...T. Fenyvesi; I. Jörg; J. Harenberg Prothrombinase-induced clotting time (PiCT) is a clotting-time test for heparins and direct thrombin inhibitors to reduce drawbacks of aPTT. Effects of the direct thrombin inhibitors lepirudin, argatroban, melagatran and of unfractionated heparin (UFH) were...

... potent agents have been developed, including direct thrombin inhibitors (e.g., hirudin and hirulog) and new antiplatelet agents [e.g., the gly-coprotein Ilb/IIIa receptor inhibitor c7E3 Fab (ReoPro TM )]. Initial phase-III trials of hirudin in patients with acute coronary syndromes identified an excess...

...K. Krupinski; H.K. Breddin; F. Markwardt; W. Haarmann The antithrombotic effects of three thrombin inhibitors (hirudin, NAPAP and argidipine) were investigated in an experimental thrombosis model using laser lesions of rat mesenteric venules. Furthermore, their in vitro anticoagulant activity...

...F. Markwardt Biochemical, pharmacological and first clinical findings on synthetic, low molecular weight inhibitors of serine proteinases of the blood considered to be therapeutically relevant thrombin inhibitors are reviewed. Their effect is due to an inhibition of the thrombin-fibrinogen reaction...

... of recombinant hirudins and hirudin analogues. It has also allowed the molecular design of synthetic antithrombins, and encouraged the development of these products for clinical use. All pharmacological aspects speak in favor of the use of direct thrombin inhibitors as antithrombotic agents, especially...

...H.K. Breddin Hirudin, the specific thrombin inhibitor from medicinal leeches, is now produced by recombinant technology. r-Hirudin and to a lesser extent polyethyleneglycol-coupled hirudin (PEG-hirudin) have been used in many clinical trials. Hirudin has been shown to be more effective than low...

... to investigate platelet-rich thrombolytic mechanisms in vivo and demonstrated that recombinant staphylokinase (rSAK)-induced thrombolysis was enhanced by the concomitant administration of the direct thrombin inhibitor argatroban. The present study expanded the use of this model by comparing arterial and venous...