... activator (tPA) and plasminogen activator inhibitor-1 (PAI-1) was tested in 65 healthy volunteers (31 men and 34 women; aged 20-74 years) in a randomized, blind, placebo-controlled, crossover study lasting 10 weeks (run-in phase 2 weeks, tea and placebo phases 4 weeks). During the placebo phase, intakes...

... (TNF) at the doses of 0.8 μg/kg/h (n = 5) and 8 μg/kg/h (n = 3) or with endotoxin (8 μg/kg/h, n = 7). Animals infused with vehicle (n = 11) served as control group. Plasminogen activator (PA) activity of glomerular extracts from rabbits infused with 8 μg/kg/h of TNF or endotoxin was significantly lower...

...A. Smokovitis; N. Kokolis; I. Taitzoglou Plasminogen activator activity (PAA), plasminogen activator inhibition (PAI) and plasmin inhibition (PI) have been studied with spectrophotometric methods in extracts of human, bovine, ovine and rat kidneys of both sexes. In all species studied, renal PAA...

...H.-P. Klöcking; Anna Hoffmann; F. Markwardt In the isolated perfused pig ear, batroxobin caused a dose-dependent increase in the release of plasminogen activator. The activator-releasing effect required the presence of the active enzyme. The activator released was of the tissue-type. 28 02...

...Utako Okamoto; Yoko Nagamatsu; Junichiro Yamamoto; Sayoko Ikeda; Akira Kubota In streptozotocin-induced diabetes in rats, nonplasmin fibrinolytic activity was found to be significantly increased in the lung and spleen, but not in the liver and kidney. The plasminogen-activator activities, either...

...A. Smokovitis; N. Kokolis; E. Alexaki-Tzivanidou Marked changes of the plasminogen activator activity, plasmin inhibition, and plasminogen activator inhibition were found in fatty streaks and fibrous plaques compared to the normal intima of the human aorta. Plasminogen activator activity...

...O. Matsuo; T. Sakai; H. Bando; K. Okada; S. Nakajima; O. Takagi; S. Izaki Plasminogen activator was purified from the soluble fraction of bronchoalveolar lavage fluid, and biological and immunological characteristics of the activator were examined by electrophoretic enzymography. The purified...

... epineurium, and particularly in the epineurium between the fascicles of the nerve. The fibrinolytic activity was caused by a plasminogen activator. The activity was highest in the rat, lowest in the rabbit and intermediate in the guinea pig. Plasmin inhibitors were located histochemically by the fibrin slide...

...A. Smokovitis; E. Hattey; B.R. Binder The response of the fibrinolytic system to hypophysectomy in the rat was studied. 4 and 6 weeks after hypophysectomy the tissue plasminogen activator activity (PAA) was significantly increased in the intima of the aorta, slightly but significantly increased...

...A.M.A. Gader In an attempt to investigate the effect of the proposed interaction between corticosteroids and adrenaline in stressful situations on fibrinolysis and coagulation, blood plasminogen activator and clotting factor VΠI were measured before and after a prolonged adrenaline infusion (3.5 μg...

...Sixtus Thorsen; Tage Astrup It has previously been shown, that large differences exist between the effects of 6-aminohexanoic acid or α 1 -antitrypsin on fibrinolysis caused by a porcine tissue plasminogen activator or by human urokinase, while insignificant differences exist between the effects...

... by a plasminogen activator and is related to blood vessels. Occasionally, intense fibrinolytic activity was also observed in some specimens collected from various other organs normally low in activity. Thus two specimens of rabbit aorta, one specimen of rabbit trachea and one specimen of rabbit stomach showed...

...Athan. Smokovitis Histochemical studies of the aorta in newborn, young, and adult rats showed that the intima in the branching regions and at the beginning of the branches has a constantly increased plasminogen activator activity in comparison with the nonbranching regions. The aortic valve also...

... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Fibrinolysis Plasminogen activator Haemostasis 9: 248 256 (1980) Effects of Dextran...

... used for the estimation of plasmin and plasminogen activator activity. Activator activity could be demonstrated in sterile bile and saliva. When plasmin activity was present, estimations of plasminogen activator were approximate. The method is sensitive, small volumes of reagents and samples are needed...

.... Fibrinolysis Plasminogen activator Plasmin Inhibitor Lung diseases Animal lungs Haemostasis 6 : 318-328 (1977) A Histochemical Study of Fibrinolytic Activity and Inhibition of Plasmin in the Lungs of Some Animal Species A thanasios Smokovitis an d T age A strup Gaubius Institute, Health Research...

...G. de Gaetano; G. Remuzzi; M. Mysliwiec; M.B. Donati In several experimental and clinical conditions associated with thrombotic tendency, or complicated by thrombotic episodes, either prostacyclin (which inhibits platelet aggregation) or plasminogen activator (which promotes fibrinolysis), or both...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Fibrinolytic system Contraceptive hormones Plasminogen activator...

... Prothrombin activator Plasminogen activator Pathophysiol HaemostThromb 2005;34:200 204 DOI: 10.1159/000092424 Serine Proteases Affecting Blood Coagulation and Fibrinolysis from Snake Venoms R. Manjunatha Kini Department of Biological Sciences, Faculty of Science, National University of Singapore...

...Wolf-Dieter Schleuning Plasminogen activators are enzymes found in all vertebrate species investigated so far. Their physiological function is the generation of localized proteolysis in the context of tissue remodeling, wound healing and neuronal plasticity. The common vampire bat (Desmodus...