Background: Spinal cord injury without radiographic abnormality (SCIWORA) represents a traumatic myelopathy, either transient or permanent, that is not associated with visible vertebral fractures or ligamentous abnormalities on plain radiographs or CT. MRI has become essential in the diagnosis and evaluation of trauma patients and in predicting the long-term neurological outcome. Methods: The medical charts of 578 children with vertebral trauma at the Children’s Hospital of Eastern Ontario and the Hospital for Sick Children were retrospectively reviewed. Results: Forty-five patients were identified as having traumatic myelopathy. Three of these patients had SCIWORA. Two sustained thoracic spinal cord injuries as a result of motor vehicle accidents and permanent neurological deficits. The third was involved in a sports-related injury and sustained a cervical spine injury that improved in 48 h. Conclusions: SCIWORA is uncommon. The serious neurological sequelae that can result from a missed diagnosis merit more attention in identifying a spinal lesion in children with traumatic myelopathy. MRI has played a valuable role in this respect and may be even more predictive of outcome than the presenting neurological findings. The SCIWORA acronym can be modified to SCIWONA (spinal cord injury without neuroimaging abnormality) in order to highlight the importance of MRI in the prognosis.

1.
Pang D, Wilberger JE Jr: Spinal cord injury without radiographic abnormalities in children. J Neurosurg 1982;57:114–129.
2.
Babcock JL: Spinal injuries in children. Pediatr Clin North Am 1975;22:487–500.
3.
Kewalramani LS, Kraus JF, Sterling HM: Acute spinal-cord lesions in a pediatric population: epidemiological and clinical features. Paraplegia 1980;18:206–219.
4.
Pang D: Spinal cord injury without radiographic abnormality in children, 2 decades later. Neurosurgery 2004;55:1325–1343.
5.
Pollack IF, Pang D, Sclabassi R: Recurrent spinal cord injury without radiographic abnormalities in children. J Neurosurg 1988;69:177–182.
6.
Cirak B, Ziegfeld S, Knight VM, Chang D, Avellino AM, Paidas CN: Spinal injuries in children. J Pediatr Surg 2004;39:607–612.
7.
Hendey GW, Wolfson AB, Mower WR, Hoffman JR: Spinal cord injury without radiographic abnormality: results of the National Emergency X-Radiography Utilization Study in blunt cervical trauma. J Trauma 2002;53:1–4.
8.
Yucesoy K, Yuksel KZ: SCIWORA in MRI era. Clin Neurol Neurosurg 2008;110:429–433.
9.
Dickman CA, Zabramski JM, Hadley MN, Rekate HL, Sonntag VK: Pediatric spinal cord injury without radiographic abnormalities: report of 26 cases and review of the literature. J Spinal Disord 1991;4:296–305.
10.
Carreon LY, Glassman SD, Campbell MJ: Pediatric spine fractures: a review of 137 hospital admissions. J Spinal Disord Tech 2004;17:477–482.
11.
Turgut M, Akpinar G, Akalan N, Ozcan OE: Spinal injuries in the pediatric age group: a review of 82 cases of spinal cord and vertebral column injuries. Eur Spine J 1996;5:148–152.
12.
Hamilton MG, Myles ST: Pediatric spinal injury: review of 174 hospital admissions. J Neurosurg 1992;77:700–704.
13.
Osenbach RK, Menezes AH: Spinal cord injury without radiographic abnormality in children. Pediatr Neurosci 1989;15:168–174, discussion 175.
14.
Osenbach RK, Menezes AH: Pediatric spinal cord and vertebral column injury. Neurosurgery 1992;30:385–390.
15.
Kriss VM, Kriss TC: SCIWORA (spinal cord injury without radiographic abnormality) in infants and children. Clin Pediatr (Phila) 1996;35:119–124.
16.
Ruge JR, Sinson GP, McLone DG, Cerullo LJ: Pediatric spinal injury: the very young. J Neurosurg 1988;68:25–30.
17.
Liao CC, Lui TN, Chen LR, Chuang CC, Huang YC: Spinal cord injury without radiological abnormality in preschool-aged children: correlation of magnetic resonance imaging findings with neurological outcomes. J Neurosurg 2005;103:17–23.
18.
Marinier M, Rodts MF, Connolly M: Spinal cord injury without radiographic abnormality (SCIWORA). Orthop Nurs 1997;16:57–63, quiz 64–65.
19.
Eleraky MA, Theodore N, Adams M, Rekate HL, Sonntag VK: Pediatric cervical spine injuries: report of 102 cases and review of the literature. J Neurosurg 2000;92:12–17.
20.
Akbarnia BA: Pediatric spine fractures. Orthop Clin North Am 1999;30:521–536, x.
21.
Pang D, Pollack IF: Spinal cord injury without radiographic abnormality in children: the SCIWORA syndrome. J Trauma 1989;29:654–664.
22.
Brown RL, Brunn MA, Garcia VF: Cervical spine injuries in children: a review of 103 patients treated consecutively at a level 1 pediatric trauma center. J Pediatr Surg 2001;36:1107–1114.
23.
Baker C, Kadish H, Schunk JE: Evaluation of pediatric cervical spine injuries. Am J Emerg Med 1999;17:230–234.
24.
Ergun A, Oder W: Pediatric care report of spinal cord injury without radiographic abnormality (SCIWORA): case report and literature review. Spinal Cord 2003;41:249–253.
25.
Hadley MN, Zabramski JM, Browner CM, Rekate H, Sonntag VK: Pediatric spinal trauma: review of 122 cases of spinal cord and vertebral column injuries. J Neurosurg 1988;68:18–24.
26.
Tewari MK, Gifti DS, Singh P, Khosla VK, Mathuriya SN, Gupta SK, Pathak A: Diagnosis and prognostication of adult spinal cord injury without radiographic abnormality using magnetic resonance imaging: analysis of 40 patients. Surg Neurol 2005;63:204–209, discussion 209.
27.
Anderson JM, Schutt AH: Spinal injury in children: a review of 156 cases seen from 1950 through 1978. Mayo Clin Proc 1980;55:499–504.
28.
Baker DH, Berdon WE: Special trauma problems in children. Radiol Clin North Am 1966;4:289–305.
29.
Braakman R, Penning L: The hyperflexion sprain of the cervical spine. Radiol Clin Biol 1968;37:309–320.
30.
Cattell HS, Filtzer DL: Pseudosubluxation and other normal variations in the cervical spine in children: a study of one hundred and sixty children. J Bone Joint Surg Am 1965;47:1295–1309.
31.
Wilberger JE, Abla A, Maroon JC: Burning hands syndrome revisited. Neurosurgery 1986;19:1038–1040.
32.
Garton HJ, Hammer MR: Detection of pediatric cervical spine injury. Neurosurgery 2008;62:700–708, discussion 700–708.
33.
Gupta SK, Rajeev K, Khosla VK, Sharma BS, Paramjit, Mathuriya SN, Pathak A, Tewari MK, Kumar A: Spinal cord injury without radiographic abnormality in adults. Spinal Cord 1999;37:726–729.
34.
Benzel EC, Hart BL, Ball PA, Baldwin NG, Orrison WW, Espinosa MC: Magnetic resonance imaging for the evaluation of patients with occult cervical spine injury. J Neurosurg 1996;85:824–829.
35.
Selden NR, Quint DJ, Patel N, D’Arcy HS, Papadopoulos SM: Emergency magnetic resonance imaging of cervical spinal cord injuries: clinical correlation and prognosis. Neurosurgery 1999;44:785–92, discussion 792–793.
36.
Flanders AE, Spettell CM, Friedman DP, Marino RJ, Herbison GJ: The relationship between the functional abilities of patients with cervical spinal cord injury and the severity of damage revealed by MR imaging. AJNR Am J Neuroradiol 1999;20:926–934.
37.
Matsumura A, Meguro K, Tsurushima H, Kikuchi Y, Wada M, Nakata Y: Magnetic resonance imaging of spinal cord injury without radiologic abnormality. Surg Neurol 1990;33:281–283.
38.
Bosch PP, Vogt MT, Ward WT: Pediatric spinal cord injury without radiographic abnormality (SCIWORA): the absence of occult instability and lack of indication for bracing. Spine (Phila Pa 1976) 2002;27:2788–2800.
39.
Grabb PA, Pang D: Magnetic resonance imaging in the evaluation of spinal cord injury without radiographic abnormality in children. Neurosurgery 1994;35:406–414, discussion 414.
40.
Wenger M, Adam PJ, Alarcon F, Markwalder TM: Traumatic cervical instability associated with cord oedema and temporary quadriparesis. Spinal Cord 2003;41:521–526.
41.
Flanders AE, Schaefer DM, Doan HT, Mishkin MM, Gonzalez CF, Northrup BE: Acute cervical spine trauma: correlation of MR imaging findings with degree of neurologic deficit. Radiology 1990;177:25–33.
42.
Dare AO, Dias MS, Li V: Magnetic resonance imaging correlation in pediatric spinal cord injury without radiographic abnormality. J Neurosurg 2002;97:33–39.
43.
Martin BW, Dykes E, Lecky FE: Patterns and risks in spinal trauma. Arch Dis Child 2004;89:860–865.
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