...A.L. Bloom Management of patients with factor VIII (and IX) inhibitors includes management of acute bleeds and methods to induce immune suppression and tolerance and to detect patients at risk of developing inhibitors. The methods used over the years to treat acute bleeding have been more or less...

...Dennis A. Noe It appears that the binding of coagulation factor VIII to von Willebrand factor in plasma stabilizes the otherwise highly labile factor VIII. A mathematical model of factor VIII kinetics has been developed based upon this proposed effect of factor VIII binding. The model’s kinetic...

... from any ideas, methods, instructions or products referred to in the content or advertisements. Hemophiliacs Arthropathy Factor VIII ‘On demand’ prophylaxis Haemostasis 1992;22:245-246 Louis M. Aledort Mount Sinai Medical Center, New York, N.Y., USA Arthropathy and Substitution Therapy Key...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Plasma products Coagulation factor concentrates Factor VIII Factor IX...

...W.M. Smid; J. van der Meer; M.R. Halie The efficacy and safety of a monoclonal purified factor VIII concentrate (Hemofil M) were assessed in a historically controlled study in 22 HIV-negative patients with haemophilia A, previously treated with various concentrates. Data from 5 years of follow-up...

...Stefan Neuenschwander; Vladimir Pliška The sheep haemophilia A, recently described in a flock of White Alpine sheep, is probably caused by the production of a less potent mutant of factor VIII (F-VIII). Other potential mechanisms, such as drastic reduction (or lack) of F-VIII production...

... substrates, hirudin may serve to discriminate between actions mediated by thrombin, its precursors, cofactors and effectors and actions of other enzyme systems. The principle of this hirudin application is exemplified for factor-V- and factor-VIII-dependent anticoagulant activity of protein C. 24 4...

...N.J. Dawson; G. Kemball-Cook; T.W. Barrowcliffe We have assayed two different monoclonal-antibody-purified concentrates (A and B) and one conventional concentrate (C), against the 3rd International Standard for factor VIII concentrate, using one-stage, two-stage and chromogenic methods. One-stage...

...R.J. Wagenvoord; H.H. Hendrix; H.C. Hemker The aim of this study was the development of a simple chromogenic factor VIII assay for practical clinical use. The criteria that the assay fulfils are: (1) The method is so sensitive that even 1 % factor VIII in human plasma is easily detected. (2...

...Jolyon Jesty A simple numerical model of the activation of factor X by factors IXa and VIII has been constructed in order to identify and examine the major controls that operate in a nonflowing system in the presence of (1) inhibitors of factor Xa and (2) feedback activation of factor VIII...

...C. Rothschild; J. Amiral; M. Adam; D. Meyer Standardized factor VIII (FVIII)-defιcient plasma is necessary for the clotting assay of this protein. Ethical considerations and prevalence of HIV seropositivity in hemophilia A patients have required the replacement of severe hemophilia A plasma...

...Akiko Adachihara Huang-lien-chieh-tu-tang (HLCT) extract was given orally to a patient with severe hemophilia A. The plasma concentration of factor VIII rose from less than 1 to 41 % 1 h after oral administration of HLCT extract. APTT also decreased from 102.0 to 70.9 s. In vitro experiments, HLCT...

...J. de Jonge; C.T. Smit Sibinga; P.C. Das As a by-product of a new high-yield method of production of freeze-dried factor VIII, red cell concentrate (RCC) containing a small amount of heparin besides CPDA-1 was studied. Compared to CPDA-1-stored RCC no difference was found in hematology parameters...

... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Blood groups Oral contraceptives Factor VIII Secretor character Sex Smoking...

.... Prothrombin activation Factor X activation Phospholipids Factor V Factor VIII Haemostasis 16: 216-226 (1986) © 1986 S. Karger AG. Basel 0301-0147/86/0164-0216S2.75/0 Role of Accessory Components in the Activation of Vitamin K-Dependent Coagulation Factors J.L.M.L. van Rijn, R.F.A. Zwaal, H.C. Hemker, J...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Thrombin Heparin Factor V Factor VIII Platelets Haemostasis 16: 71-81 (1986) © 1986 S. Karger A G . Basel 0301...

...M.J. Seghatchian; G. Kemball-Cook; T.W. Barrowcliffe The absorption of factor VIII from gel filtration fractions, concentrates and plasma by aluminium hydroxide has been studied. Significant quantities of factor VIII could be removed when the protein concentration was low; the percentage absorbed...

...F. Madaras; W.R. Bell; P.A. Castaldi A simple procedure has been developed for the isolation of coagulation factor VIII (F VIII) from plasma in a form which induces a monospecific antibody in rabbits. Amino acid precipitation from plasma was followed by gel filtration on Sepharose 4B and further...

...B. Boneu; D. Durand; F. Counillon; J.P. Charlet; R. Bierme; J.M. Suc Factor VIII complex was studied in patients presenting arterial hypertension. Visceral involvement was quantified using a clinical index calculated from ocular fundus, renal function and left ventricular hypertrophy data...

...G.E. Elder; E.E. Mayne; J.G. Daly; A.L. Kennedy; D.R. Hadden; D.A.D. Montgomery; J.A. Weaver Antithrombin III, factor VIII, fibrinogen and fribrinolytic activity were measured in two groups of long-standing insulin-dependent diabetic subjects (24 with proliferative retinopathy, 24 without...