We present an overview of the clinical outcome and surgical treatment of 34 pediatric spinal tumors, carried out in our center from 1981 to 1999. Follow-ups were available for 25.5 months on average. Clinical history, signs, surgical approach, outcome and radiological reports were obtained by review of the patients’ charts. These pediatric tumors formed a very heterogeneous group, with a predominance of neurinomas and neurofibromas in older children and neuroblastomas or primitive neuroectodermal tumors in younger ones. Ependymomas and astrocytomas were the most frequent intramedullary tumors. Extradural tumors included tumors such as aneurysmal bone cysts, Ewing’s sarcoma, histiocytomas, chordomas and an angiofibroma. Following decompression of the spinal cord, the neurological status improved with good functional recovery in 23 children and had deteriorated at follow-up in 5 children. Relapse occurred in 12 cases, including histiocytomas, chordomas, medulloblastoma and tumors associated with genetic disorders. Eighteen children underwent a combined treatment with chemotherapy and/or radiotherapy. The spectrum of pathology is wide and requires multidisciplinary treatment.

1.
O’Sullivan C, Jenkin RD, Doherty MA, Hoffman HJ, Greenberg ML: Spinal cord tumors in children: Long-term results of combined surgical and radiation treatment. J Neurosurg 1994;81:507–512.
2.
Nadkarni TD, Rekate HL: Pediatric intramedullary spinal cord tumors. Childs Nerv Syst 1999;15:17–28.
3.
Raffel C, Neave VCD, Lavine S, McComb JG: Treatment of spinal cord compression by epidural malignancy in childhood. Neurosurgery 1991;28:349–352.
4.
Cheshire DJE: A classification of the functional end-results of injury to the cervical cord. Paraplegia 1970;8:70–73.
5.
Hoover M, Bowman LC, Crawford SE, Stack C, Donaldson JS, Grayhack JJ, Tomita T, Cohn SL: Long-term outcome of patients with intraspinal neuroblastoma. Med Pediatr Oncol 1999;32:353–359.
6.
Albright AL: Pediatric intramedullary spinal cord tumors. Childs Nerv Syst 1999;15:436–437.
7.
Beer SJ, Menezes AH: Primary tumors of the spine in children. Spine 1997;22:649–659.
8.
Houten JK, Weiner HL: Pediatric intramedullary spinal cord tumors: Special considerations. J Neurooncol 2000;47:225–230.
9.
Innocenzi G, Raco A, Cantore G, Raimondi J: Intramedullary astrocytomas and ependymomas in the pediatric age group: A retrospective study. Childs Nerv Syst 1996;12:776–780.
10.
Lunardi P, Licastro P, Missori P, Ferrante L, Fortuna A: Management of intramedullary tumours in children. Acta Neurochir (Wien) 1993;120:59–65.
11.
Merchant TE, Kiehna EN, Thompson SJ, Heideman R, Sanford RA, Kun LE: Pediatric low-grade and ependymal spinal cord tumors. Pediatr Neurosurg 2000;32:30–36.
12.
Raimondi AJ: Pediatric Neurosurgery. New York, Springer, 1987, pp 339–348.
13.
Rossitch E, Zeidman SM, Burger PC, Curnes JT, Harsh C, Anscher M, Oakes WJ: Clinical and pathological analysis of spinal cord astrocytomas in children. Neurosurgery 1990;27:193–196.
14.
Sinha AK, Seki JT, Moreau G, Ventureyra E, Letts RM: The management of spinal metastasis in children. Can J Surg 1997;40:218–226.
15.
De Kleuver M, van der Heul RO, Veraart BE: Aneurysmal bone cyst of the spine. J Pediatr Orthop B 1988;7:286–292.
16.
Ozaki T, Halm H, Hillmann A, Blasius S, Winkelmann W: Aneurysmal bone cysts of the spine. Arch Orthop Trauma Surg 1999;119:159–162.
17.
Stella G, De Sanctis N, Boero S, Rondinella F: Benign tumors of the pediatric spine: Statistical notes. Chir Organi Mov 1998;83:15–21.
18.
Levy WJ, Latchaw J, Hahn JF, Sawhny B, Bay J, Dohn DF: Spinal neurofibromas: A report of 66 cases and a comparison with meningiomas. Neurosurgery 1986;18:331–334.
19.
Lot G, George B: Cervical neuromas with extradural components: Surgical management in a series of 57 patients. Neurosurgery 1997;41:813–822.
20.
El-Mahdy W, Kane PJ, Powell MP, Crockard HA: Spinal intradural tumours: Part I – Extramedullary. Br J Neurosurg 1999;13:550–557.
21.
Klekamp J, Samii M: Spinal chordomas – results of treatment over a 17-year period. Acta Neurochir (Wien) 1996;138:514–519.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.