Aims: The impact of decompressive hemicraniectomy (DCH) on the overall outcome of pediatric brain injury patients has not been fully determined. In this paper, the authors performed a systematic review of patient outcome based on quality of life following DCH in a pediatric population. Methods: We describe our experience with decompressive craniectomy in pediatric patients and perform a literature review and pooled outcomes analysis to supplement these findings. A total of 13 children underwent DCH for intractable intracranial pressure in our institution from 2000 to 2008. Follow-up was available in 11 patients with 1 death (9%) and 7 survivors (70%) obtaining a favorable outcome (Glasgow Outcome Scale, GOS, scores = 4–5). Results: A literature review to determine the usefulness of DCH identified 17 articles that, when combined with our series, resulted in 186 pediatric DCH cases. Pooled outcomes found 42 deaths and 112 patients who had favorable outcomes at 6 months. The average 6-month mortality was 21.1%, and the pooled mean quality of life among survivors 0.75 (0.68–0.82), midway between moderate disability and good outcome. Conclusions: Based on our findings, DCH results in a majority of pediatric patients having a good outcome based on the GOS score.

1.
Graham DI, Ford I, Adams JH, Doyle D, Lawrence AE, McLellan DR, et al: Fatal head injury in children. J Clin Pathol 1989;42:18–22.
2.
Aldrich EF, Eisenberg HM, Saydjari C, Luerssen TG, Foulkes MA, Jane JA, et al: Diffuse brain swelling in severely head-injured children: a report from the NIH Traumatic Coma Data Bank. J Neurosurg 1992;76:450–454.
3.
Kirkness CJ, Burr RL, Cain KC, Newell DW, Mitchell PH: Relationship of cerebral perfusion pressure levels to outcome in traumatic brain injury. Acta Neurochir Suppl 2005;95:13–16.
4.
Narayan RK, Kishore PR, Becker DP, Ward JD, Enas GG, Greenberg RP, et al: Intracranial pressure: to monitor or not to monitor? A review of our experience with severe head injury. J Neurosurg 1982;56:650–659.
5.
Cushing H: Subtemporal decompressive operations for the intracranial complications associated with bursting fractures of the skull. Ann Surg 1908;47:641–644.
6.
Ransohoff J, Benjamin MV, Gage EL Jr, Epstein F: Hemicraniectomy in the management of acute subdural hematoma. J Neurosurg 1971;34:70–76.
7.
Kjellberg RN, Prieto A Jr: Bifrontal decompressive craniotomy for massive cerebral edema. J Neurosurg 1971;34:488–493.
8.
Crouchman M, Rossiter L, Colaco T, Forsyth R: A practical outcome scale for paediatric head injury. Arch Dis Child 2001;84:120–124.
9.
Aoki N, Kitahara T, Fukui T, Beck JR, Soma K, Yamamoto W, et al: Management of unruptured intracranial aneurysm in Japan: a Markovian decision analysis with utility measurements based on the Glasgow Outcome Scale. Med Decis Making 1998;18:357–364.
10.
Gold M, Siegel J, Russell L, Weinstein M: Cost-Effectiveness in Health and Medicine. New York, Oxford University Press, 1996.
11.
Berger S, Schwarz M, Huth R: Hypertonic saline solution and decompressive craniectomy for treatment of intracranial hypertension in pediatric severe traumatic brain injury. J Trauma 2002;53:558–563.
12.
Figaji AA, Fieggen AG, Peter JC: Early decompressive craniotomy in children with severe traumatic brain injury. Childs Nerv Syst 2003;19:666–673.
13.
Dam Hieu P, Sizun J, Person H, Besson G: The place of decompressive surgery in the treatment of uncontrollable post-traumatic intracranial hypertension in children. Childs Nerv Syst 1996;12:270–275.
14.
Cho DY, Wang YC, Chi CS: Decompressive craniotomy for acute shaken/impact baby syndrome. Pediatr Neurosurg 1995;23:192–198.
15.
Hejazi N, Witzmann A, Fae P: Unilateral decompressive craniectomy for children with severe brain injury: report of seven cases and review of the relevant literature. Eur J Pediatr 2002;161:99–104.
16.
Jagannathan J, Okonkwo DO, Dumont AS, Ahmed H, Bahari A, Prevedello DM, et al: Outcome following decompressive craniectomy in children with severe traumatic brain injury: a 10-year single-center experience with long-term follow-up. J Neurosurg 2007;106:268–275.
17.
Josan VA, Sgouros S: Early decompressive craniectomy may be effective in the treatment of refractory intracranial hypertension after traumatic brain injury. Childs Nerv Syst 2006;22:1268–1274.
18.
Kan P, Amini A, Hansen K, White GL Jr, Brockmeyer DL, Walker ML, et al: Outcomes after decompressive craniectomy for severe traumatic brain injury in children. J Neurosurg 2006;105:337–342.
19.
Messing-Junger AM, Marzog J, Wobker G, Sabel M, Bock WJ: Decompressive craniectomy in severe brain injury. Zentralbl Neurochir 2003;64:171–177.
20.
Morgalla MH, Krasznai L, Buchholz R, Bitzer M, Deusch H, Walz GU, et al: Repeated decompressive craniectomy after head injury in children: two successful cases as result of improved neuromonitoring. Surg Neurol 1995;43:583–589, discussion 589–590.
21.
Mukherjee KK, Mohindra S, Gupta SK, Gupta R, Khosla VK: True hemicranial decompression for severe pediatric cranial trauma: a short series of 4 cases and literature review. Surg Neurol 2006;66:305–310.
22.
Polin RS, Shaffrey ME, Bogaev CA, Tisdale N, Germanson T, Bocchicchio B, et al: Decompressive bifrontal craniectomy in the treatment of severe refractory posttraumatic cerebral edema. Neurosurgery 1997;41:84–92.
23.
Ruf B, Heckmann M, Schroth I, Hugens-Penzel M, Reiss I, Borkhardt A, et al: Early decompressive craniectomy and duraplasty for refractory intracranial hypertension in children: results of a pilot study. Crit Care 2003;7:R133–R138.
24.
Rutigliano D, Egnor MR, Priebe CJ, McCormack JE, Strong N, Scriven RJ, et al: Decompressive craniectomy in pediatric patients with traumatic brain injury with intractable elevated intracranial pressure. J Pediatr Surg 2006;41:83–87.
25.
Simma B, Tscharre A, Hejazi N, Krasznai L, Fae P: Neurologic outcome after decompressive craniectomy in children. Intensive Care Med 2002;28:1000.
26.
Taylor A, Butt W, Rosenfeld J, Shann F, Ditchfield M, Lewis E, et al: A randomized trial of very early decompressive craniectomy in children with traumatic brain injury and sustained intracranial hypertension. Childs Nerv Syst 2001;17:154–162.
27.
Adamo MA, Drazin D, Waldman JB: Decompressive craniectomy and postoperative complication management in infants and toddlers with severe traumatic brain injuries. J Neurosurg Pediatr 2009;3:334–339.
28.
Brain Trauma Foundation: Management and Prognosis of Severe Traumatic Brain Injury. New York, Brain Trauma Foundation, 2003.
29.
Berger MS, Pitts LH, Lovely M, Edwards MS, Bartkowski HM: Outcome from severe head injury in children and adolescents. J Neurosurg 1985;62:194–199.
30.
Adelson PD, Bratton SL, Carney NA, Chesnut RM, du Coudray HE, Goldstein B, et al: Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents. 6. Threshold for treatment of intracranial hypertension. Pediatr Crit Care Med 2003;4(suppl):S25–S27.
31.
Pfenninger J, Kaiser G, Lutschg J, Sutter M: Treatment and outcome of the severely head injured child. Intensive Care Med 1983;9:13–16.
32.
Doppenberg EM, Choi SC, Bullock R: Clinical trials in traumatic brain injury: what can we learn from previous studies? Ann NY Acad Sci 1997;825:305–327.
33.
Maas AI, Marmarou A, Murray GD, Steyerberg EW: Clinical trials in traumatic brain injury: current problems and future solutions. Acta Neurochir Suppl 2004;89:113–118.
34.
Aarabi B, Hesdoffer DC, Ahn ES, Aresco C, Scalea TM, Eisenberg HM: Outcome following decompressive craniectomy for malignant swelling following brain injury. J Neurosurg 2006;104:469–479.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.