...Klas Norrby The systemic effect of 2.4-, 8-, 15- and 22-kDa heparin fractions on saline-mediated angiogenesis in rats was compared with the systemic effect of an unfractionated Na-standard heparin (UFH), which had a mean molecular weight of about 15 kDa. Using the mesenteric-window assay in adult...

... of conventional heparin. Studies with organ perfusion in rats show that the two types of heparin have similar ability to release the lipases from their binding sites in extrahepatic tissues, but that LMW heparin is less effective than conventional heparin in preventing rapid uptake and degradation of LPL...

...J. Yamamoto; I. Ishii; Y. Sasaki; Y. Nagamatsu; T. Matsuda; E. Ando The inhibitory effects of ticlopidine and acetylsalicylic acid (ASA) on thrombus formation in rat mesenteric microvessels were studied. The results were compared with the effect of the drugs on platelet aggregation in citrated...

...W.A. Schumacher; C.L. Heran; S. Youssef; J.R. Megill; I. Michel; S.K. Durham The antithrombotic activities of aspirin, the thromboxane (Tx) A 2 /prostaglandin endoperoxide-receptor (TP-receptor) antagonist, SQ 30,741, and heparin were determined in anesthetized rats. Heparin (3 doses of 50, 300 U...

...Lawrence J. Smith; Keith L. Schaible; Richard G. Fessler; Jacob R. Rachlin; Frederick D. Brown The feasibility of employing the rat as an experimental model for investigation of full-dose heparin anticoagulation was assessed. Striking similarities were found to exist between rats and humans...

...A. Smokovitis; T. Astrup Histochemical studies of the distribution of fibrinolytic activity in the vagus and sciatic nerves of rat, guinea pig, and rabbit showed large areas of diffuse lysis related to the fascicles of the nerve. Foci of lysis were also located in the perineurium, in the peripheral...

...A. Smokovitis; E. Hattey; B.R. Binder The response of the fibrinolytic system to hypophysectomy in the rat was studied. 4 and 6 weeks after hypophysectomy the tissue plasminogen activator activity (PAA) was significantly increased in the intima of the aorta, slightly but significantly increased...

...Michael Cohn; Yaacov Matzner; Amiram Eldor The ex vivo effect of oral administration of ticlopidine on rat neutrophil chemotaxis was evaluated. Rats received either 3 oral doses (100 mg/kg body weight) of the drug, within a period of 48 h, via a gastric tube, or the drug was administered...

...A. Smokovitis; W. Auerswald; K. Müller; P. Clopath; B.R. Binder In a strain of genetically hypercholesterolemic rats (RICO), developed from an albino mutant of Rattus norvegicus (Sprague-Dawley, Tif: RAIf, SPF) by selective breeding, the intimal plasminogen activator activity (PAA...

...A. Smokovitis Histochemically studied, the heart, spleen, liver, kidney cortex, lung, sciatic nerve, gastrocnemius muscle, skin and tongue showed a higher fibrinolytic activity (plasminogen activator activity) in the newborn than in the adult rat. In the medulla of the kidney the activity...

...J.J. Emeis; J. Lindeman Disseminated intravascular coagulation was induced in rats by injection of a silver colloid suspension or thrombin. Ten min after the injection of colloid, fibrin deposits were observed light microscopically in all major organs. At 30 min, fibrin was no longer present...

...J. Pratt; P. Boudeau; A. Uzan; A. Imperato; J.-M. Stutzmann This study investigates the effect of enoxaparin (Lovenox, Klexane), a low-molecular-weight heparin, on edema following a photothrombotic lesion using rose bengal dye in the rat. An area of cerebral ischemia was provoked in the right...