... reported to occur within the bleeding time wound and infusion of recombinant FVIIa (rFIIa) has been shown to shorten the bleeding time in rabbits. We have investigated whether infusion of rFVIIa would enhance fibrin formation in bleeding time wounds in patients with thrombocytopenia as reflected...

...P. Drakos; B. Uziely; A. Nagler; S. Gillis; A. Eldor A case of heparin-induced thrombocytopenia and skin necrosis induced by coumarin is reported in a 58-year-old female patient suffering from metastatic breast adenocarcinoma and deep vein thrombosis. The thrombosis resolved after treatment...

...J. Storck; N. Höllger; R.E. Zimmermann We present results concerning the pathogenic mechanism of heparin-induced thrombocytopenia type I. An ELISA was developed for directly measuring the expression of glycoprotein IIb/IIIa (GPIIb/IIIa) on platelets in the presence and absence of ADP and under...

...M.A.A. Kratzer; K. Storck; J. Groh A method to determine primary hemostasis ex vivo (Thrombostat) was modified to monitor the transfusion effect of platelet concentrates (PC) in 12 patients with thrombocytopenia following bone marrow transplantation. It was possible to measure platelet function...

...Sharron L. Pfueller; Fernando Cortizo; Jannine Gibson; Robyn Bilston; Ian G. Sloan Quinine-dependent (Q) IgG antibodies (Q.Ab) in drug-induced immune thrombocytopenia are heterogeneous and bind to different platelet surface glycoproteins (GP), namely GPIb, IX, lIb, IlIa and an unidentified 57-kDa...

...M. Hanss; D. Ville; M. Dechavanne Plasma fibrinolytic factors were measured in 14 patients with chronic idiopathic thrombocytopenic purpura (ITP), in 5 patients with chronic central thrombocytopenia and in 16 healthy volunteers. The von Willebrand factor (vWF), tissue-type plasminogen activator (t...

...L. Conti; P. Fidani; A. Chistolini; M. Francesconi; G.M. Gandolfo; M.G. Mazzucconi Drug-induced thrombocytopenia is a common acquired hemorrhagic disorder. In this study 32 patients with drug-induced thrombocytopenia were examined with the anti-globulin consumption assay. Platelet-associated IgG...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Platelets Malondialdehyde Platelet survival Thrombocytopenia Chronic obstructive pulmonary disease Haemostasis 13: 53-60 (1983) © 1983 S...

... not be observed when the number of circulating platelets dropped slowly following intramuscular implantation and spontaneous dissemination of the same cancer cells. These results support previous observations suggesting a different mechanism for the thrombocytopenia observed after intravenous and intramuscular...

...M.G. Doni; P. Vassanelli; L. Bonadiman; G.L. Avventi A study has been performed to evaluate the effect of the portacaval shunt on some coagulation tests in the rats. Thrombocytopenia develops, accompanied by a decrease in the total protein and fibrinogen concentrations. Moreover, the Quick time...

... unfractionated heparin or low-molecular-weight heparin for 3 months. Heparin-induced thrombocytopenia (HIT) antibodies were detected by ELISA in 7 patients (2.3%) who had no history of HIT. Two patients abruptly developed HIT associated with the formation of clots in the extracorporeal circuit after they were...

... ofHaemostasis andThrombosis Original Paper Pathophysiol Haemost Thromb 2003;33:116 119 DOI: 10.1159/000073856 Received: November 11, 2002 Accepted after revision: March 6, 2003 Laparoscopic Splenectomy for Immune Thrombocytopenic Purpura in Patients with Severe Refractory Thrombocytopenia Andrei Keidar Boaz...

...Yves Laurian The mechanism of action of recombinant factor VIIa (rFVIIa), i.e. increased thrombin generation on the membrane of activated platelets, as well as the results from in vitro and ex vivo models of thrombocytopenia or inherited thrombocytopathia may support some potential of rFVIIa...

.... They prevent collagen-induced thrombocytopenia in rats. N- and C-terminal-truncated synthetic L1γ (sL1γ; 11-mer) is less active in inhibiting platelet aggregation than the native peptide. Results from Ala scan studies of the sL1γ peptide indicated that replacement of the residues (P3, G7, P8, P9 or N10...

... the postpartum state for a combined event rate of 12.1% (95% CI 3.4–25.2), three of which resulted in death. The all-cause mortality rate was 20.8% (95% CI 7.3–39.0). Both anemia (event rate 72.7%, 95% CI 56.5–86.3), and thrombocytopenia (event rate 27.3%, 95% CI 13.7–43.5) were common, often necessitating red...

... developed massive intracranial bleeding. Despite an extremely low platelet count (2×10 9 /liter) which was refractory to platelet transfusions, successful emergency splenectomy was performed, with rapid resolution of the thrombocytopenia. Bleeding complications are extremely rare in viral-associated ITP...

... with thrombocytopenia or other hematologic diseases. The use of PEG-rHuMGDF should be safe and not cause an additional risk of thromboocclusive disease in these patients. 18 1 1999 1999 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated...