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Keywords: Thrombin
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Journal Articles
Journal Articles
Journal Articles
Pathophysiology of Haemostasis and Thrombosis (1994) 24 (2): 69–80.
Published Online: 28 April 2009
...Lina Badimon; Beat J. Meyer; Juan J. Badimon Thrombin plays a pivotal role in the pathogenesis of arterial thrombosis. Platelet-rich thrombosis after arterial injury is dependent on the depth and extent of injury, local Theological conditions and the persistence of residual mural thrombus...
Journal Articles
Pathophysiology of Haemostasis and Thrombosis (1996) 26 (Suppl. 2): 2–9.
Published Online: 28 April 2009
... III markedly enhances the ability of the latter to inhibit factor Xa and thrombin. Only about one third of the unfractionated heparin molecules contain the high-affinity material and its distribution along the heparin molecules appears to be random – hence the development of low-molecular-weight...
Journal Articles
Pathophysiology of Haemostasis and Thrombosis (1992) 22 (2): 58–65.
Published Online: 28 April 2009
... catalyses the inactivation of factor Xa and thrombin. Compared to heparin and most low-molecular-weight heparins, Orgaran has a much higher anti-Xa/anti-IIa ratio. The inactivation of factor Xa is mediated by AT III and that of thrombin by both AT III and heparin cofactor II. Compared to heparin, which...
Journal Articles
Pathophysiology of Haemostasis and Thrombosis (1992) 22 (2): 66–72.
Published Online: 28 April 2009
... Xa Factor Ixa Thrombin Prothrombinase Antithrombin III Haemostasis 1992;22:66-72 F A . Ofosu Canadian Red Cross Society, Blood Transfusion Service, and Department of Pathology, McMaster University, Hamilton, Canada Anticoagulant Mechanisms of Orgaran (Org 10172) and Its Fraction with High...
Journal Articles
Journal Articles
Pathophysiology of Haemostasis and Thrombosis (1996) 26 (Suppl. 1): 12–16.
Published Online: 28 April 2009
... not compensate for a lack of factor IX or VIII because the factor Xa activated by VIIa/TF is located on the wrong surface for efficient thrombin generation. 28 4 2009 © 1996 S. Karger AG, Basel 1996 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication...
Journal Articles
Pathophysiology of Haemostasis and Thrombosis (1993) 23 (Suppl. 1): 183–193.
Published Online: 28 April 2009
...Evan Sadler; Steven R. Lentz; John P. Sheehan; Manuel Tsiang; Qingyu Wu Thrombomodulin is an anticoagulant protein cofactor that modulates the substrate specificity of thrombin and promotes the cleavage of protein C. The structure-function relationships of the thrombin-thrombomodulin interaction...
Journal Articles
Pathophysiology of Haemostasis and Thrombosis (1991) 21 (2): 85–90.
Published Online: 24 April 2009
...Raimondo De Cristofaro; Massimo Castagnola The time-dependent release by human α-thrombin of the physiological variants of fibrinopeptide A, i.e. fibrinopeptide A-3-phosphate (FPAP) and des-Ala-fibrinopeptide A (FPAY), has been measured in order to study the kinetic pathway for their hydrolysis...
Journal Articles
Pathophysiology of Haemostasis and Thrombosis (1991) 21 (Suppl. 1): 36–40.
Published Online: 24 April 2009
...M. Spannagl; H. Bichler; H. Lill; W. Schramm Recombinant hirudin, a potent and specific thrombin inhibitor, is considered for anticoagulant therapy. Therefore we developed a fast and sensitive chromogenic assay for its determination in plasma. Samples can be assayed directly if aprotinin, Polybrene...
Journal Articles
Pathophysiology of Haemostasis and Thrombosis (1991) 21 (Suppl. 1): 142–148.
Published Online: 24 April 2009
...G. Nowak; F. Markwardt Various reactions of disseminated intravascular coagulation (DIC) were experimentally induced by infusion of thrombokinase in rats, by administration of endotoxin in rabbits and pigs and by infusion of adrenaline and thrombin in dogs. Low plasma concentrations of recombinant...
Journal Articles
Pathophysiology of Haemostasis and Thrombosis (1990) 20 (Suppl. 1): 81–92.
Published Online: 24 April 2009
...H.C. Hemker; S. Béguin Heparins, unfractionated and low molecular weight, act primarily by their scavenging of thrombin (S-type heparins). Via the feedback effect on factor VIII this has a secondary effect on prothrombin conversion in the intrinsic pathway (activated partial thromboplastin time...
Journal Articles
Journal Articles
Pathophysiology of Haemostasis and Thrombosis (1991) 21 (4): 254–257.
Published Online: 24 April 2009
..., instructions or products referred to in the content or advertisements. Heparin Thrombin Fibrinopeptide A Coagulation inhibitors Antithrombin Extrinsic pathway inhibitor Haemostasis 1991;21:254-257 © 1991 S. Karger A G , Basel 0301-0147/91/0214-02 54$2.75/0 Heparin Requires both Antithrombin...
Journal Articles
Journal Articles
Journal Articles
Pathophysiology of Haemostasis and Thrombosis (1987) 17 (4): 189–194.
Published Online: 23 April 2009
... of human albumin on gels of human fibrin, clotted with human thrombin, was studied. The addition of albumin, at concentrations from 3 to 30 µ M , to 1 mg/ml fibrin gels produced less than a 10% change in either the kinetics of turbidity increase or the subsequent fiber mass-length ratio. For a given...
Journal Articles
Pathophysiology of Haemostasis and Thrombosis (1985) 15 (3): 164–168.
Published Online: 21 April 2009
...Yuji Hitomi; Nobuhiko Ikari; Setsuro Fujii The inhibitory effects of 6-amidino-2-naphthyl-4-guanidinobenzoate·dimeth-anesulfonate (FUT-175) on the human Hageman factor fragment (HFf), factor Xa, thrombin, plasma kallikrein, and plasmin were studied. FUT-175 inhibited plasma kallikrein most (IC 50...
Journal Articles
Pathophysiology of Haemostasis and Thrombosis (1985) 15 (5): 293–299.
Published Online: 21 April 2009
...Dominique Léger; A. Karniguian; J. Soria; C. Soria; Y. Legrand The effect of a collagen-derived octapeptide on some properties of thrombin is presented. This peptide provoked a dose- and time-dependent prolongation of the thrombin-induced plasma and fibrinogen clotting time and inhibited...