in the normal aged. J Am Geriatr Soc 1969;17:1121–1126.
71.
Weisz R: Dreams of the aged: an EEG study. Psychophysiology 1969;6:267.
72.
Fein G, Feinberg I, Insel TR, Antrobus JS, Price LJ, Floyd TC, Nelson MA: Sleep mentation in the elderly. Psychophysiology 1985;22:218–225.
73.
Kramer M, Schoen LS, Kinney L: The dream experience in dream-disturbed Vietnam veterans; in van der Kolk BA (ed): Posttraumatic Stress Disorder: Psychological and Biological Sequelae. Washington, American Psychiatric Press, 1984, pp 81–95.
74.
Riemann D, Low H, Schredl M, Wiegand M, Dippel B, Berger M: Investigations of morning and laboratory dream recall and content in depressive patients during baseline conditions and under antidepressive treatment with trimipramine. Psychiatr J Univ Ott 1990;15:93–99.
75.
Schredl M: Die nächtliche Traumwelt. Eine Einführung in die psychologische Traumforschung. Stuttgart, Kohlhammer, 1999.
76.
Schreuder BJN, Igreja V, van Dijk J, Kleijn W: Intrusive re-experiencing of chronic strife or war. Adv Psychiatr Treat 2001;7:102–108.
77.
Mellman T, David D, Bustamante V, Torres R, Fins A: Dreams in the acute aftermath of trauma and their relationship to PTSD. J Trauma Stress 2001;14:241–247.
78.
van der Kolk BA, Fisler R: Dissociation and the fragmentary nature of traumatic memories: overview and exploratory study. J Trauma Stress 1995;8:505–526.
79.
Wilmer HA: The healing nightmare: war dreams of Vietnam veterans; in Barrett D (ed): Trauma and Dreams. Boston, Harvard University Press, 2001, pp 85–99.
80.
Schreuder BJ, van Egmond M, Kleijn WC, Visser AT: Daily reports of posttraumatic nightmares and anxiety dreams in Dutch war victims. J Anxiety Disord 1998;12:511–524.
81.
Freed S, Craske MG, Greher MR: Nocturnal panic and trauma. Depress Anxiety 1999;9:141–145.
82.
Moldofsky A, Hefez A, Lue FA, Bowen DI: Sleep, dreams, and symptoms in women following sexual assault vs. men following political torture. Sleep Res 1992;21:146.
83.
Nielsen TA: A review of mentation in REM and NREM sleep: ‘covert’ REM sleep as a possible reconciliation of two opposing models. Behav Brain Sci 2000;23:851–866.
84.
Dement WC, Kahn E, Roffwarg HP: The influence of the laboratory situation on the dreams of the experimental subject. J Nerv Ment Dis 1965;140:119–131.
85.
Wittmann L, Palmy C, Schredl M: NREM sleep dream recall, dream report length and cortical activation. Sleep Hypn 2004;6:54–58.
86.
Domhoff B, Kamiya J: Problems in dream content study with objective indicators. 2. Appearance of experimental situation in laboratory dream narratives. Arch Gen Psychiatry 1964;11:525–528.
87.
Domhoff B, Kamiya J: Problems in dream content study with objective indicators. 1. A comparison of home and laboratory dream reports. Arch Gen Psychiatry 1964;11:519–524.
88.
Foulkes D: Home and laboratory dreams: four empirical studies and a conceptual reevaluation. Sleep 1979;2:233–251.
89.
Hall CS, van de Castle RL: The content analysis of dream. New York, Appleton-Century-Crofts, 1966.
90.
Hartmann E: The Nightmare. New York, Basic Books, 1984.
91.
Weisz R, Foulkes D: Home and laboratory dreams collected under uniform sampling conditions. Psychophysiology 1970;6:588–596.
92.
Cohen DB: Frequency of dream recall estimated by three methods and related to defense preference and anxiety. J Consult Clin Psychol 1969;33:661–667.
93.
Esposito K, Benitez A, Barza L, Mellman T: Evaluation of dream content in combat-related PTSD. J Trauma Stress 1999;12:681–687.
94.
Hartmann E, Basile R: Dream imagery becomes more intense after 9/11/01. Dreaming 2003;13:61–66.
95.
Hartmann E, Zborowski M, Kunzendorf R: The emotion pictured by a dream: an examination of emotions contextualized in dreams. Sleep Hypn 2001;3:33–43.
96.
Hartmann E, Zborowski M, Rosen R, Grace N: Contextualizing images in dreams: more intense after abuse and trauma. Dreaming 2001;11:115–126.
97.
Hartmann E: Nightmare after trauma as paradigm for all dreams: a new approach to the nature and functions of dreaming. Psychiatry 1998;61:223–238.
98.
Schreuder BJ, Kleijn WC: Intrusive phenomena after psychotrauma. IJP Psychiatr Behav Sci 2001;11:29–34.
99.
Terr LC: Children of Chowchilla: a study of psychic trauma. Psychoanal Study Child 1979;34:547–623.
100.
Terr LC: Chowchilla revisited: the effects of psychic trauma four years after a school-bus kidnapping. Am J Psychiatry 1983;140:1543–1550.
101.
Horowitz M, Wilner N, Alvarez W: Impact of Event Scale: a measure of subjective stress. Psychosom Med 1979;41:209–218.
102.
Burstein A: Posttraumatic flashbacks, dream disturbances, and mental imagery. J Clin Psychiatry 1985;46:374–378.
103.
Kroth J, Garcia M, Hallgren M, LeGrue E, Ross M, Scalise J: Perinatal loss, trauma, and dream reports. Psychol Rep 2004;94:877–882.
104.
Schredl M, Pallmer R: Nightmares in children. Prax Kinderpsychol Kinderpsychiatr 1997;46:36–56.
105.
Cellucci AJ, Lawrence PS: The efficacy of systematic desensitization in recurring nightmares. J Behav Ther Exp Psychiatry 1978;9:109–114.
106.
Miller WR, DiPilato M: Treatment of nightmares via relaxation and desensitization: a controlled evaluation. J Consult Clin Psychol 1983;51:870–877.
107.
Krakow B, Kellner R, Pathak D, Lambert L: Imagery rehearsal treatment for chronic nightmares. Behav Res Ther 1995;33:837–843.
108.
Krakow B, Hollifield M, Johnston L, Koss M, Schrader R, Warner TD, Tandberg D, Lauriello J, McBride L, Cutchen L, Cheng D, Emmons S, Germain A, Melendrez D, Sandoval D, Prince H: Imagery rehearsal therapy for chronic nightmares in sexual assault survivors with posttraumatic stress disorder: a randomized controlled trial. JAMA 2001;286:537–545.
109.
Krakow B, Hollifield M, Schrader R, Koss M, Tandberg D, Lauriello J, McBride L, Warner TD, Cheng D, Edmond T, Kellner R: A controlled study of imagery rehearsal for chronic nightmares in sexual assault survivors with PTSD: a preliminary report. J Trauma Stress 2000;13:589–609.
110.
Krakow B, Sandoval D, Schrader R, Keuhne B, McBride L, Yau CL, Tandberg D: Treatment of chronic nightmares in adjudicated adolescent girls in a residential facility. J Adolesc Health 2001;29:94–100.
111.
Forbes D, Phelps A, McHugh T: Treatment of combat-related nightmares using imagery rehearsal: a pilot study. J Trauma Stress 2001;14:433–442.
112.
Krakow B, Johnston L, Melendrez D, Hollifield M, Warner TD, Chavez-Kennedy D, Herlan MJ: An open-label trial of evidence-based cognitive behavior therapy for nightmares and insomnia in crime victims with PTSD. Am J Psychiatry 2001;158:2043–2047.
113.
Neidhardt EJ, Krakow B, Kellner R, Pathak D: The beneficial effects of one treatment session and recording of nightmares on chronic nightmare sufferers. Sleep 1992;15:470–473.
114.
Kellner R, Neidhardt J, Krakow B, Pathak D: Changes in chronic nightmares after one session of desensitization or rehearsal instructions. Am J Psychiatry 1992;149:659–663.
115.
Krakow B, Kellner R, Pathak D, Lambert L: Long-term reduction of nightmares with imagery rehearsal treatment. Behav Cogn Psychother 1996;24:135–148.
116.
Krakow B, Kellner R, Neidhardt J, Pathak D, Lambert L: Imagery rehearsal treatment of chronic nightmares: with a thirty-month follow-up. J Behav Ther Exp Psychiatry 1993;24:325–330.
117.
Forbes D, Phelps AJ, McHugh AF, Debenham P, Hopwood M, Creamer M: Imagery rehearsal in the treatment of posttraumatic nightmares in Australian veterans with chronic combat-related PTSD: 12-month follow-up data. J Trauma Stress 2003;16:509–513.
118.
Germain A, Krakow B, Faucher B, Zadra A, Nielsen T, Hollifield M, Warner TD, Koss M: Increased mastery elements associated with imagery rehearsal treatment for nightmares in sexual assault survivors with PTSD. Dreaming 2004;14:195–206.
119.
Schnyder U: Why new psychotherapies for posttraumatic stress disorder? Psychother Psychosom 2005;74:199–201.
120.
Stickgold R: EMDR: a putative neurobiological mechanism of action. J Clin Psychol 2002;58:61–75.
121.
Wood JM, Bootzin RR, Rosenhan D, Nolen-Hoeksema S, Jourden F: Effects of the 1989 San Francisco earthquake on frequency and content of nightmares. J Abnorm Psychol 1992;101:219–224.
122.
Schredl M: Effects of state and trait factors on nightmare frequency. Eur Arch Psychiatry Clin Neurosci 2003;253:241–247.
123.
Kramer M: Nightmares (dream disturbances) in posttraumatic stress disorder: implications for a theory of dreaming; in Bootzin RR, Kihlstrom JF, Schacter DL (eds): Sleep and Cognition. Washington, APA, 1990, pp 190–202.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.