...P. Drakos; B. Uziely; A. Nagler; S. Gillis; A. Eldor A case of heparin-induced thrombocytopenia and skin necrosis induced by coumarin is reported in a 58-year-old female patient suffering from metastatic breast adenocarcinoma and deep vein thrombosis. The thrombosis resolved after treatment...

...J. Harenberg; D. Schneider; L. Heilmann; H. Wolf Prophylaxis of thromboembolism with low molecular mass (LMM) heparin may offer several advantages over conventional heparin during pregnancy. Heparin-related side effects as osteoporosis, local allergy, thrombocytopenia and increase in liver enzymes...

...Richard H. White; Martha M. Daschbach; John P. McGahan; Kevin Keck; Gibbe H. Parsons; Ross P. Hartling; Dennis Mungall In a prospective, randomized clinical trial we compared the efficacy of subcutaneously (SC) administered (every 8 h) calcium heparin to intravenous (IV) sodium heparin...

... of the rapid activation phase is comparable to that of the control group, clot formation does not occur during the 10-min incubation period. Heparin (1 IU/ml) acts as an antagonist not only of the venom-induced FPA generation, but also of the PF 4 release. Prostaglandin E 1 (PGE 1 (150 ng/ml) does not inhibit...

...Patrizia Noris; Giampiera Bertolino; Mario Previtali; Maurizio Ferrario; Carlo L. Balduini We investigated ex vivo spontaneous platelet aggregation (SPA) in platelet-rich plasma in 37 patients with acute myocardial infarction. It occurred in about 50% of subjects receiving heparin after...

...W.A. Schumacher; C.L. Heran; S. Youssef; J.R. Megill; I. Michel; S.K. Durham The antithrombotic activities of aspirin, the thromboxane (Tx) A 2 /prostaglandin endoperoxide-receptor (TP-receptor) antagonist, SQ 30,741, and heparin were determined in anesthetized rats. Heparin (3 doses of 50, 300 U...

... and clotting. The times from onset of rotation until aggregation (T a ) and until coagulation (T c ) of the PRP samples are recorded. PITT was very sensitive and detected low concentrations of unfractionated heparin (0.01 IU/ml) in vitro. PITT parameters were significantly prolonged ex vivo 2 h after oral...

...R.J. Wagenvoord; H.H. Hendrix; H.J. Kolde; H.C. Hemker A new sensitive chromogenic heparin assay is developed, which is well suited for clinical use. For the assay two reaction mixtures are required which can be lyophilized and reconstituted on the day of use. These reagents are stable during...

... protein C (APC) was greater than that by heparin. In this study, we compared the bleeding complication of intravenously administered APC and heparin in rabbits, and also estimated primary hemostasis. When both anticoagulants were intravenously infused, the bleeding time from a punctured ear vein...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Anticoagulation Heparin Prothrombin time Thromboplastin HæmosfaKiM Original Paper Haemostasis 1996;26:11-15 G. Bade T. Fiers G. Leroux-Roels Coagulation Laboratory...

... with different doses of heparins of various molecular masses: unfractionated heparin (UH, 13 kDa), low-molecular-mass heparin (LMM-H, 5kD) and oligo-heparin (OL-H, 2 kD). The AXa activity levels of plasma samples were measured by an amidolytic method and expressed in AXa U/ ml. The antithrombotic effect...

...M. Monreal; E. Lafoz; A. Urrutia; J. Roncales; R. Galimany; C. Biosca; A. Corominas Beside the anticoagulant and antithrombotic activity, heparin also exerts a lipolytic activity. In a prospective study on patients with venous thromboembolism and some contraindications to coumarin therapy, a low...

..., instructions or products referred to in the content or advertisements. Thrombin Arterial thrombosis Hirudin Heparin r-Hirudin Hirulog Haemostasis 1994;24:69-80 Lina Badimona Beat J. Meyer1 Juan J. Badimonb Thrombin in Arterial Thrombosis Cardiovascular Research Center and Foundation CID (CSIC...

... treatment Heparin LMWH Haemostasis 1994;24:86-104 w.Kakkar Thrombosis Research Institute, Manresa Road. London SW3 6LR. England Venous Thrombosis Today Key Words Deep vein thrombosis prophylaxis diagnosis treatment Heparin LMWH Abstract Over the last 25 years, considerable progress has been made...

...Job Harenberg; Peter Roebruck; Dieter L. Heene In a multicenter, double-blind clinical trial in 1,968 inpatients 1 daily subcutaneous administration of LMW heparin plus 2 placebo injections or 3 × 5,000 IU unfractionated (UF) heparin was given for 10 (8-11) days. The primary end point...

...J.W.M. Krulder; A.F. Strebus; A.E. Meinders; E. Briët The aim of the study was to determine the effect of the antithrombin concentration on the anticoagulant response to heparin in vitro. Pooled plasma was depleted of antithrombin using heparin Sepharose. Unfractionated heparin (final concentration...

...S. Haas Prophylaxis with low-dose heparin has contributed significantly to the reduction in thromboembolic complications in surgery. Without prophylaxis, the rate of deep-vein thrombosis is about 30% in patients undergoing general surgery, rising up to 70% in orthopedic and trauma surgery...

...T.P. Baglin Unfractionated heparin is the commonest treatment for established venous thromboembolism. While this treatment undoubtedly reduces mortality and morbidity there are problems associated with its use. It does not always prevent thrombus propagation or embolisation, the low bioavailability...

...Giancarlo Agnelli Unfractionated heparin is a heterogeneous mixture of sulphated polysaccharides. The anticoagulant activity of unfractionated heparin is mainly accounted for by its fractions with a sequence with binding affinity for antithrombin III. The interaction of heparin with antithrombin...

... is key in the pathogenesis of thrombosis, recent studies have focussed on thrombin inhibition in the management of acute ischaemia. Heparin is the most widely used anticoagulant for acute management of thrombosis and is the treatment of choice in the prevention and treatment of venous thrombo-embolism...