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Keywords: Factor Xa
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Journal Articles
Pathophysiology of Haemostasis and Thrombosis (1992) 22 (2): 58–65.
Published Online: 28 April 2009
... catalyses the inactivation of factor Xa and thrombin. Compared to heparin and most low-molecular-weight heparins, Orgaran has a much higher anti-Xa/anti-IIa ratio. The inactivation of factor Xa is mediated by AT III and that of thrombin by both AT III and heparin cofactor II. Compared to heparin, which...
Journal Articles
Pathophysiology of Haemostasis and Thrombosis (1992) 22 (2): 66–72.
Published Online: 28 April 2009
... Affinity to Antithrombin III (Org 10849) KeyWords Orgaran ORG 10172 Heparin Factor Xa Factor IXa Thrombin Prothrombinase Antithrombin III Abstract Orgaran (Org 10172), which has antithrombotic activity in man with apparently minimal bleeding side effects, is a mixture of low-molecularweight heparan...
Journal Articles
Journal Articles
Pathophysiology of Haemostasis and Thrombosis (1990) 20 (2): 81–92.
Published Online: 24 April 2009
... is evident, there seems to be no direct correlation between amount and duration of factor IIa or factor Xa inhibition and extent and duration of the inhibition of thrombus formation. 19 12 1988 10 07 1989 24 4 2009 Heparin Glycosaminoglycans Thrombosis Pentosanpolysulfate...
Journal Articles
Pathophysiology of Haemostasis and Thrombosis (1990) 20 (3): 125–135.
Published Online: 24 April 2009
... by factor Xa and calcium in the presence and absence of exogenous factor Va. Using a chromogenic substrate assay to assess thrombin formation, we observed that all the above cell lines accelerated prothrombin activation in the absence of exogenous factor Va. The order of effectiveness was COLO 205...
Journal Articles
Pathophysiology of Haemostasis and Thrombosis (1989) 19 (1): 13–20.
Published Online: 24 April 2009
... to analyze the interrelationship between the coagulation methods: Heptest, activated partial thromboplastin time, thrombin clotting time, and S 2222 chromogenic anti-factor Xa test. The results showed a high correlation between Heptest and S 2222 anti-factor Xa method for unfractionated and LMW heparin (r...
Journal Articles
Pathophysiology of Haemostasis and Thrombosis (1986) 16 (2): 106–115.
Published Online: 21 April 2009
...H. Vinazzer; M. Woler The depolymerized heparin fragment PK 10169 was compared with unfractioned mucosal sodium heparin. The inhibition of factors Xa and IXa by heparin and by PK 10169 was comparable on a weight base, whilst the inhibition of thrombin by PK 10169 was at least 5 times weaker than...
Journal Articles
Pathophysiology of Haemostasis and Thrombosis (1981) 10 (6): 315–347.
Published Online: 17 April 2009
... Words. Thrombin Factor VIIa - Factor IXa Factor Xa Inhibition Organic compounds Abstract. A series of 53 organic chemicals belonging to the groups of organic phos­ phates, sulfonyl derivatives and carbamates were screened for their activity against the coagulation factors IIa (thrombin), VIIa...
Journal Articles
Pathophysiology of Haemostasis and Thrombosis (1978) 7 (6): 352–358.
Published Online: 16 April 2009
...H. Vinazzer A simple assay method for platelet factor 4 is described. When factor Xa was added to a system containing antithrombin III in excess and heparin in low concentration, the amount of factor Xa immediately inactivated was found to be a function of the concentration of heparin. When...
Journal Articles
Pathophysiology of Haemostasis and Thrombosis (1977) 6 (5): 283–293.
Published Online: 16 April 2009
...H. Vinazzer A photometric assay procedure for platelet factor 4 is described. The synthetic oligopeptide benzoyl-Ile-Glu-Gly-Arg- p -nitroanilide (S-2222) is used as a substrate. By the action of factor Xa, p -nitroaniIine (pNA) is split form the peptide bond. The amount of pNA liberated from S...
Journal Articles
Pathophysiology of Haemostasis and Thrombosis (1978) 7 (2-3): 121–126.
Published Online: 16 April 2009
... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Chromogenic substrates Amidolytic methods Antithrombin III Thrombin Factor Xa Haemostasis 7: 121-126 (1978) On Use of Chromogenic Substrates for Studies of Coagulation Inhibitors...
Journal Articles
Pathophysiology of Haemostasis and Thrombosis (1978) 7 (2-3): 92–94.
Published Online: 16 April 2009
... for Factor Xa L eif Aurell, Roger Simomson, Salo Arielly, Gunilla Karlsson, Petter Friberger and Göran Claeson AB Kabi, Peptide Research, Mölndal Key Words. Chromogenic substrate Factor Xa- Trypsin S-2222 Abstract. The factor-Xa-sensitive substrate Bz-Ile-Glu-Gly-Arg-p-nitroanilide has been made more...
Journal Articles
Pathophysiology of Haemostasis and Thrombosis (1978) 7 (2-3): 170–176.
Published Online: 16 April 2009
... the specificity pocket. It is demonstrated that inhibitors with marked specificity for a single enzyme can be produced, and with the help of such selective compounds it is shown that inhibition of factor Xa is more significant for overall anticoagulant effect than inhibition of thrombin. 16 4 2009 ©...
Journal Articles
Pathophysiology of Haemostasis and Thrombosis (2001) 31 (3-6): 234–240.
Published Online: 25 March 2002
... coagulation factor Xa. It shows ∼70% homology and possesses the characteristic Gla domain, two EGF domains and serine proteinase domain. To examine structure-function relationships, we generated a molecular model of trocarin based on a human factor Xa des-Gla crystal structure (1xka) as template. Based...
Journal Articles
Pathophysiology of Haemostasis and Thrombosis (2001) 31 (3-6): 279–287.
Published Online: 25 March 2002
.... Anticoagulant Secreted phospholipase A 2 Snake venom Mammalian Factor Xa Factor Va Anticoagulant Proteins and Diagnostic Agents Haemostasis 2001;31:279 287 Anticoagulant Venom and Mammalian Secreted Phospholipases A2: Protein- versus Phospholipid-Dependent Mechanism of Action Carine M. Mouniera Cassian...
Journal Articles