Clear cell meningioma (CCM) is an aggressive meningioma variant with a tendency to early recurrence posing a challenge to its treatment. Although spinal meningiomas are uncommon in children, this rare entity has been described as the most common variant of spinal meningiomas in the pediatric age group. We present the case of a 3-year-old with a confirmed lumbar spine CCM and discuss the problems encountered in the management of this disease.

Scheithauer BW: Tumors of the meninges: proposed modifications of the World Health Organization classification. Acta Neuropathol (Berl) 1990;80:343-354.
Liu PI, Liu GC, Tsai KB, Lin CL, Hsu JS: Intraspinal clear-cell meningioma: case report and review of literature. Surg Neurol 2005;63:285-288.
Park HC, Sohn MJ, Kim EY, Han HS, Park HS: Spinal clear cell meningioma presented with progressive paraparesis in infancy. Childs Nerv Syst 2000;16:607-610.
Zorludemir S, Scheithauer BW, Hirose T, Van Houten C, Miller G, Meyer FB: Clear cell meningioma: a clinicopathologic study of a potentially aggressive variant of meningioma. Am J Surg Pathol 1995;19:493-505.
Heth JA, Kirby P, Menezes AH: Intraspinal familial clear cell meningioma in a mother and child. J Neurosurg 2000;93:317-321.
Jain D, Sharma MC, Sarkar C, Suri V, Garg A, Singh M, et al: Clear cell meningioma, an uncommon variant of meningioma: a clinicopathologic study of nine cases. J Neurooncol 2007;81:315-321.
Dubois A, Sevely A, Boetto S, Delisle MB, Manelfe C: Clear-cell meningioma of the cauda equina. Neuroradiology 1998;40:743-747.
Murakami T, Imoto K, Takebayashi T, Yamashita T: Clear cell meningioma of cauda equina in a 10-year-old child (case report). Tumor Res Exp Clin 2001;36:33-38.
Nakajima H, Uchida K, Kobayashi S, Takamura T, Yayama T, Baba H: Microsurgical excision of multiple clear cell meningiomas of the cauda equina: a case report. Minim Invasive Neurosurg 2009;52:32-35.
Matsui H, Kanamori M, Abe Y, Sakai T, Wakaki K: Multifocal clear cell meningioma in the spine: a case report. Neurosurg Rev 1998;21:171-173.
Colen CB, Rayes M, McClendon J Jr, Rabah R, Ham SD: Pediatric spinal clear cell meningioma: case report. J Neurosurg Pediatr 2009;3:57-60.
Epstein NE, Drexler S, Schneider J: Clear cell meningioma of the cauda equina in an adult: case report and literature review. J Spinal Disord Tech 2005;18:539-543.
Deen HG Jr, Scheithauer BW, Ebersold MJ: Clinical and pathological study of meningiomas of the first two decades of life. J Neurosurg 1982;56:317-322.
Wang XQ, Zeng XW, Zhang BY, Dou YF, Wu JS, Jiang CC, et al: Spinal meningioma in childhood: clinical features and treatment. Childs Nerv Syst 2012;28:129-136.
Brusius CV, Pereira Filho AA, Barnewitz JP, Putten AC, Pitta Pinheiro C, Aesse FF: Intradural spinal meningioma in a 20-month-old female. Pediatr Neurosurg 2008;44:247-252.
Fujii K, Sugita K, Honda T, Ishiwada N, Murakami M, Niimi H: Intradural spinal meningioma in a 5-year-old female. Brain Dev 1995;17:349-351.
Oviedo A, Pang D, Zovickian J, Smith M: Clear cell meningioma: case report and review of the literature. Pediatr Dev Pathol 2005;8:386-390.
Kobayashi Y, Nakamura M, Tsuji O, Iwanami A, Ishii K, Watanabe K, et al: Nondura-based clear cell meningioma of the cauda equina in an adult. J Orthop Sci 2013;18:861-865.
Vural M, Arslantas A, Ciftci E, Artan S, Atasoy MA: An unusual case of cervical clear-cell meningioma in pediatric age. Childs Nerv Syst 2007;23:225-229.
Brastianos PK, Horowitz PM, Santagata S, Jones RT, McKenna A, Getz G, et al: Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations. Nat Genet 2013;45:285-289.
Cances C, Chaix Y, Karsenty C, Boetto S, Sevely A, Delisle MB, Carriere JP: Clear cell meningioma: recurrent intraspinal tumor in a child (in French). Arch Pediatr 1998;5:758-762.
Jallo GI, Kothbauer KF, Silvera VM, Epstein FJ: Intraspinal clear cell meningioma: diagnosis and management: report of two cases. Neurosurgery 2001;48:218-221; discussion 221-222.
Carra S, Drigo P, Gardiman M, Perilongo G, Rigobello L: Clear-cell meningioma in a 22-month-old male: a case report and literature review. Pediatr Neurosurg 2001;34:264-267.
Carra S, Drigo P, Gardiman M, Perilongo G, Rigobello L: Clear cell meningioma in a 22-month-old male: update after five years. Pediatr Neurosurg 2003;38:162-163.
Yu KB, Lim MK, Kim HJ, Suh CH, Park HC, Kim EY, Han HS: Clear-cell meningioma: CT and MR imaging findings in two cases involving the spinal canal and cerebellopontine angle. Korean J Radiol 2002;3:125-129.
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