...Erika Glusa; Fritz Markwardt The influence of genetically engineered recombinant hirudin (r-hirudin) on platelet functions was studied. Depending on the concentration, r-hirudin inhibits the thrombin-induced aggregation and 14 C-serotonin secretion to the same extent as native hirudin. Comparative...

...E. Glusa Recombinant hirudin (r-hirudin) inhibited the thrombin-induced aggregation and 14 C-serotonin secretion of human platelets in the same concentration range as native hirudin. In r-hirudinized blood, lower spontaneous platelet aggregation was found than in citrated or heparinized blood...