...Niaz Ahmed Choudhury; Jolanta Malyszko; Motahar Hossain Ahmed; Michal Henryk Pietraszek; Satoshi Nakamura; Katsuhiko Nakai; Mohammad Abdur Rashid; Akikazu Takada; Shozo Baba Platelet aggregation and plasma serotonin were studied during ischemia-reperfusion of the small intestine in dogs. Blood...

...Tetsumei Urano; Jolanta Malyszko; Yumiko Takada; Akikazu Takada In order to investigate a possible relationship between serotonergic and fibrinolytic systems, serotonin (5-hydroxytryptamine, 5-HT) metabolism was modified by the use of a monoamine oxidase inhibitor (tranylcypromine: 10 mg/kg body...

...-blood and plasma serotonin and its metabolite 5-hydroxyindoleacetic acid were also higher in the stressed rats and whole-blood serotonin level showed a negative correlation with tPA in the stressed rats. Either stress and/ or its duration are responsible for changes in both fibrinolytic and serotonergic...

... as mental stressor. Platelet responses to serotonin, ADP and collagen, as well as plasma catecholamine levels were assayed. Plasma serotonin levels had a high negative correlation with the bleeding time. Stress resulted in an increase in platelet responses to serotonin, ADP and to the elevation...

...J. Arnout; M. van Russelt; H. Deckmyn; J. Vermylen Ketanserin is a well-known serotonin S 2 receptor antagonist but its capacity to inhibit serotonin-induced aggregation ex vivo during chronic administration has been a matter of debate. In vitro evidence is presented that the inhibitory capacity...

...Harold E. Sweetman; David Shepro; Herbert B. Hechtman The effect of serotonin on vascular fragility, visible as petechiae, was examined in antiplatelet serum-induced thrombocy topenic hamsters. Serotonin was administered intravenously or intraperitoneally, and following a single injection of 0.5 mg...

...-induced aggregation. Ditazole strongly inhibited the release of platelet-bound 14 C-serotonin under the influence of Thrombofax, whereas it did not interfere with the transport and storage of serotonin in nonstimulated platelets. The effect of ditazole was not potentiated by acetyl-salicylic acid...

...M.R. Hardeman; H.K. Prins It is confirmed that metabolic energy is a prerequisite for the uptake of serotonin by human blood platelets. Starvation (i.e. incubation at 25 °C of platelets resuspended in glucose-poor autologous plasma) generally stops glucose consumption, lactate formation as well...