Objective: S urgical treatment options are limited for medically and endovascular refractory cerebral venous sinus thrombosis (CVT). We describe the technical feasibility of open, direct sinus thrombectomy in a pediatric patient with medically and endovascular refractory CVT. Methods: A 15-year-old patient with superior sagittal sinus (SSS) thrombosis refractory to medical and endovascular treatment experienced clinical deterioration with the progression of bifrontal hematomas and cerebral edema. The patient was treated surgically with a decompressive hemicraniectomy and burr hole SSS thrombectomy with a Fogarty balloon and direct sinus injection of tissue plasminogen activator. Results: Surgical treatment with decompressive craniotomy and direct sinus thrombectomy was technically feasible with excellent intracranial pressure control, and radiological recanalization of the superior sagittal sinus with a good clinical outcome. Conclusion: Direct surgical sinus thrombectomy is a potential concomitant treatment strategy with decompressive craniectomy for medically refractory CVT in a pediatric setting.

1.
Konakondla
S
,
Schirmer
CM
,
Li
F
,
Geng
X
,
Ding
Y
.
New Developments in the Pathophysiology, Workup, and Diagnosis of Dural Venous Sinus Thrombosis (DVST) and a Systematic Review of Endovascular Treatments
.
Aging Dis
.
2017
Apr
;
8
(
2
):
136
48
.
[PubMed]
2152-5250
2.
Filippidis
A
,
Kapsalaki
E
,
Patramani
G
,
Fountas
KN
.
Cerebral venous sinus thrombosis: review of the demographics, pathophysiology, current diagnosis, and treatment
.
Neurosurg Focus
.
2009
Nov
;
27
(
5
):
E3
.
[PubMed]
1092-0684
3.
Coutinho
JM
,
Majoie
CB
,
Coert
BA
,
Stam
J
.
Decompressive hemicraniectomy in cerebral sinus thrombosis: consecutive case series and review of the literature
.
Stroke
.
2009
Jun
;
40
(
6
):
2233
5
.
[PubMed]
0039-2499
4.
Mokin
M
,
Kan
P
,
Sivakanthan
S
,
Veznedaroglu
E
,
Binning
MJ
,
Liebman
KM
, et al
Endovascular therapy of wake-up strokes in the modern era of stent retriever thrombectomy
.
J Neurointerv Surg
.
2016
Mar
;
8
(
3
):
240
3
.
[PubMed]
1759-8478
5.
Siddiqui
FM
,
Dandapat
S
,
Banerjee
C
,
Zuurbier
SM
,
Johnson
M
,
Stam
J
, et al
Mechanical thrombectomy in cerebral venous thrombosis: systematic review of 185 cases
.
Stroke
.
2015
May
;
46
(
5
):
1263
8
.
[PubMed]
0039-2499
6.
Saposnik
G
,
Barinagarrementeria
F
,
Brown
RD
 Jr
,
Bushnell
CD
,
Cucchiara
B
,
Cushman
M
, et al;
American Heart Association Stroke Council and the Council on Epidemiology and Prevention
.
Diagnosis and management of cerebral venous thrombosis: a statement for healthcare professionals from the American Heart Association/American Stroke Association
.
Stroke
.
2011
Apr
;
42
(
4
):
1158
92
.
[PubMed]
0039-2499
7.
Rahman
M
,
Velat
GJ
,
Hoh
BL
,
Mocco
J
.
Direct thrombolysis for cerebral venous sinus thrombosis
.
Neurosurg Focus
.
2009
Nov
;
27
(
5
):
E7
.
[PubMed]
1092-0684
8.
Gala
NB
,
Agarwal
N
,
Barrese
J
,
Gandhi
CD
,
Prestigiacomo
CJ
.
Current endovascular treatment options of dural venous sinus thrombosis: a review of the literature
.
J Neurointerv Surg
.
2013
Jan
;
5
(
1
):
28
34
.
[PubMed]
1759-8478
9.
Silvis
SM
,
de Sousa
DA
,
Ferro
JM
,
Coutinho
JM
.
Cerebral venous thrombosis
.
Nat Rev Neurol
.
2017
Sep
;
13
(
9
):
555
65
.
[PubMed]
1759-4758
10.
Ferro
JM
,
Canhão
P
.
Cerebral venous sinus thrombosis: update on diagnosis and management
.
Curr Cardiol Rep
.
2014
Sep
;
16
(
9
):
523
.
[PubMed]
1523-3782
11.
Canhão
P
,
Ferro
JM
,
Lindgren
AG
,
Bousser
MG
,
Stam
J
,
Barinagarrementeria
F
;
ISCVT Investigators
.
Causes and predictors of death in cerebral venous thrombosis
.
Stroke
.
2005
Aug
;
36
(
8
):
1720
5
.
[PubMed]
0039-2499
12.
Soyer
B
,
Rusca
M
,
Lukaszewicz
AC
,
Crassard
I
,
Guichard
JP
,
Bresson
D
, et al
Outcome of a cohort of severe cerebral venous thrombosis in intensive care
.
Ann Intensive Care
.
2016
Dec
;
6
(
1
):
29
.
[PubMed]
2110-5820
13.
Lee
SK
,
Mokin
M
,
Hetts
SW
,
Fifi
JT
,
Bousser
MG
,
Fraser
JF
;
Society of NeuroInterventional Surgery
.
Current endovascular strategies for cerebral venous thrombosis: report of the SNIS Standards and Guidelines Committee
.
J Neurointerv Surg
.
2018
Aug
;
10
(
8
):
803
10
.
[PubMed]
1759-8478
14.
Siddiqui
FM
,
Banerjee
C
,
Zuurbier
SM
,
Hao
Q
,
Ahn
C
,
Pride
GL
,
Wasay
M
,
Majoie
CB
,
Liebeskind
D
,
Johnson
M
,
Stam
J
:
Mechanical thrombectomy versus intrasinus thrombolysis for cerebral venous sinus thrombosis: a non-randomized comparison.
Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences
2014
;20:336-344.
15.
Ferro
JM
,
Crassard
I
,
Coutinho
JM
,
Canhão
P
,
Barinagarrementeria
F
,
Cucchiara
B
, et al;
Second International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT 2) Investigators
.
Decompressive surgery in cerebrovenous thrombosis: a multicenter registry and a systematic review of individual patient data
.
Stroke
.
2011
Oct
;
42
(
10
):
2825
31
.
[PubMed]
0039-2499
16.
Zhang
S
,
Zhao
H
,
Li
H
,
You
C
,
Hui
X
.
Decompressive craniectomy in hemorrhagic cerebral venous thrombosis: clinicoradiological features and risk factors
.
J Neurosurg
.
2017
Oct
;
127
(
4
):
709
15
.
[PubMed]
0022-3085
17.
Pizzi
MA
,
Alejos
DA
,
Siegel
JL
,
Kim
BY
,
Miller
DA
,
Freeman
WD
:
Cerebral Venous Thrombosis Associated with Intracranial Hemorrhage and Timing of Anticoagulation after Hemicraniectomy.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
2016
;25:2312-2316.
18.
Ekseth
K
,
Boström
S
,
Vegfors
M
.
Reversibility of severe sagittal sinus thrombosis with open surgical thrombectomy combined with local infusion of tissue plasminogen activator: technical case report
.
Neurosurgery
.
1998
Oct
;
43
(
4
):
960
5
.
[PubMed]
0148-396X
19.
Kourtopoulos
H
,
Christie
M
,
Rath
B
.
Open thrombectomy combined with thrombolysis in massive intracranial sinus thrombosis
.
Acta Neurochir (Wien)
.
1994
;
128
(
1-4
):
171
3
.
[PubMed]
0001-6268
20.
Lee
DJ
,
Ahmadpour
A
,
Binyamin
T
,
Dahlin
BC
,
Shahlaie
K
,
Waldau
B
.
Management and outcome of spontaneous cerebral venous sinus thrombosis in a 5-year consecutive single-institution cohort
.
J Neurointerv Surg
.
2017
Jan
;
9
(
1
):
34
8
.
[PubMed]
1759-8478
21.
Lee
DJ
,
Latchaw
RE
,
Dahlin
BC
,
Dong
PR
,
Verro
P
,
Muizelaar
JP
,
Shahlaie
K
:
Antegrade rheolytic thrombectomy and thrombolysis for superior sagittal sinus thrombosis using burr hole access.
BMJ case reports
2014
;2014
22.
Persson
L
,
Lilja
A
.
Extensive dural sinus thrombosis treated by surgical removal and local streptokinase infusion
.
Neurosurgery
.
1990
Jan
;
26
(
1
):
117
21
.
[PubMed]
0148-396X
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.