Angiocentric glioma, a rare brain neoplasm with features of ependymal differentiation, has only recently been recognized as a distinct clinicopathological entity. To date, all reported cases have involved tumors in the cerebral hemispheres, and the majority have presented with seizures. The authors report the case of a 5-year-old girl who presented with several cranial neuropathies and mild gait disturbance. An exophytic neoplasm arising from the posterior midbrain and causing obstructive hydrocephalus was identified, and surgical resection revealed a neoplasm with features of angiocentric glioma.

Keywords:
Angiocentric glioma, Pediatric, Astrocytoma, Ependymoma, Brain tumor
1.
Wang M, Tihan T, Rojiani A, Bodhireddy S, Burger PC: Angiocentric bipolar astrocytoma: a distinctive infiltrating. J Neuropathol Exp Neurol 2002;61:475.
2.
Wang M, Tihan T, Rojiani AM, Bodhireddy SR, Prayson RA, Iacuone JJ, Alles AJ, Donahue DJ, Hessler RB, Kim JH, Haas M, Rosenblum MK, Burger PC: Monomorphous angiocentric glioma: a distinctive epileptogenic neoplasm with features of infiltrating astrocytoma and ependymoma. J Neuropathol Exp Neurol 2005;64:875–881.
3.
Lellouch-Tubiana A, Boddaert N, Bourgeois M, Fohlen M, Jouvet A, Delalande O, Seidenwurm D, Brunelle F, Sainte-Rose C: Angiocentric neuroepithelial tumor (ANET): a new epilepsy-related clinicopathological entity with distinctive MRI. Brain Pathol 2005;15:281–286.
4.
Preusser M, Hoischen A, Novak K, Czech T, Prayer D, Hainfellner JA, Baumgartner C, Woermann FG, Tuxhorn IE, Pannek HW, Bergmann M, Radlwimmer B, Villagran R, Weber RG, Hans VH: Angiocentric glioma: report of clinico-pathologic and genetic findings in 8 cases. Am J Surg Pathol 2007;31:1709–1718.
5.
Louis DN, Ohgaki H, Weistler OD, Cavenee WK: WHO Classification of Tumours of the Central Nervous System, ed 4. Lyon, IARC, 2007.
6.
Shakur SF, McGirt MJ, Johnson MW, Burger PC, Ahn E, Carson BS, Jallo GI: Angiocentric glioma: a case series. J Neurosurg Pediatr 2009;3:197–202.
7.
Rosenblum MK: Monomorphous angiocentric glioma/angiocentric neuroepithelial tumor; in McLendon RE, Rosenblum MK, Bigner DD (eds): Russell and Rubinstein’s Pathology of Tumors of the Nervous System, ed 7. London, Hodder-Arnold, 2006, pp 223–228.
8.
May PL, Blaser SI, Hoffman HJ, Humphreys RP, Harwood-Nash DC: Benign intrinsic tectal ‘tumors’ in children. J Neurosurg 1991;74:867–871.
9.
Pollack IF, Pang D, Albright AL: The long-term outcome in children with late-onset aqueductal stenosis resulting from benign intrinsic tectal tumors. J Neurosurg 1994;80:681–688.
10.
Robertson PL, Muraszko KM, Brunberg JA, Axtell RA, Dauser RC, Turrisi AT: Pediatric midbrain tumors: a benign subgroup of brainstem gliomas. Pediatr Neurosurg 1995;22:65–73.
© 2010 S. Karger AG, Basel
2010
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.