Factor XIII deficiency is a rare hemorrhagic disorder that can cause spontaneous intracranial hemorrhage and bleeding after surgery. The diagnosis of factor XIII deficiency is difficult before surgical interventions, because coagulation parameters are normal in these patients. Important clinical findings are postsurgical bleeding and recurrent spontaneous intracranial hematomas. These findings should raise the clinical suspicion of factor XIII deficiency. Therefore, diagnosis of factor XIII deficiency is very important for neurologists and neurosurgeons in terms of reducing mortality and morbidity. We present an 8-month-old female patient who developed subdural hematoma after ventriculoperitoneal shunt surgery but not bleeding after choroid plexus papilloma due to FXIII deficiency.

1.
Neurosurgery
B
.
Turkish Neurosurgery Society Publications
,
2010
:1203-1208.
2.
Pediatric Neurosurgery, Turkish Neurosurgery Society Publications,
2014
:468-469.
3.
Odame
JE
,
Chan
AK
,
Wu
JK
,
Breakey
VR
.
Factor XIII deficiency management: a review of the literature
.
Blood Coagul Fibrinolysis
.
2014
Apr
;
25
(
3
):
199
205
.
[PubMed]
0957-5235
4.
Bay
A
,
Sirikci
A
,
Dogan
A
,
Leblebisatan
G
,
Yilmaz
F
.
Spontaneous acute cerebral hematoma in a child with factor XIII deficiency
.
Pediatr Hematol Oncol
.
2013
Nov
;
30
(
8
):
723
5
.
[PubMed]
0888-0018
5.
Naderi
M
,
Alizadeh
S
,
Kazemi
A
,
Tabibian
S
,
Zaker
F
,
Bamedi
T
, et al.
Central nervous system bleeding in pediatric patients with factor XIII deficiency: a study on 23 new cases
.
Hematology
.
2015
Mar
;
20
(
2
):
112
8
.
[PubMed]
1607-8454
6.
Arishima
H
,
Neishi
H
,
Kikuta
KI
,
Morita
M
,
Hosono
N
,
Yamauchi
T
, et al.
Lobar hemorrhage induced by acquired factor XIII deficiency in a patient with cerebral amyloid angiopathy
.
J Stroke Cerebrovasc Dis
.
2017
Oct
;
26
(
10
):
e203
5
.
[PubMed]
1052-3057
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.