... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Recombinant hirudin Antidote Animal models Whole blood coagulation time Bleeding time Original Paper Haemostasis...

...Stefan E. Matthiasson; Bengt Lindblad; David Bergqvist In a randomized, blind study the antithrombotic efficacy of dermatan sulphate (DS), recombinant hirudin (r-hirudin) and four commercially available low molecular weight heparins (LMWHs) was investigated after intravenous administration...

...Stefán E. Matthíasson; Bengt Lindblad; Ulf Stjernquist; David Bergqvist In a randomized, blind study the primary effect on haemostasis after intravenous administration of dermatan sulphate (DS), recombinant hirudin (r-hirudin) and four commercial low molecular weight heparins (LMWHs) (nadroparine...

...J.F. Schenk; E. Glusa; P. Radziwon; A. Butti; F. Markwardt; H.K. Breddin The pharmacodynamic effects of different intravenous and subcutaneous doses of a recombinant hirudin (r-hirudin; IK-HIR02) on clotting parameters and bleeding time were investigated in 24 healthy volunteers in a bicenter study...

...Erika Glusa; Fritz Markwardt The influence of genetically engineered recombinant hirudin (r-hirudin) on platelet functions was studied. Depending on the concentration, r-hirudin inhibits the thrombin-induced aggregation and 14 C-serotonin secretion to the same extent as native hirudin. Comparative...

...Jawed Fareed; Jeanine M. Walenga; Roque Pifarre; Debra Hoppensteadt; Mike Koza Recombinant hirudin (r-hirudin) is currently under development as an anticoagulant for use in surgery, therapeutic anticoagulation, disseminated intravascular coagulation and other pathologic states involving...

...Jeanine M. Walenga; Debra Hoppensteadt; Michael Koza; Michael Wallock; Roque Pifarre; Jawed Fareed Several laboratory methods are available to measure the anticoagulant activity of recombinant hirudin (r-hirudin), a potent thrombin inhibitor. These assays include clot-based, amidolytic, immunologic...

...Melitta Just; Dominique Tripier; Dirk Seiffge The effect of recombinant hirudin (r-hirudin; HBW 023) was studied in four different models of thrombosis as well as on bleeding time. Arteriolar thrombus formation was induced in rats either by argon laser injury or by photochemical reaction. r-Hirudin...

... to in the content or advertisements. Disseminated intravascular coagulation Recombinant hirudin Thrombokinase Endotoxin Adrenaline Thrombin Haemostasis 1991 ;21(suppl 1): 142-148 © 1991 S. Karger AG. Basel 0301 -0147/91 /0217-0142S2.75/0 Hirudin in Disseminated Intravascular Coagulation G. Nowak, F...

...K. Rübsamen; V. Eschenfelder The effect of recombinant hirudin (r-hirudin, LU 52369) and unfractionated heparin on recombinant tissue-type plasminogen activator (rt-PA; LU 50232) thrombolysis and reocclusion rates after successful thrombolysis was studied in a copper-coil-induced thrombus model...

... to in the content or advertisements. Recombinant hirudin Protein folding Reverse-phase HPLC Synthetic peptides Thrombin exosite Haemostasis 1991 ;21(suppl 1): 41-48 © 1991 S. Kargcr AG, Basel 0301-0147/91 /0217-0041 $2.75/0 Structure-Function and Refolding Studies of the Thrombin-Specific Inhibitor...

... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Recombinant hirudin Hemodialysis Pharmacokinetics Haemostasis 1991 ;21(suppl 1): 149...

...C. Doutremepuich; M.C. Lalanne; F. Doutremepuich; J. Walenga; J. Fareed; H.K. Breddin Three recombinant hirudins (r-hirudins) produced by genetic processes from Escherichia coli and yeast were studied. r-Hirudins could be an alternative treatment to heparin; so, the antithrombotic activity...

...M. Basic-Micic; Ch. Rauschenbach; H.K. Breddin The effect of two recombinant hirudins, HBW 023 (Hoechst AG, Frankfurt, FRG) and CGP 39393 [recy(tyr 63)] (Ciba Geigy, Basel, Switzerland) on various platelet functions has been investigated in blood samples of healthy volunteers anticoagulated...

...E. Glusa Recombinant hirudin (r-hirudin) inhibited the thrombin-induced aggregation and 14 C-serotonin secretion of human platelets in the same concentration range as native hirudin. In r-hirudinized blood, lower spontaneous platelet aggregation was found than in citrated or heparinized blood...

... experiments. Genetic engineering led to the availability of sufficient quantities of recombinant hirudin (r-hirudin) for clinical purposes. Pharmacologic profiling of r-hirudin showed that both its pharmacokinetic and pharmacodynamic characteristics are very similar to those of native hirudin. Clinical...

...W. Raake; R.J. Klauser; H. Elling; P. Zeiller The dose- and time-dependent antithrombotic activity of recombinant hirudin (r-hirudin) was examined in a new animal model of venous thrombosis. For the evaluation of the antithrombotic activity of r-hirudin, an occluding thrombus was produced...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Leeching Hirudo medicinalis Recombinant hirudin Haemostasis 1991 ;21(suppl 1):3 10 © 1991 S. Karger AG, Basel 0301 -0147/91/0217-0003$2.75/0 The History of Leeching and Hirudin...

...F. Markwardt; G. Nowak; J. Stürzebecher Pharmacological profiling of recombinant hirudin (r-hirudin) has shown that this selective tight-binding thrombin inhibitor is a potent, well-tolerated anticoagulant. Clinical pharmacological studies were performed in human volunteers after single...