...M.M. Samama; D. Simon; M.H. Horellou; M. Trossaërt; I. Elalamy; J. Conard The diagnostic strategies and clinical characteristics of thrombophilia associated with heterozygous or homozygous factor V Leiden mutation have been determined according to the literature and to a personal study in 51...

...David Green; Kochurani Maliekel; Elena Sushko; Rasheed Akhtar; Gerald A. Soff Background : Resistance to activated protein C (aPC) is usually linked to factor V Leiden, but may occur in other disorders associated with hypercoagulability. In this study, we investigated the frequency of resistance...

...Juan-Antonio Iniesta; Javier Corral; Jacinto Fernández-Pardo; Rocío González-Conejero; Vicente Vicente Factor V Leiden is already well established to be involved in venous thrombosis but not in coronary heart disease. Results are conflicting and even antagonistic in cerebrovascular disease (CVD...

... method (APCM) which utilized factor V-depleted plasma, for the detection of the factor V Leiden mutation. A total of 110 patients were included in this study. This included 32 patients on coumadin therapy, 7 patients on heparin therapy, 5 patients on both anticoagulants therapy, and 24 patients who were...

...Joaquín Sánchez; José Román; Maria J. de la Torre; Francisco Velasco; Antonio Torres The aim of the study is to determine if a novel thrombophilia mechanism (factor V Leiden) that is associated with resistance to activated protein C (APC) is in itself a risk factor for the development of ischemic...

... are small, and results are varied by geography, tumor type, stage of disease and therapy. Nevertheless, it seems that factor V Leiden and prothrombin mutation may increase VTE risk in cancer patients. Data also exist for hyperhomocysteinemia. Cancer patients with thrombophilia who have a central vein...

...Lisa F. Lincz; Amy Lonergan; Fiona E. Scorgie; Phillip Rowlings; Richard Gibson; Andrew Lawrie; Michael Seldon Measurement of endogenous thrombin potential (ETP) detects hypercoagulability and can be used to identify activated protein C resistance due to factor V Leiden (FVL). However, not all...

...F.R. Rosendaal The key to understanding why certain individuals develop deep vein thrombosis at varying times, despite similar risk factors being present, is the realization of the importance of gene–gene and gene–environment interactions between risk factors. The discovery of factor V Leiden...

...Gregorios A. Paspatis; Aikaterini Sfyridaki; Nikolaos Papanikolaou; Kostantinos Triantafyllou; Aikaterini Livadiotaki; Andreas Kapsoritakis; Niki Lydataki Objective: The aim of our study was to determine the frequency of resistance to activated protein C (APC), factor V Leiden (FVL...

... factor V Leiden mutation and vascular thombosis following liver transplantation. Liver Transpl Surg 1998;4:58–61. 11. Delorme MA, Adams PC, Grant D, Ghent C, Walker IR, Wall WJ: Orthotopic liver transplantation in a patient with combined hemophilia A and B. Am J Hematol 1990;33:136–138. 12...

...F. Araújo; A. Santos; V. Araújo; I. Henriques; F. Monteiro; E. Meireles; I. Moreira; D. David; M.J. Maciel; L.M. Cunha-Ribeiro Objective: We investigate whether each of the following: HPA-1, Factor V Leiden, prothrombin gene variant and the methylene tetrahydrofolate reductase gene (MTHFR) mutation...

... thrombosis. The aim of the study was to investigate the prevalence of APCR associated with factor V Leiden mutation and its relevance in comparison to other risk factors for thromboembolic disorders in women with a history of previous complicated pregnancies (history of fetal loss in the second and third...

..., instructions or products referred to in the content or advertisements. Hereditary thrombophilia Familial thrombosis Venous thrombosis Factor V Leiden Factor II mutation Antithrombin deficiency Protein C deficiency Protein S deficiency Haemostasis 1999;29:76 99 Clinical Aspects and Laboratory...

... participants of the Rotterdam Study, a population-based cohort study among subjects aged 55 years or over, and from participants of the Rotterdam Stroke Databank, a hospital-based stroke registry, to evaluate the association of the factor V Leiden mutation and activated protein C (APC) response with dementia...

.... Factor V Leiden Factor V Activated protein C Prothrombin fragment 1+2 Activated protein C resistance Original Paper Haemostasis 1998;28:31 36 Received: March 25, 1998 Accepted in revised form: July 8, 1998 Circulating Activated Protein C in Subjects with Heterozygous Gln506-Factor V Jari Petäjäa c...