...Taker M. Farid; Anthony T. Tu; Farid El-Asmar Cerastobin, a thrombinlike enzyme with arginine esterase activity, was purified from crude Cerastes vipera (Egyptian Sahara snake) venom. Unlike thrombinlike enzymes isolated from other snake venoms, cerastobin had a potent platelet aggregatory effect...

...-A lacking the C-terminal heparin binding region significantly reduced mitogenic activity. Recently, we found novel heparin-binding VEGFs from snake venoms, designated VEGF-Fs, which specifically recognize kinase domain containing receptor (KDR). The C-terminal heparin-binding region is almost completely...

... Hemostasis Snake venom Exon-intron boundary Pathophysiol HaemostThromb 2005;34:205 208 DOI: 10.1159/000092425 Gene Structures of Trocarin D and Coagulation Factor X, Two Functionally Diverse Prothrombin Activators from Australian Rough Scaled Snake M. Abu Rezaa Sanjay Swarupa R. Manjunatha Kinia, b...

... to in the content or advertisements. Snake venom Recombinant disintegrin Contortrostatin Breast cancer Anti-angiogenesis 19 5 2006 Pathophysiol HaemostThromb 2005;34:177 183 DOI: 10.1159/000092419 Development of a Novel Recombinant Disintegrin, Contortrostatin, as an Effective Anti-Tumor...

...J. Siigur; K. Tõnismägi; K. Trummal; A. Aaspõllu; M. Samel; H. Vija; J. Subbi; N. Kalkkinen; E. Siigur Snake venoms contain four classes of metalloproteases that all have a typical zinc-chelating sequence (HEXXHGXXH). N-terminal sequences and internal sequences of different purified...

...Stephen Swenson; Fritz Costa; William Ernst; Gary Fujii; Francis S. Markland Disintegrins are soluble peptides found in snake venom. They bind to Arg-Gly-Asp (RGD)-responsive integrins with high affinity (n M range) and block integrin function. Contortrostatin (CN), the disintegrin from southern...

...Yajnavalka Banerjee; Jun Mizuguchi; Sadaaki Iwanaga; R. Manjunatha Kini Snake venom is a veritable gold mine of bioactive molecules, capable of binding to a wide variety of pharmacological targets, including the blood coagulation cascade. Here, we report the isolation and characterization of two...

...Reto Schöni Pentapharm Ltd. has a long tradition of producing and proceeding snake venom components as APIs and tools in pharmaceutical and diagnostic applications, beginning with the snake venom-derived product Reptilase ® about 60 years ago. In recent years diagnostic test kits in the field...

..., instructions or products referred to in the content or advertisements. Bothrojaracin Snake venom Anti-thrombotic effects Thrombin Prothrombin Pathophysiol HaemostThromb 2005;34:160 163 DOI: 10.1159/000092416 Bothrojaracin, a Bothrops jararaca Snake Venom-Derived (Pro)Thrombin Inhibitor, as an Anti...

... potency of VEGF-A165 lacking the C-terminal heparin-binding region is less than 1% compared with intact VEGF-A165. We previously found novel heparin-binding VEGFs, designated VEGF-F that specifically recognizes KDR in snake venoms. VEGF-Fs almost completely lack the C-terminal heparin-binding region...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Ovarian cancer Adhesion Invasion Integrin Snake venom Disintegrin Angiogenesis Animal model Substances Affecting Platelet Function...

...Kenneth J. Clemetson; Alexei Navdaev; Dagmar Dörmann; Xiao-Yan Du; Jeannine M. Clemetson Snake venoms contain a wide range of components, many of which affect haemostasis by activation or inhibition of platelets or coagulation factors. They can be classified into groups based on structure and mode...

...N. Marrakchi; K. Mabrouk; I. Regaya; S. Sarray; M. Fathallah; H. Rochat; M. El Ayeb Lebetins from Macrovipera lebetina snake venom constitute a new class of inhibitors of platelet aggregation. There are two groups of peptides: lebetin 1 (L1; 11- to 13-mer) and lebetin 2 (L2; 37- to 38-mer...

... Proteases Snake venom Vipera lebetina Glycoprotein MALDI-TOF MS Substrate specificity Fibrinolysis Haemostasis 2001;31:123 132 Proteases from Vipera lebetina Venom Affecting Coagulation and Fibrinolysis J. Siigur A. Aaspo llu K. To nismägi K. Trummal M. Samel H. Vija J. Subbi E. Siigur National...

... properties of snake venom factor X activators thus far described in the literature. 25 3 2002 © 2002 S. Karger AG, Basel 2002 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any...

.... Snake venom Procoagulants Prothrombin activators Factor Xa Procoagulant Proteins and Diagnostic Agents Haemostasis 2001;31:234 240 Snake Venom Prothrombin Activators Homologous to Blood Coagulation Factor Xa Jeremiah S. Josepha,d R. Manjunatha Kinib,c aDepartment of Biochemistry, Faculty...

.... Anticoagulant Secreted phospholipase A 2 Snake venom Mammalian Factor Xa Factor Va Anticoagulant Proteins and Diagnostic Agents Haemostasis 2001;31:279 287 Anticoagulant Venom and Mammalian Secreted Phospholipases A2: Protein- versus Phospholipid-Dependent Mechanism of Action Carine M. Mouniera Cassian...

... V can also be activated by a wide variety of snake venoms (e.g. from Vipera species, Naja naja oxiana , Bothrops atrox ) and by proteases present in the bristles of a South American caterpillar (Lonomia achelous) . Some venoms, notably of Vipera lebetina turanica and Lonomia achelous, contain...

... and to the other snake venom proteins of the C-type (Ca 2+ -dependent) lectin superfamily. Lebecetin shows a potent inhibitory effect on whole blood and washed platelets induced by different agonists. It inhibits the agglutination of human fixed platelets in the presence of ristocetin. Lebecetin also interferes...

...A. Wisner; S. Braud; C. Bon Snake venom serine proteinases affect many steps of the blood coagulation cascade. Each of them usually acts selectively on one coagulation factor. They are therefore potentially useful components to study the mechanisms of action, the regulation and the structure...