Abstract
Paragangliomas are tumors arising from extra-adrenal paraganglia and account for 0.3% of all neoplasms. The carotid body and temporal bone are the most frequent sites of paraganglioma, though it has been reported to occur in almost every part of the body. Spinal paragangliomas are uncommon and mainly take the form of intradural compression of the cauda equina or thoracic cord. Extradural paragangliomas are still rare; only few cases involving the dorsolumbar spine have been reported. We are reporting an interesting case of a dumbbell-shaped primary extradural paraganglioma of the cervical spine in an 8-year-old boy that presented with progressively increasing spastic quadriparesis.
References
1.
Sampson JH, Wilkins RH: Paragangliomas of the carotid body and temporal bone; in Wilkins RH, Rengachary SS (eds): Neurosurgery. New York, McGraw-Hill, 1996, vol 2, pp 1559–1571.
2.
Pearse A: The cytochemistry and ultrastructure of polypeptide hormone producing cells of the APUD series and the embryonic, physiologic and pathologic implications of the concept. J Histochem Cytochem 1969;17:303–313.
3.
Rengachary SS, Duke DA: Paragangliomas of the cauda equina; in Wilkins RH, Rengachary SS (eds): Neurosurgery. New York, McGraw-Hill, 1996, vol 2, pp 1783–1789.
4.
Rao AB, Koeller KK, Adair CF: Paragangliomas of the head and neck. Radiographics 1999;19:1605–1632.
5.
Gelabert-González M: Paragangliomas of the lumbar region – report of two cases and review of the literature. J Neurosurg Spine 2005;2:354–365.
6.
Herman M, Pozzi-Mucelli R, Skrap M: Paraganglioma of the cauda equina: case report and review of the MRI features. Acta Univ Palacki Olomuc Fac Med 1998,141:27–30.
7.
Pigott TJ, Lowe JS, Morrell K, Kerslake RW: Paraganglioma of the cauda equina: report of three cases. J Neurosurg 1990;73:455–458.
8.
Singh P, Singh AP, Rajaram T, Sabhikhi AK: Paraganglioma of cauda equina: a case report. Neurol India 2000;48:290–292.
9.
Tanriover N, Akar Z, Kafadar A, Oz B, Kuday C: Cauda equina paraganglioma, with a previous hemorrhage. J Neurol Sci 2000;17:1.
10.
Houten JK, Babu RP, Miller DC: Thoracic paraganglioma presenting with spinal cord compression and metastases. J Spinal Disord Tech 2002;15:319–323.
11.
Fitzgerald LF, Cech DA, Goodman JC: Paraganglioma of the thoracic spinal cord. Clin Neurol Neurosurg 1996;98:183–5.
12.
Cybulski GR, Nijensohn E, Brody BA, Meyer PR Jr, Cohen B: Spinal cord compression from a thoracic paraganglioma: case report. Neurosurgery 1991;28:306–9.
13.
Constantini S, Soffer S, Siegal T, Shalit MN: Paraganglioma of the thoracic spine with cerebrospinal fluid metastases. Spine 1989;14:643–645.
14.
Shin JY, Lee SM, Hwang MY, Sohn CH, Suh SJ: MR Findings of the spinal paraganglioma: report of 3 cases. J Korean Med Sci 2001;16:522–526.
15.
Blades DA, Hardy RW, Cohen M: Cervical paraganglioma with subsequent intracranial and intraspinal metastases: case report. J Neurosurg 1991;75:320–323.
16.
Moran CA, Rush W, Mena H: Primary spinal paragangliomas: a clinicopathological and immunohistochemical study of 30 cases. Histopathology 1997;31:167–173.
17.
Lei P, Wu Y, Li ZY, Wang Y: Microsurgical resection of tumors lateroventral and ventral to the high cervical spinal cord. Chin Med J 2005;118:828–832.
18.
Gerszten P, Ozhasoglu C, Burton SA, Kalnicki S, Welch WC: Feasibility of frameless single-fraction stereotactic radiosurgery for spinal lesions. Neurosurg Focus 2002;13:e2.
19.
Lazaro B, Klemz M, Flores MS, Landeiro JA: Malignant paraganglioma with vertebral metastasis: case report. Arq Neuropsiquiatr 2003;61:463–467.
20.
Osborn RE, Mojtahedi S: Paraganglioma metastatic to the cervical spine. Comput Radiol 1986;10:167–170.
21.
Yamaguchi S, Hida K, Nakamura N, Seki T, Iwasaki Y: Multiple vertebral metastases from malignant cardiac pheochromocytoma – case report. Neurol Med Chir (Tokyo) 2003;43:352–355.
22.
Glassock MEI: The history of glomus tumors: a personal perspective. Laryngoscope 1993;103:3–6.
23.
Valavnis A: Preoperative embolization of head and neck: indications, patient selection, goals and precautions. Am J Neuroradiol 1986;7:943–952.
24.
Davidson J, Gullane P: Glomuus vagale tumours. Otolaryngol Head Neck Surg 1988;99:66–70.
25.
Anand VK, Leonetti JP, al Mefty O: Neurovascular consideration in surgery of glomours tumours with intracranial extensions. Laryngoscope 1993;103:772–728.
26.
Bishop GB Jr, Urist MM, Eel Gammal T, Peters GE, Maddox WA: Paragangliomas of the neck. Arch Surg 1992;127:1441–1445.
© 2007 S. Karger AG, Basel
2006
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