...Egon Persson Des(1-38)- and des(1-44)-factor Vila (fVIIa) were inhibited with Phe-Phe-Arg-chloromethyl ketone (FFR-cmk). Des(1-38)-FFR-fVIIa inhibited tissue factor (TF)-enhanced fVIIa amidolytic activity with an IC 50 value of 15 n M , whereas 3-and 6-fold higher values were obtained with des(1-44...

...James H. Morrissey Factor VIla (FVIIa) is the triggering enzyme of the blood clotting cascade in hemostasis and thrombosis and may play an important role in hypercoagulable states. Indeed, certain epidemiologic studies have found elevated FVII coagulant activity to be an independent risk factor...

...Kenneth A. Bauer; Sabine Eichinger; Pier M. Mannucci; Robert D. Rosenberg To evaluate the mechanism responsible for the generation of factor VIla in vivo, we measured the levels of this enzyme after administering purified factor IX concentrates to patients with hemophilia B. Their factor VIla...

... inhibitors have complicated the clinical picture, and in whom a surgical procedure was indicated. As part of a compassionate use program devised by the producer of this genetically engineered factor VIla, 12 patients underwent life-saving or essential surgery where the recombinant factor VIla product...

...Fletcher B. Taylor, Jr. Anti-tissue factor antibody and active site-inhibited factor VIla inhibit both the disseminated intravascular coagulant response to LD 100 Escherichia coli and its lethal inflammatory effects. In contrast, active site inhibited factor Xa while completely inhibiting...

...Kenneth A. Bauer Factor VII deficiency is a relatively infrequent hereditary bleeding disorder. Recombinant factor VIla has been used to treat patients with factor VII deficiency with bleeding episodes or undergoing surgery. The drug has shown a high efficacy rate and will provide factor VH...

...W.A. Deijk; M.C.E. van Dam-Mieras; A.D. Muller A preliminary report suggests a correlation between metastatic prostate cancer and increased plasma factor Vila levels. Prostate cancer without metastases and prostate hypertrophy showed no clear pattern in factor VIla. Further investigations...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Factor VII Factor Vila Cold activation factor VII Blood transfusion Blood bank procedures Haemostasis 13: 186-191...