The authors describe an 11-year-old girl with duplication of a pituitary gland and hypertelorism. Of the 14 cases described to date, only 2 others have lacked associated major facial or oral anomalies. Two separate glands, respective stalks and hypothalamic enlargement were incidentally found on MR imaging performed to evaluate the patient’s complaint of anosmia. A tortuous fusiform dilatation of one pericallosal artery was also discovered. A review of hypophyseal embryogenesis is presented. It is now evident that duplication of the pituitary can occur without other major dysmorphias. This may infer that notochord/prochordal plate deficits are not a prerequisite for hypophyseal duplication.

1.
Bainborough AR, Hase S: Double hypophysis. Can Med Assoc J 1958;79:912–913.
2.
Ryals BD, Brown DC, Levin SW: Duplication of the pituitary gland as shown by MR. AJNR 1993;14:137–139.
3.
Ahlfeld F: Die Missbildungen des Menschen. Leipzig, Grunow, 1880, pp 72–95.
4.
Morton WRM: Duplication of the pituitary and stomatodeal structures in a 38-week male infant. Arch Dis Child 1957;32:135–141.
5.
Roessmann U: Duplication of the pituitary gland and spinal cord. Arch Pathol Lab Med 1985;109:518–520.
6.
Kollias SS, Ball WS, Prenger EC: Review of the embryologic development of the pituitary gland and report of a case of hypophyseal duplication detected by MRI. Neuroradiology 1995;37:3–12.
7.
Bale PM, Reye RDK: Epignathus, double pituitary, and agenesis of corpus callosum. J Pathol 1976;120:161–164.
8.
Hori A: A brain with two hypophyses in median cleft face syndrome. Acta Neuropathol 1983;59:150–154.
9.
Bagherian V, Graham M, Gerson LP, Armstrong DL: Double pituitary glands with partial duplication of facial and fore brain structures with hydrocephalus. Comput Radiol 1984;8:203–210.
10.
Tagliavini F, Pilleri G: Mammillo-hypophyseal duplication (diplo-mammillo-hypophysis). Acta Neuropathol (Berl) 1986;69:38–44.
11.
Il’ina EG, Laziuk GI: A new case of the ‘double hypophysis-multiple congenital developmental defects’ complex. Tsitol Genet 1989;23:45–46.
12.
Shah S, Pereira JK, Becker CJ, Roubal SE: Duplication of pituitary gland. J Comput Assist Tomogr 1997;21:459–461.
13.
Muller F, O’Rahilly R: The development of the human brain from a closed neural tube at stage 13. Anat Embryol 1988;177:203–224.
14.
Muller F, O’Rahilly R: The first appearance of the neural tube and optic primordium in the human embryo at stage 10. Anat Embryol 1985;172:157–169.
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