...A. Moreno; J.P. De La Cruz; F. Mérida; J. García Campos; F. Sánchez de la Cuesta Platelets from diabetic patients are hypersensitive to aggregating agents. An imbalance in thromboxane/prostacyclin synthesis has been postulated as an antecedent to the development of diabetic retinopathy. We studied...

...G. Togna; M. Graziani; C. Sorrentino; L. Caprino To extend our previous in vitro data, we investigated the effects of cocaine on thromboxane A 2 (TXA 2 ) and prostacyclin (PGI 2 ) production in vivo in the rat. To obtain the slight platelet activation that our in vitro experiments showed useful...

...Ralf Scherer; Ulrich Schmidt; Wolfgang Kox; Dietrich Paar Endotoxin infusion (lipopolysaccharide from Escherichia coli 120 μg kg –1 i.v.) was titrated to produce hypercoagulability in rabbits and the effects of prostacyclin (PGI 2 ) treatment (continuous infusion of 6 ng kg –1 min –1 i.v...

...Lillian Nordbø Berge; John-Bjarne Hansen; Birgit Svensson; Vegard Lyngmo; Arne Nordøy The effects of estradiol and progesterone added to the growth medium of human umbilical vein endothelial cells for 72 h on the formation and release of prostacyclin were investigated. The influence on collagen...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Endothelium Anticoagulants Prostacyclin Vascular anticoagulant Extrinsic pathway inhibitor Glycosaminoglycans...

...Rosemary Zaragoza; Guy C. Le Breton The present study investigated the sensitivities of the thromboxane A 2 (TXA 2 ) cyclooxygenase and the prostacyclin (PGI 2 ) cyclooxygenase to aspirin using an in vivo animal model. In this model, arachidonic acid (AA) was administered to mice via cardiac...

..., University of Göttingen; bInstitute of Immunology and Oncology of Bayer AG, Wuppertal, FRG Key Words. Endothelium Platelet aggregation Thrombosis Prostacyclin Streptokinase Aspirin Factor VIII (AHF) Heparin Abstract. Platelet adherence and aggregation on vessel walls are the first crucial steps...

...Guido Fumagalli; Erenia Angelaccio; Nunzio Lombardo; Francesco Clementi Defibrotide is a profibrinolytic agent which has potent stimulatory effects on vascular prostacyclin (PGI 2 ) production and secretion. We have studied the effects of this substance on the morphological organization of venous...

...A.R. Saniabadi; J.J.F. Belch; G.D.O. Lowe; J.C. Barbenel; C.D. Forbes Prostacyclin (PGI 2 ), an unstable endogenous prostanoid, is a potent vasodilator and inhibitor of platelet aggregation. The use of exogenous PGI 2 as an antithrombotic agent is limited by its chemical instability and lack...

...R.F.A. Zwaal; P. Comfurius; H.C. Hemker; E.M. Bevers Prostacyclin is able to inhibit the development of platelet prothrombinase activity. This inhibition, which also occurs with dibutyryl cAMP, is presumably due to the ability of prostacyclin to prevent the formation of a negatively charged...

...A.R. Saniabadi; G.D.O. Lowe; J.J.F. Belch; J.C. Barbenel; C.D. Forbes Prostacyclin (PGI 2 ) is a potent endogenous inhibitor of platelet aggregation. The effect of PGI 2 on platelet aggregation and disaggregation in whole human blood was studied at 37 °C in vitro. Aggregation or disaggregation...

...T. Inoguchi; F. Umeda; J. Watanabe; H. Ibayashi Reduced prostacyclin (PGI 2 ) production by the vascular wall has been proposed as a possible cause of macro- or microangiopathy in diabetes mellitus. In the present study, we confirmed the stimulatory activity on PGI 2 (PSA) production in plasma...

... concentrations of cocaine were added; on the other hand, high doses of the anaesthetic were found to block the aggregating effects of these two agents. Specific studies showed cocaine to have an inhibitory activity on prostacyclin release when the aortic tissue was mechanically and thermically stimulated...

.... Myocardial ischemia Lethal ventricular fibrillation Defibrotide Prostacyclin Lactate Adenosine triphosphate Creatine phosphokinase Haemostasis 16: suppl. 1, pp. 18-25 (1986) ©1986 S. Kargcr AG. Basel 0301-0147/86/0167-0018S2.7S/0 Cardioprotective Effects of Defibrotide in Acute Lethal and Nonlethal...

... activity as D; heparin (76 IU kg –1 h –1 ) was completely ineffective and PGI 2 showed a modest activity at 60 nmol kg –1 h –1 . The antithrombotic and thrombolytic activities of D may be partly due to its ability to promote release of plasminogen activator factor and of prostacyclin from vascular tissue...

.... Myocardial ischemia Defibrotide Prostacyclin P-Adrenergic receptors Creatine phosphokinase Abstract. Defibrotide is a polydeoxyribonucleotide of mammalian origin which possesses profibrinolytic effect and PGD-releasing capacity. Because of these properties, defibrotide has antithrombotic effects which...

...G. Gerő; I. Rákóczi; K. Tihanyi; J. Oláh; J. Demeter; I. Gáti Platelet sensitivity to adenosine diphosphate (ADP) and to prostacyclin (PGI2) was studied in normal and diabetic pregnant women. The threshold concentrations of ADP inducing the second phase of aggregation were used to determine...

... week throughout the whole study period (9–11 months). From these animals aorta was removed for prostacyclin bioassay based upon its platelet aggregation inhibitory effect. The diabetic rats treated with Bay g 6575 released significantly more prostacyclin than the controls (p < 0.005). Our study...

... activation. Vascular prostacyclin inhibits vessel-wall-induced clotting of platelet-rich plasma, possibly by inhibiting platelet activation. Type and amount of dietary fats were shown to influence vessel-wall-induced clotting via at least four different mechanisms, namely: by modifying vascular prostacyclin...

...S. Moncada; J.L. Amezcua Prostacyclin and thromboxane A 2 are products of arachidonic acid which play a role in the regulation of haemostatic plug and thrombus formation. Aspirin inhibits the synthesis of both compounds but is more active in blocking TXA 2 formation; based on this, aspirin...