...P. Drakos; B. Uziely; A. Nagler; S. Gillis; A. Eldor A case of heparin-induced thrombocytopenia and skin necrosis induced by coumarin is reported in a 58-year-old female patient suffering from metastatic breast adenocarcinoma and deep vein thrombosis. The thrombosis resolved after treatment...

... and clotting. The times from onset of rotation until aggregation (T a ) and until coagulation (T c ) of the PRP samples are recorded. PITT was very sensitive and detected low concentrations of unfractionated heparin (0.01 IU/ml) in vitro. PITT parameters were significantly prolonged ex vivo 2 h after oral...

...), and soluble fibrin monomers (SF), preoperatively, and on days 1, 7 and 35 in plasma of patients undergoing total hip arthroplasty. The study was part of a mul-ticentre study in which the patients were randomized to receive a subcutanous injection of low molecular weight heparin (LMWH, dalteparin, Fragmin®...

... in the affected cerebral hemisphere. Heparin also decreased the mortality to 30% at a dose of 600 U/kg/h, but marked bleeding was observed at the incised wound. These findings suggest that argatroban is a more effective and safer anticoagulant than heparin for the prevention of ischemic damage on cerebral...

...J. Storck; N. Höllger; R.E. Zimmermann We present results concerning the pathogenic mechanism of heparin-induced thrombocytopenia type I. An ELISA was developed for directly measuring the expression of glycoprotein IIb/IIIa (GPIIb/IIIa) on platelets in the presence and absence of ADP and under...

... associated to a different incidence of heparin-related bleeding complications, we report our experience with 1,103 consecutive patients with venous thromboembolism (VTE) receiving full-dose heparin therapy. Six points of clinical and laboratory information were recorded on admission and then compared...

...R.J. Wagenvoord; H.H. Hendrix; H.J. Kolde; H.C. Hemker A new sensitive chromogenic heparin assay is developed, which is well suited for clinical use. For the assay two reaction mixtures are required which can be lyophilized and reconstituted on the day of use. These reagents are stable during...

... protein C (APC) was greater than that by heparin. In this study, we compared the bleeding complication of intravenously administered APC and heparin in rabbits, and also estimated primary hemostasis. When both anticoagulants were intravenously infused, the bleeding time from a punctured ear vein...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Anticoagulation Heparin Prothrombin time Thromboplastin HæmosfaKiM Original Paper Haemostasis 1996;26:11-15 G. Bade T. Fiers G. Leroux-Roels Coagulation Laboratory...

... with different doses of heparins of various molecular masses: unfractionated heparin (UH, 13 kDa), low-molecular-mass heparin (LMM-H, 5kD) and oligo-heparin (OL-H, 2 kD). The AXa activity levels of plasma samples were measured by an amidolytic method and expressed in AXa U/ ml. The antithrombotic effect...

...M. Monreal; E. Lafoz; A. Urrutia; J. Roncales; R. Galimany; C. Biosca; A. Corominas Beside the anticoagulant and antithrombotic activity, heparin also exerts a lipolytic activity. In a prospective study on patients with venous thromboembolism and some contraindications to coumarin therapy, a low...

..., instructions or products referred to in the content or advertisements. Thrombin Arterial thrombosis Hirudin Heparin r-Hirudin Hirulog Haemostasis 1994;24:69-80 Lina Badimona Beat J. Meyer1 Juan J. Badimonb Thrombin in Arterial Thrombosis Cardiovascular Research Center and Foundation CID (CSIC...

... treatment Heparin LMWH Haemostasis 1994;24:86-104 w.Kakkar Thrombosis Research Institute, Manresa Road. London SW3 6LR. England Venous Thrombosis Today Key Words Deep vein thrombosis prophylaxis diagnosis treatment Heparin LMWH Abstract Over the last 25 years, considerable progress has been made...

...Job Harenberg; Peter Roebruck; Dieter L. Heene In a multicenter, double-blind clinical trial in 1,968 inpatients 1 daily subcutaneous administration of LMW heparin plus 2 placebo injections or 3 × 5,000 IU unfractionated (UF) heparin was given for 10 (8-11) days. The primary end point...

...Richard H. White; Martha M. Daschbach; John P. McGahan; Kevin Keck; Gibbe H. Parsons; Ross P. Hartling; Dennis Mungall In a prospective, randomized clinical trial we compared the efficacy of subcutaneously (SC) administered (every 8 h) calcium heparin to intravenous (IV) sodium heparin...

... of the rapid activation phase is comparable to that of the control group, clot formation does not occur during the 10-min incubation period. Heparin (1 IU/ml) acts as an antagonist not only of the venom-induced FPA generation, but also of the PF 4 release. Prostaglandin E 1 (PGE 1 (150 ng/ml) does not inhibit...

...Patrizia Noris; Giampiera Bertolino; Mario Previtali; Maurizio Ferrario; Carlo L. Balduini We investigated ex vivo spontaneous platelet aggregation (SPA) in platelet-rich plasma in 37 patients with acute myocardial infarction. It occurred in about 50% of subjects receiving heparin after...

...W.A. Schumacher; C.L. Heran; S. Youssef; J.R. Megill; I. Michel; S.K. Durham The antithrombotic activities of aspirin, the thromboxane (Tx) A 2 /prostaglandin endoperoxide-receptor (TP-receptor) antagonist, SQ 30,741, and heparin were determined in anesthetized rats. Heparin (3 doses of 50, 300 U...

...J. Harenberg; D. Schneider; L. Heilmann; H. Wolf Prophylaxis of thromboembolism with low molecular mass (LMM) heparin may offer several advantages over conventional heparin during pregnancy. Heparin-related side effects as osteoporosis, local allergy, thrombocytopenia and increase in liver enzymes...

...M. Monreal; G. Galego; L. Monreal; A.M. Angles; J. Monasterio; B. Oller In a random, blind study, we compared the antithrombotic potential of unfractioned heparin, a low-molecular weight heparin (LMWH) and a recombinant hirudin (r-hirudin) given subcutaneously in a jugular vein thrombosis model...