...Stephen J. Kling; Cambria A. Judd; Keith B. Warner; George M. Rodgers ADAMTS13, the von Willebrand factor-cleaving protease, is constitutively produced by endothelial cells. The aim was to quantify ADAMTS13 production in proliferating and nonproliferating human umbilical vein endothelial cells...

... of highly substituted, high-molecular-weight starch often leads to iatrogenic von Willebrand syndrome (vWS) with hemorrhagic complications. In patients with cerebral circulatory disturbances we carried out hemodilution therapy during 9-10 days, infusing HES 200/0.62. A von Willebrand factor (vWF) multimeric...

... with intermittent claudication. One hundred and thirty men at high cardiovascular risk and 51 men at low risk were examined. The subjects (high- and low-risk) with moderate/large plaque (n = 96) had higher fibrinogen, thrombin/antithrombin complex and von Willebrand factor, compared to subjects with small/no plaque...

..., soluble P-selectin or von Willebrand factor. In venous samples, von Willebrand factor was lower in serum than in plasma (p < 0.0001). Levels of the tissue plasminogen activator/plasminogen activator inhibitor-1 (tPA/PAI-1) complex were markedly higher in arterial blood than in venous blood (p = 0.004...

... and immunoblotting conditions employed to explore human plasmatic and platelet von Willebrand factor (vWF) and human platelet GP Ilb-IHa using IgYs. These two proteins are involved in primary hemostasis and their absence or abnormality is responsible for hereditary bleeding disorders. The methods were applied...

...Pier Mannuccio Mannucci Therapeutic plasma concentrates containing von Willebrand factor (vWF) lack the largest, most hemostatically active multimers. In order to evaluate whether this abnormality results from proteolysis during manufacturing, we have analyzed the subunit structure of vWF in 21...

... factor synthesized by endothelial cells is the von Willebrand factor (vWF). vWF is a large plasma glycoprotein which promotes the adhesion of platelets to the vessel wall after a vascular injury. vWF is initially synthesized as a pre-pro-polypeptide. During its transport to the outside of the cell...

...Jan Hendrik Reinders; Philip G. de Groot; Jan J. Sixma; Jan A. van Mourik Endothelial cells synthesize and store von Willebrand factor. We have studied the storage and secretion of von Willebrand factor in cultured human umbilical vein endothelial cells. In particular, we were interested...

... a fall in single platelet count of up to 85% due to aggregation. The extent of aggregation was directly proportional to the amount (0.007–0.1 U/ml test aliquot) of residual von Willebrand factor antigen (vWl·Ag) in the preparations. A monoclonal antibody to vWl·Ag inhibited the aggregation. We believe...

...Koji Taira; Hidekazu Kamitsuji; Chikako Okajima; Yoshihiro Fujimura To elucidate the mechanism of enhanced ristocetin-induced platelet aggregation (RIPA) in steroid-responsive nephrotic syndrome (SRNS), plasma levels of von Willebrand factor antigen (vWF:Ag) and ristocetin cofactor (RCof) were...

...M.G. Mazzucconi; A. Ferrari; S. Solinas; A. Vitale; A. Chistolini; A.B. Federici; F. Mandelli The crucial role of the von Willebrand Factor (vWF) and its interaction with platelets in myeloproliferative disorders (MPD) have emerged in recent years. Recently, many authors have reported...

... by another specific substrate for FVIII clotting assays. FVIII-deficient plasma was prepared by immunodepletion using polyclonal anti-von-Willebrand factor (vWF) and monoclonal anti-FVIII antibodies coated to agarose beads. This plasma, deficient in both FVIII and vWF, allows the evaluation of FVIII activity...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. l-Deamino-8- D -arginine vasopressin VIIl:C von Willebrand factor Blood donors Haemostasis 18: 187-196 (1988) © 1988 S. Karger A G . Basel 0301 -0147/88/0183-0187S2.75/0...

...Samuel N. Breit; Ira Green Von Willebrand factor (vWf:Ag) is an important product of endothelial cells whose major known functions are coagulation and platelet adhesion. It appears to behave as an acute-phase reactant, levels being elevated in the plasma in a wide variety of inflammatory disorders...

...Kathy B. Thomas; Barry G. Firkin; Margaret A. Howard Platelet lysates were obtained from suspensions of normal washed platelets by freeze-thawing or Triton X-100 lysis. The resultant platelet lysates contained 0.34 ± 0.15 U/10 9 platelets (n = 8) of von Willebrand factor antigen (vWf:Ag...

...Hoyu Takahashi; Tsuneyasu Tsukada; Wataru Tatewaki; Masaharu Hanano; Masayoshi Sanada; Akira Shibata A fast-migrating precipitin peak which showed a reaction of partial immuno-chemical identity with the major von Willebrand factor (vWf) component was detected by crossed immunoelectrophoresis...

... for thrombin in collagen activation of platelets. Evidence was also obtained that von Willebrand factor may participate in this reaction. 16 4 2009 © 1977 S. Karger AG, Basel 1977 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated...

... with rabbit aorta previously, notwithstanding the essentially different nature of the human subendothelium, with its layers of smooth muscle cells above the internal elastic lamina. The system was used to study the role of factor VIII-von Willebrand factor (VIII-VWF). VIII-VWF was found to be the only plasma...

... to in the content or advertisements. Ristocetin Platelet aggregation Factor VIII Factor VIH-related antigen von Willebrand factor Hemophilia A Exercise Haemostasis 3: 137-141 (1974) Increase of a Plasma Factor Involved in RistocetinInduced Platelet Aggregation after Exercise J. Stibbe a n d P. M...

... metabolism, haemostatic variables and cardiac hypertrophy in patients (n = 109) with coronary heart disease. The plasminogen activator inhibitor-1 activity and the von Willebrand factor were higher in the CC homozygote group compared to the CT/TT group (p < 0.05). There were no differences between...