Focal intracranial infections due to Salmonella are rare. So far, around 80 cases have been reported in the world literature. The authors present their experience of 6 cases of intracranial Salmonella infections, mainly subdural empyema in 5 and effusion in 1. In 1 case, subdural empyema was bilateral, and in another case, there was an associated brain abscess. Positive blood cultures and positive Widal tests were noticed in 2 patients each. Early diagnosis and prompt evacuation of subdural collections and brain abscess and antibiotic therapy lead to satisfactory results. This study suggests that a high index of suspicion, early diagnosis and quick evacuation lead to success; this point is highlighted with the help of a review of the literature.

1.
Hanel RA, Araujo JC, Antoniuk A, de Silva Ditzel LF, Flenik Martins LT, Linhares MN: Multiple brain abscess caused by Salmonella typhi: Case report. Surg Neurol 2000;53:86–90.
2.
Lee WS, Puthucheary SD, Omar A: Salmonella meningitis and its complications in infants. J Paediatr Child Health 1999;35:379–382.
3.
Lerner PI, Golden PF, Jane JA: Salmonella-infected subdural hematoma. Pediatrics 1972;49:127–128.
4.
Mahapatra AK, Bhatia R: Salmonella intracerebral and subdural abscess – report of two cases. Postgrad Med J 1987;63:373–375.
5.
Rodriguez RE, Valero V, Watanakunakorn C: Salmonella focal intracranial infections: Review of the world literature (1884–1984) and report of an unusual case. Rev Infect Dis 1986;8:31–41.
6.
Sarria JC, Vidal AM, Kimbrough RC: Salmonella enteritidis brain abscess: Case report and review. Clin Neurol Neurosurg 2000;102:236–239.
7.
Yen MH, Huang YC, Chou ML: Non-typhoid Salmonella subdural empyema in children: Report of two cases: J Microbiol Immunol Infect 1999;32:289–291.
8.
Buchanan N, Borger H, Van Hoog Straten RCJ: Subdural empyema caused by Salmonella typhimurium. S. Afr Med J 1973;47:1345–1346.
9.
Dunn DW, McAllister J, Craft JC: Brain abscess and empyema caused by Salmonella. Pediatr Infect Dis 1984;3:54–57.
10.
Kaufman DM, Miller MH, Steigbigel NH: Subdural empyema: Analysis of 17 recent cases and review of the literature. Medicine (Baltimore) 1975;54:485–498.
11.
Chandy MJ: Subdural Salmonella empyema in an adult (letter). Neurol India 2000;48:297.
12.
Ferris J, Peres-Aytes A, Bazan J: Subdural collection infected by Salmonella. Rev Esp Pediatr 1980;36:303–304.
13.
Gairi Tahall JM, Cracia-Tornel Florensa S, Costa Clara JM, Rogi Quilis M, Campos Marques J: Empyema subdural secundario a meningitis por ‘Salmonella’. Ann Esp Pediatr 1983;19:74–76.
14.
Jain KC, Mahapatra AK: Subdural empyema due to salmonella infection. Pediatr Neurosurg 1998;28:89–90.
15.
Mussini C, Trenti F, Manicardi G, Mongiardo N, Codeluppi M, D’Andrea L, Guaraldi G, Squadrini F, De Rienzo B: Non-typhoid Salmonella subdural empyema in a patient with AIDS. Scand J Infect Dis 1995;27:1973–1974.
16.
Okudera H, Toba Y, Kyoshima K: Bilateral subdural empyema due to Salmonella enteretidis in an infant. Childs Nerv Syst 1989;5:45–46.
17.
Hou JW, Teng RC, Lee CY: Salmonella meningitis complicated with subdural empyema, brain abscess and purpura fulminans. Report of one case. Acta Pediatr Sin 1989;30:408–413.
18.
Aliaga L, Mediavilla JD, Lopez de la Osa A, Lopez-Gomez M, de Cueto M, Miranda C: Nontyphoidal salmonella intracranial infections in HIV-infected patients. Clin Infect Dis 1997;25:1118–1120.
19.
Gonzalez Mata A, Manjarrez-Gutierrez G, Munoz Hernadez O: Empyema subdural por Salmonella typhimurium: Analisis de un caso. Bol Med Hosp Infant Mex 1979;36:833–837.
20.
Odeku EL, Ransome-Kuti O, Elam HP: Aneurysm of the great vein of Galen complicated by chronic subdural abscess. West Afr Med J Niger Pract 1967;16:109–113.
21.
Utian HL: Salmonella Dublin meningitis: Report of a case complicated by a right subdural effusion. S Afr Med J 1957;31:577–579.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.