Aims and Objective: The main aim of the study was to find out the postoperative complications and long-term outcome of cerebrospinal fluid-shunted patients in an infantile age group with a poor socioeconomic background. Material and Methods: A prospective study of 100 cases of infantile hydrocephalus was conducted at Pakistan Institute of Medical Sciences, Islamabad, Pakistan. All selected patients suffering from congenital and post-meningitic hydrocephalus were operated on for ventriculoperitoneal shunt. However, cases of hydrocephalus secondary to myelomeningocele were not included. Patients were followed postoperatively for 2 years. Prior consent for surgery was taken from all parents and the study was approved by the hospital’s academic and ethical council. Results: The majority of patients were brought quite late to the medical facilities because of social taboos and socioeconomic conditions. Early signs and symptoms of hydrocephalus were either ignored or misunderstood. Shunt infection and shunt failure rates remained at 14 and 10%, respectively. 50% of shunt blocks occurred in the first postoperative year and another 50% within 2 years. The highest percentage (40–45%) of death occurred in patients suffering from congenital hydrocephalus, in the first postoperative year. Conclusions: This study concluded that the outcome and prognosis of shunted infantile hydrocephalus in developing countries is suboptimal due to different socioeconomic conditions. However, under such circumstances, careful selection of patients, timely intervention and adherence to meticulous aseptic surgical techniques can alter the prognosis of cerebrospinal fluid-shunted infants.

1.
Pople IK: Hydrocephalus and shunts: what the neurologist should know. J Neurol Neurosurg Psychiatry 2002;73(suppl 1):i17–i22.
2.
Sacar S, Turgut H, Toprak S, et al: A retrospective study of central nervous system shunt infections diagnosed in a university hospital during a 4-year period. BMC Infect Dis 2006;6:43.
3.
Chi JH, Fullerton HJ, Gupta N: Time trends and demographics of deaths from congenital hydrocephalus in children in the United States: National Center for Health Statistics Data, 1979 to 1998. J Neurosurg 2005;103(suppl 2):113–118.
4.
Kang JK, Lee IW: Long-term follow-up of shunting therapy. Childs Nerv Syst 1999;15: 711–717.
5.
Weinzierl MR, Rohde V, Gilsbach JM, et al: Management of hydrocephalus in infants by using shunts with adjustable valves. Neurosurg Pediatr 2008;2:14–18.
6.
Van Landingham M, Nguyen TV, Roberts A, et al: Risk factors of congenital hydrocephalus: a 10-year retrospective study. J Neurol Neurosurg Psychiatry 2009;80:213–217.
7.
Moritake K, Nagai H, Miyazaki T, et al: Nationwide survey of the etiology and associated conditions of prenatally and postnatally diagnosed congenital hydrocephalus in Japan. Neurol Med Chir (Tokyo) 2007;47:448–452.
8.
Rajshekhar V: Management of hydrocephalus in patients with tuberculous meningitis. Neurol India 2009;57:368–374.
9.
Moritake K, Nagai H, Miyazaki T, et al: Analysis of a nationwide survey on treatment and outcomes of congenital hydrocephalus in Japan. Neurol Med Chir (Tokyo) 2007;47:453–460.
10.
Laurence KM, Coates S: The natural history of hydrocephalus. Detailed analysis of 182 unoperated cases. Arch Dis Child 1962;37:345–362.
11.
Acakpo-Satchivi L, Shannon CN, Tubbs RS, et al: Death in shunted hydrocephalic children: a follow-up study. Childs Nerv Syst 2008;24:197–120.
12.
Sainte-Rose C: Hydrocephalus in childhood; in Youmans JR (ed): Neurological Surgery, ed 4. Philadelphia, Saunders, 1996, vol 36, pp 890–926.
13.
Katz MD, Trobe DJ, Muraszko KM, et al: Shunt failure without ventriculomegaly proclaimed by ophthalmic findings. J Neurosurg 1994;81:721–725.
14.
Choux M, Genitori L, Lang D, et al: Shunt implantation: reducing the incidence of shunt infection. J Neurosurg 1992;77:875–880.
15.
Pirotte BJ, Lubansu A, Bruneau M, et al: Sterile surgical technique for shunt placement reduces the shunt infection rate in children: preliminary analysis of a prospective protocol in 115 consecutive procedures. Childs Nerv Syst 2007;23:1251–1261.
16.
Hayhurst C, Cooke R, Williams D, et al: The impact of antibiotic-impregnated catheters on shunt infection in children and neonates. Childs Nerv Syst 2008;24:557–562.
17.
Ritzes R, Roser F, Morgalla M, et al: Do antibiotic-impregnated shunts in hydrocephalus therapy reduce the risk of infection? An observational study in 258 patients. BMC Infect Dis 2007;7:38.
18.
Kan P, Kestle J: Lack of efficacy of antibiotic-impregnated shunt systems in preventing shunt infections in children. Childs Nerv Syst 2007;23:773–777.
19.
Rozzelle CJ, Leonardo J, Li V: Antimicrobial suture wound closure for cerebrospinal fluid shunt surgery: a prospective, double-blinded, randomized controlled trial. J Neurosurg Pediatr 2008;2:111–117.
20.
Wang KW, Chang WN, Shih TY, et al: Infection of cerebrospinal fluid shunts: causative pathogens, clinical features, and outcomes. Jpn J Infect Dis 2004;57:44–48.
21.
James EH: Aggressive management of shunt infection: combined intravenous and intraventricular antibiotic therapy for twelve or less days. Pediatr Neurosurg 2008;44:104–111.
22.
Ragel BT, Browd SR, Schmidt RH: Surgical shunt infection: significant reduction when using intraventricular and systemic antibiotic agents. J Neurosurg 2006;105:242–247.
23.
Ratilal B, Costa J, Sampaio C: Antibiotic prophylaxis for surgical introduction of intracranial ventricular shunts: a systematic review. Neurosurg Pediatr 2008;1:48–56.
24.
Choksey MS, Malik IA: Zero tolerance to shunt infections: can it be achieved? J Neurol Neurosurg Psychiatry 2004;75:87–91.
25.
Thompson DN, Hartley JC, Hayward RD: Shunt infection: is there a near-miss scenario? J Neurosurg 2007;106(suppl 1):15–19.
26.
Dallacasa P, Dappozzo A, Galassi E, et al: Cerebrospinal fluid shunts infections in infants. Childs Nerv Syst 1995;11: 643–648.
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