Background: On clinical grounds, arachnoid cysts are usually associated with neurological dysfunction. There is little information concerning their involvement in endocrinological disorders. Patients: The experience in 6 children (birth to 12 years) with hypothalamic-pituitary disturbances secondary to the presence of intracranial arachnoid cysts is reported and the literature is reviewed. Results: Three of our children were diagnosed with isolated hormone abnormalities (2 children with precocious puberty and 1 child with growth hormone, GH deficiency). One child presented the unusual combination of GH deficiency and precocious puberty. The remaining 2 children developed panhypopituitarism associated with diabetes insipidus. Conclusion: Arachnoid cysts may cause a wide spectrum of endocrinological disorders. Periodical and complete follow-up of every patient is recommended.

Robinson RG: Congenital cysts of the brain. Arachnoid malformation. Progr Neurol Surg 1971;4:133–174.
Grumbach MM, Styne DM: Puberty: Ontogeny, neuroendocrinology, physiology, and disorders; in Wilson JD, Foster DW, Kronenberg HM, Larsen PR (eds): Williams Textbook of Endocrinology. Philadelphia, Saunders, 1998, pp 1509–1626.
Reinken L, van OG: Longitudinale Körperentwicklung gesunder Kinder von 0 bis 18 Jahren. Körperlänge/-höhe, Körpergewicht und Wachstumsgeschwindigkeit. Klin Pädiatr 1992;204:129–133.
Oberbauer RW, Haase J, Pucher R: Arachnoid cysts in children: A European co-operative study. Childs Nerv Syst 1992;8:281–286.
Harsh GR, Edwards MS, Wilson CB: Intracranial arachnoid cysts in children. J Neurosurg 1986;64:835–842.
Brauner R, Pierre KA, Nemedy SE, Rappaport R, Hirsch JF: Pubertés précocés par kyste arachnoidien suprasellaire. Analyse de 6 observations. Arch Fr Pediatr 1987;44:489–493.
Clark SJ, Van DC, Conte FA, Grumbach MM, Berger MS, Edwards MS: Reversible true precocious puberty secondary to a congenital arachnoid cyst (letter). Am J Dis Child 1988;142:255–256.
Flicker DJ: Pubertas praecox in an female infant caused by ventricular cyst. Report of a case. J Nerv Ment Dis 1943;98:42–47.
Kivelä T, Pelkonen R, Oja M, Heiskanen O: Diabetes insipidus and blindness caused by a suprasellar tumor: Pieter Pauw’s observations from the 16th century. JAMA 1998;279:48–50.
Mori K: Precocious puberty with fits of laughter and a large cystic mass in the third ventricle. Case report. Nippon Geka Hokan 1969;38:800–804.
Okamoto K, Nakasu Y, Sato M, Handa J: Isosexual precocious puberty associated with multilocular arachnoid cysts at the cranial base. Report of a case. Acta Neurochir Wien 1981;57:87–93.
Segall HD, Hassan G, Ling SM, Carton C: Suprasellar cysts associated with isosexual precocious puberty. Radiology 1974;111:607–616.
Sweasey TA, Venes JL, Hood TW, Randall JB: Stereotactic decompression of a prepontine arachnoid cyst with resolution of precocious puberty. Pediatr Neurosci 1989;15:44–47.
Turgut M, Ozcan OE: Suprasellar arachnoid cyst as a cause of precocious puberty and bobble-head doll phenomenon (letter). Eur J Pediatr 1992;151:76.
Fernandes YB, Guerra JG, Lemos SH, Matias MT, Damasceno BP, Hamamoto O, Marconi JA, Honorato DC, Marins JL: Associacao singular de sindrome de Kallmann e cisto aracnoide da fossa media. Relato de caso. Arq Neuropsiquiatr 1995;53:662–666.
Ferrari C, Crosignani PG: Hypothalamic disease presenting as amenorrhoea: Value of computed tomography. Br J Obstet Gynaecol 1985;92:1251–1257.
Rischbieth RH: Hypopituitarism with arachnoid cyst. Clin Exp Neurol 1983;19:87–93.
Longas AF, Mayayo E, Labarta JI: Congenital growth hormone deficiency arising from central cranial malformations: Experience in KIGS; in Ranke M, Wilton P (eds): KIGS. Heidelberg, Barth Verlag, 1999.
DeMorsier G: Etudes sur les dysraphies cranio-encéphaliques: Agenesis du septum lucidum avec malformation des traques optiques: La dysplasie septo-optique. Schweiz Arch Neurol Neurochir Psychiatr 1956;94:267–292.
Hoyt WF, Kaplan SL, Grumbach MM, Glaser JS: Septo-optic dysplasia and pituitary dwarfism. Lancet 1970;i:893–894.
Zeki SM, Hollman AS, Dutton GN: Neuroradiological features of patients with optic nerve hypoplasia. J Pediatr Ophthalmol Strabismus 1992;29:107–112.
Swett HA, Nixon GW: Agenesis of the corpus callosum with interhemispheric cyst. Radiology 1975;114:641–645.
Zingesser L, Gonatas N, Levy A, Wisoff H: Agenesis of the corpus callosum associated with an inter-hemispheric arachnoid cyst. Br J Radiol 1964;37:161–166.
Ichiyama T, Hayashi T, Nishikawa M, Furukawa S: Optic nerve hypoplasia with hypopituitarism and an arachnoid cyst. Brain Dev 1996;18:234–235.
Bercovici JP, Besson G, Caroff J: Puberté précoce, kyste arachnoïdien du 3e ventricule et acétate de cyproterone. Ann Endocrinol Paris 1976;37:467–468.
Kumar A, Chaudhary D, Gupta SK: Isosexual precocious puberty in a boy with meningomyelocele and cerebral arachnoid cyst. Indian Pediatr 1995;32:101–103.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.