...E. Pretorius Platelets and fibrin play an important role in the coagula- tion process where they are involved in the maintenance of haemostasis. Many diseases like cancer, thrombotic disease, bleeding disorders, asthma and even conditions like HIV/AIDS are associated with ultrastructural changes...

...Meinrad P. Gawaz; Caroline Bogner; Hans J. Gurland Platelet dysfunction and increased bleeding tendency has been the most consistently described haemostatic abnormality in patients with renal failure. Besides abnormalities in platelet membrane glycoproteins, a reduced amount of platelet-dense...

... samples for platelet function studies and for the determination of epinephrine levels in serum were taken in basal conditions, at the end of mental stress and after 30 min of recovery. Patients were studied twice, in washout of medications and after oral administration of dipyridamole, 200 mg twice a day...

...A.C. van Hof; J.M.H. Ubachs; J.W.J. van Wersch The slide test method of Velaskar and Chitre for determining platelet aggregation in whole blood after induction of aggregation was modified for spontaneous platelet aggregation and evaluated. The reproducibility was satisfactory (CV 1-3%). The results...

...Patrizia Noris; Giampiera Bertolino; Mario Previtali; Maurizio Ferrario; Carlo L. Balduini We investigated ex vivo spontaneous platelet aggregation (SPA) in platelet-rich plasma in 37 patients with acute myocardial infarction. It occurred in about 50% of subjects receiving heparin after...

...Paolo Perutelli; Patrizia Marchese; Pier Giorgio Mori Glanzmann’s thrombasthenia is a rare hemorrhagic syndrome, characterized by a quantitative or functional defect of the platelet glycoprotein GPIIb-IIIa complex. The authors describe a method to diagnose thrombasthenic patients and identify...

...M. Bazzan; G. Tamponi; E. Gallo; S. Stella; P.C. Schinco; A. Pannocchia; A. Pileri Thrombotic and hemorrhagic complications are frequent in patients with essential thrombocythemia (ET), a myeloproliferative syndrome with an increased number of circulating platelets. Since platelets...

...Rosa Hernández; Mónica Alemany; Jordi Bozzo; Michael R. Buchanan; Antonio Ordinas; Eva Bastida Interactions between blood platelets and polymorphonuclear leukocytes (PMN) influence cell reactivity. We have examined the effects of inhibiting platelet and PMN cyclooxygenase and lipoxygenase pathways...

... thrombin inhibitor recombinant hirudin to prevent TF-induced coagulation activation in a rabbit model. Infusion of 0.5 μg·kg –1 •h –1 TF in rabbits for 7 h led to a decrease in fibrinogen and platelets, to an increase in fibrin monomers and to a prolongation of TT, aPTT and PT. Recombinant hirudin...

...B. Polack; F. Delolme; F. Peyron The role of blood platelets in the pathogenesis of malaria remains unclear. In this study we investigated the role of experimentally caused thrombocytopaenia in chronic (Balb/C) and acute (CBA/J) Plαsmodium - berghei -induced murine malaria. A group of 30 Balb/C...

....) on coagulation variables, cardiorespiratory variables, and fibrin deposition in the microcirculation of vital organs were studied. PGI 2 infusion did not influence the concentration of soluble fibrin, throm-belastographic variables, or systemic platelet aggregability. Fibrin deposition in the microcirculation...

...Guoxin Wu; Changgeng Ruan; Ludovic Drouet; Jacques Caen KRDS (Lys-Arg-Asp-Ser), a tetrapeptide from human lactotransferrin, was tested for its effects in vitro on dog platelet function and in vivo on femoral arterial thrombus formation in dogs. KRDS inhibited ADP (8 μM )-induced platelet...

... in hemostasis. Factor Xa activated on a tissue factor (TF)-bearing cell is not equivalent to factor Xa activated on a platelet surface. Factor IX and factor VIII are required for hemostasis because they combine to generate factor Xa on the platelet surface. Factor X activation by factor VIIa/TF does...

...Chiara Cerletti; Virgilio Evangelista; Giovannni de Gaetano 28 4 2009 Platelets PMN leukocytes cell-cell interaction cathepsin G P-selectin b2 integrins Haemostasis 1996; 26 (Suppl 4): 20-27 PLATELET-POLYMORPHONUCLEAR LEUKOCYTE FUNCTIONAL INTERACTIONS: ROLE OF ADHESIVE...

...Alan T Nurden Platelets play a key role in arterial thrombosis. Inhibition of platelet function forms an essential part of anti-thrombotic therapy. Although aspirin is a cost-effective drug which offers considerable scope in the prevention of arterial thrombosis, it only inhibits part...

...Barry S. Coller; Keaven M. Anderson†; Harlan F. Weisman† The platelet GPIIb/IIIa receptor mediates platelet aggregation induced by all physiologic agonists. Blockade of the receptor, either by monoclonal antibodies or small molecules patterned after the arginine glycine-aspartic acid (RGD) cell...

... for binding resulting both from the different concentrations of constitutent proteins and their relative affinities for heparin. In the blood heparin binds to platelets in a saturable, specific and reversible interaction which occurs in the presence of competing plasma proteins and which may be prothrombotic...

...A. Moreno; J.P. De La Cruz; F. Mérida; J. García Campos; F. Sánchez de la Cuesta Platelets from diabetic patients are hypersensitive to aggregating agents. An imbalance in thromboxane/prostacyclin synthesis has been postulated as an antecedent to the development of diabetic retinopathy. We studied...

...A. Wehmeier; R.E. Scharf; S. Fricke; W. Schneider Bleeding and thrombosis are a major cause of morbidity and mortality in myeloproliferative disorders (MPD). This study evaluates the relation between thrombohemorrhagic complications and platelet abnormalities in different subgroups of MPD. In 57...

...Jacques C. Giltay; Jan A. van Mourik Studies on the identification of molecules involved in the interaction of endothelial cells with their environment have led to the discovery of membrane receptors that are similar or identical to previously characterized platelet membrane glycoproteins. Some...