The author reaches the conclusion that the psychosomatic specificity hypothesis for the etiology of peptic ulcer, which was based on physiological, clinical, psycho-analytical and biographical data, has been shown to be compatible with the results of later physiological, behavioral, epidemiological and sociological observations. There have, however, been too few studies in which predictions derived from the hypothesis were systematically tested by apropriate validated methods. As a result the hypothesis still stands more or less at the same degree of probability as when it was formulated. The author indicates how more direct ways of testing would be possible by animal, clinical-investigative, epidemiological, and psycho-therapeutic studies.

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